A5011571368- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Adaptive optics and wavefront sensing
- Tryptophan and brain disorders
- Stellar, planetary, and galactic studies
- Astronomy and Astrophysical Research
- GNSS positioning and interference
- Photoreceptor and optogenetics research
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
- Infant Health and Development
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Anesthesia and Pain Management
- Adipose Tissue and Metabolism
University of Florida
2012-2025
Eastside Technical Center
2014
Opioids are commonly used for pain relief clinically and reduce hyperalgesia in most animal models. Two injections of acidic saline into one gastrocnemius muscle 5 days apart produce a long-lasting bilateral without associated tissue damage. The current study was undertaken to assess the effects opioid agonists on mechanical induced by repeated intramuscular acid. Morphine (μ-agonist), [d-Ala<sup>2</sup>,<i>N</i>-Me-Phe<sup>4</sup>,Gly-ol<sup>5</sup>]-enkephalin (μ-agonist; DAMGO),...
The hypothalamic paraventricular nucleus (PVN) controls neuroendocrine axes and the autonomic nervous system to mount responses that cope with energetic burdens of psychological or physiological stress. Neurons in PVN express angiotensin Type 1a receptor (PVN Agtr1a ) are implicated stress responses; however, mechanism by which these neurons coordinate activation sympathetic outflow remains unknown. Here, we use a multidisciplinary approach investigate intra-PVN signaling mechanisms couple...
The Mid-resolution InfRAreD Astronomical Spectrograph (MIRADAS, a near-infrared multi-object echelle spectrograph operating at spectral resolution R=20,000 over the 1-2.5μm bandpass) was selected in 2010 by Gran Telescopio Canarias (GTC) partnership as next-generation for world's largest optical/infrared telescope, and is being developed an international consortium. MIRADAS consortium includes University of Florida, Universidad de Barcelona, Complutense Madrid, Instituto Astrofísica...
The Mid-resolution InfRAreD Astronomical Spectrograph (MIRADAS, a near-infrared multi-object echelle spectrograph operating at spectral resolution R=20,000 over the 1-2.5μm bandpass) was selected by Gran Telescopio Canarias (GTC) partnership as next-generation for world's largest optical/infrared telescope, and is being developed an international consortium. MIRADAS consortium includes University of Florida, Universidad de Barcelona, Complutense Madrid, Instituto Astrofísica Canarias,...
We describe the design, development, and laboratory test results of cryogenic probe arms feeding deployable integral field units (IFUs) for Mid-resolution InfRAreD Astronomical Spectrograph (MIRADAS) - a near-infrared multi-object echelle spectrograph 10.4-meter Gran Telescopio Canarias. MIRADAS selects targets using 20 positionable pickoff mirror optics on arms, each 3.7x1.2-arcsec view to units, while maintaining excellent diffraction-limited image quality. The are based concept developed...
According to the World Health Organization, cardiovascular disease (CVD) continues be leading cause of death worldwide. While a myriad genetic and environmental factors influence development CVD, there are several lines evidence suggesting that psychological stress contributes health disparities in CVD observed amongst different populations. Our lab seeks understand effects psychosocial on using model chronic social defeat (CSDS) mice. In this paradigm, male C57BL/6 mice undergo brief daily...
The clock protein PERIOD1 (PER1) is known to regulate the transcription of many genes, impacting subsequent physiological responses and working with other proteins establish rhythmicity in processes such as blood pressure regulation. Global PER1 knock-out (KO) male rats associated increased severity salt-sensitive (SS) hypertensive phenotype Dahl SS rats. Male KO demonstrated reduced amplitude heart rate well altered renal electrolyte fluid balance accompanying changes expression relevant...
Brain and muscle ARNT-Like 1 (BMAL1) is a circadian clock transcription factor that regulates physiological functions. Male adrenal-specific Bmal1 ( AS Cre/+ ::Bmal1) KO mice displayed blunted serum corticosterone rhythms, altered blood pressure rhythm, timing of eating, but there lack knowledge in females. This study investigates the role adrenal BMAL1 renal electrolyte handling urinary aldosterone levels response to low salt male female mice. Mice were placed metabolic cages measure...
Social adversity is a major contributor to chronic illnesses such as hypertension, obesity, and type-2 diabetes. Populations associated with lower social status are disproportionately affected by illnesses, possibly due recurrent exposure stress adversity. Previous studies from our group others have revealed that Chronic Defeat Stress (CSDS) in mice, which models the effects of low status, results anxiety-like behavior, endocrine abnormalities cardiovascular perturbations. In this paradigm,...
The worldwide prevalence of hypertension continues to rise, shortening lifespan and contributing the risk cardiovascular disease stroke. Although there are numerous factors, social adversity is believed be one that may account, in part, for disparities rates treatment outcomes. We have recently begun evaluate whether chronic defeat stress (CSDS) can effectively model aspects stress-induced disease. Adult male C57BL/6J mice were implanted with telemetry devices recorded blood pressure, heart...
Interoception broadly refers to awareness of one's internal milieu. Vagal sensory afferents monitor the milieu and maintain homeostasis by engaging brain circuits that alter physiology behavior. While importance body-to-brain communication underlies interoception is implicit, vagal corresponding shape perception viscera are largely unknown. Here, we use mice parse neural subserving heart gut. We determine expressing oxytocin receptor, hereafter referred as NDGOxtr, send projections aortic...
MIRADAS (Mid-resolution InfRAreD Astronomical Spectrograph) is the facility near-infrared multi-object echelle spectrograph for Gran Telescopio Canarias (GTC) 10.4-meter telescope. operates at spectral resolution R=20,000 over 1-2.5µm bandpass), and provides multiplexing (up to N=12 targets) spectro-polarimetry. The consortium includes University of Florida, Universidad de Barcelona, Complutense Madrid, Instituto Astrofísica Canarias, Institut d'Estudis Espacials Catalunya Nacional Autonoma...
Blood pressure (BP) is under constant control and regulation by an extensive neural network that spans a number of brain regions. This includes the median preoptic nucleus (MnPO) which directly projects to pre-autonomic neurons hypothalamus increase BP. While angiotensin type-1 receptors (AT 1 R) are expressed in MnPO project BP, role type-2 2 not clear. Here, we combine use AT R-Cre mice, neuroanatomical techniques, vivo optogenetics, pharmacology, cardiovascular physiology test hypothesis...