A5113140216- Lung Cancer Treatments and Mutations
- Plant tissue culture and regeneration
- Seaweed-derived Bioactive Compounds
- Lung Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Acute Lymphoblastic Leukemia research
- GABA and Rice Research
- PI3K/AKT/mTOR signaling in cancer
- Genomics and Phylogenetic Studies
- Biomedical Research and Pathophysiology
- Gastrointestinal Tumor Research and Treatment
- Chronic Kidney Disease and Diabetes
- Tissue Engineering and Regenerative Medicine
- Plant biochemistry and biosynthesis
- Medical Image Segmentation Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Phytochemical compounds biological activities
- Lymphoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Effects of Radiation Exposure
Icahn School of Medicine at Mount Sinai
2025
Shenyang Pharmaceutical University
2022-2024
Weifang Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Second Hospital of Shandong University
2024
Roche (Switzerland)
2017-2018
Shandong Agricultural University
2016
BackgroundThe phase III ALEX study in patients with treatment-naive advanced anaplastic lymphoma kinase mutation-positive (ALK+) non-small-cell lung cancer (NSCLC) met its primary end point of improved progression-free survival (PFS) alectinib versus crizotinib. Here, we present detailed central nervous system (CNS) efficacy data from ALEX.Patients and methodsOverall, 303 aged ≥18 years underwent 1:1 randomization to receive twice-daily doses 600 mg or crizotinib 250 mg. Brain imaging was...
PEGylation has been widely used to improve the pharmacokinetic properties of prodrug self-assembled nanoparticles (prodrug-SANPs). However, impacts amount PEG on self-assemble stability, cellular uptake, pharmacokinetics, and antitumor efficacy prodrug-SANPs are still unknown. Herein, selenoether bond bridged docetaxel dimeric was synthesized as model prodrug. Five were designed by using different mass ratios prodrugs (Wprodrug/WDSPE-mPEG2000 = 10:0, 9:1, 8:2, 7:3 6:4), defined Pure drug...
Abstract Purpose: To investigate the relationship between spatial parotid dose and risk of xerostomia in patients undergoing head-and-neck cancer radiotherapy, using machine learning (ML) methods.
Methods: Prior to conducting voxel-based ML analysis dose, two steps were taken: 1) The was standardized through deformable image registration a reference patient; 2) Bilateral doses regrouped into contralateral ipsilateral portions depending on their proximity gross tumor target....
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, hyperlipidemia one major inducing factor CVD. It worthy to note that fucoidans are reported have hypolipidemic activity with species specificity; however, underlying mechanisms action far from clarification. This study aimed at investigating plasma lipid‐lowering fucoidan L. japonica Aresch by detecting levels hepatic genes involved in lipid metabolism. Our results demonstrated F3 significantly lowered...
Toona sinensis Roem is a popular leafy vegetable in Chinese cuisine and also used as traditional medicine. In this study, leaf samples were collected from the same plant on two development stages then for high-throughput Illumina RNA-sequencing (RNA-Seq). 125,884 transcripts 54,628 unigenes obtained through de novo assembly. A total of 25,570 could be annotated with known biological functions, which indicated that T. leaves shoots undergoing multiple developmental processes especially active...
This study is to evaluate the impact of different normal lung volumes on radiation pneumonitis (RP) prediction in patients with locally advanced non-small-cell-lung-cancer (LA-NSCLC) receiving radiotherapy. Three dosimetric variables (V20, V5, and mean dose (MLD)) were calculated using treatment plans from 442 LA-NSCLC enrolled NRG Oncology RTOG 0617. defined based plan: total excluding gross-tumor-target (TL-GTV), clinical-target-volume (TL-CTV), planning-target-volume (TL-PTV). Binary...