A5103249932- Neutrino Physics Research
- Radiation Detection and Scintillator Technologies
- Genetic Associations and Epidemiology
- Particle physics theoretical and experimental studies
- Cancer Genomics and Diagnostics
- Dark Matter and Cosmic Phenomena
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Astrophysics and Cosmic Phenomena
- Atomic and Subatomic Physics Research
- Renal and related cancers
- Particle Detector Development and Performance
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Molecular spectroscopy and chirality
- Particle accelerators and beam dynamics
- Advanced Chemical Physics Studies
- Bioinformatics and Genomic Networks
- Magnetic confinement fusion research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Electron Spin Resonance Studies
- Molecular Spectroscopy and Structure
- Nuclear physics research studies
University of Sussex
2020-2025
Institute of Cancer Research
2023-2025
University College London
2024
Dana-Farber Cancer Institute
2024
Cancer Institute (WIA)
2024
Institute of Cancer Research
2023-2024
Campbell Collaboration
2023
Abstract For many cancers there are only a few well-established risk factors. Here, we use summary data from genome-wide association studies (GWAS) in Mendelian randomisation (MR) phenome-wide study (PheWAS) to identify potentially causal relationships for over 3,000 traits. Our outcome datasets comprise 378,142 cases across breast, prostate, colorectal, lung, endometrial, oesophageal, renal, and ovarian cancers, as well 485,715 controls. We complement this analysis by systematically mining...
Abstract Clear cell renal carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description its genomic landscape lacking. We report whole genome sequencing 778 ccRCC patients enrolled in 100,000 Genomes Project, providing for detailed somatic mutational ccRCC. identify candidate driver genes, which as well emphasising major role epigenetic regulation highlight additional biological pathways extending opportunities therapeutic interventions. Genomic characterisation...
The SNO+ Collaboration reports the first evidence of reactor antineutrinos in a Cherenkov detector. nearest nuclear reactors are located 240 km away Ontario, Canada. This analysis uses events with energies lower than any previous large water Two analytical methods used to distinguish from background 190 days data and yield consistent for combined significance 3.5σ.
The direction of individual <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mrow><a:mmultiscripts><a:mrow><a:mi mathvariant="normal">B</a:mi></a:mrow><a:mprescripts/><a:none/><a:mrow><a:mn>8</a:mn></a:mrow></a:mmultiscripts></a:mrow></a:math> solar neutrinos has been reconstructed using the <d:math xmlns:d="http://www.w3.org/1998/Math/MathML" display="inline"><d:mrow><d:mi>SNO</d:mi><d:mo>+</d:mo></d:mrow></d:math> liquid scintillator detector. Prompt, directional...
Abstract The SNO $$+$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mo>+</mml:mo> </mml:math> collaboration reports its first spectral analysis of long-baseline reactor antineutrino oscillation using 114 tonne-years data. Fitting the neutrino probability to observed energy spectrum yields constraints on mass-squared difference $$\Delta m^2_{21}$$ <mml:mrow> <mml:mi>Δ</mml:mi> <mml:msubsup> <mml:mi>m</mml:mi> <mml:mn>21</mml:mn> <mml:mn>2</mml:mn> </mml:msubsup> </mml:mrow>...
Abstract Although treatment options for B-cell malignancies have expanded, many patients continue to face limited response rates, highlighting an urgent need new therapeutic targets. To prioritize candidate drug targets malignancies, we employed Mendelian Randomization estimate potentially causal relationships between 445 immune cell traits and six cancers: follicular lymphoma (FL), diffuse large (DLBCL), Hodgkin (HL), marginal zone (MZL), chronic lymphocytic leukemia (CLL), multiple myeloma...
This paper reports results from a search for single and multi-nucleon disappearance the $^{16}$O nucleus in water within \snoplus{} detector using all of available data. These so-called "invisible" decays do not directly deposit energy but are instead detected through their subsequent nuclear de-excitation gamma-ray emission. New limits given partial lifetimes: $\tau(n\rightarrow inv) > 9.0\times10^{29}$ years, $\tau(p\rightarrow 9.6\times10^{29}$ $\tau(nn\rightarrow 1.5\times10^{28}$...
The $\mathrm{SNO}+$ experiment collected data as a low-threshold water Cherenkov detector from September 2017 to July 2019. Measurements of the 2.2-MeV $\ensuremath{\gamma}$'s produced by neutron capture on hydrogen were made using an Am-Be calibration source, for which large fraction emitted neutrons are simultaneously with 4.4-MeV $\ensuremath{\gamma}$. Analysis delayed coincidence between $\ensuremath{\gamma}$ and revealed detection efficiency that is centered around 50% varies at level...
SNO+ is a large-scale liquid scintillator experiment with the primary goal of searching for neutrinoless double beta decay, and located approximately 2 km underground in SNOLAB, Sudbury, Canada. The detector acquired data two years as pure water Cherenkov detector, starting May 2017. During this period, optical properties were measured situ using deployed light diffusing sphere, improving model energy response systematic uncertainties. parameters included attenuation coefficients, effective...
Abstract For many cancers there are few well-established risk factors. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide study (PheWAS) to identify causal relationships. We performed MR-PheWAS of breast, prostate, colorectal, lung, endometrial, oesophageal, renal, and ovarian cancers, comprising 378,142 cases 485,715 controls. To derive more comprehensive insight into disease aetiology we systematically mined the literature...
Abstract Located 2 km underground in SNOLAB, Sudbury, Canada, SNO+ is a large scale liquid scintillator experiment that primarily aims to search for neutrinoless double beta decay. Whilst has light and radioactive calibration sources external the inner volume, an internally deployed optical source necessary full characterization of detector model. A laser diffuser ball developed SNO previously demonstrated be effective device both water phase. Since introduction SNO+, material compatibility,...
<title>Abstract</title> Interval breast cancers (IBCs) are diagnosed between screening episodes. Understanding the biological differences IBCs and screen-detected breast-cancers (SDBCs) has potential to improve mammographic patient management. We analysed compared genomic landscape of 288 473 SDBCs by whole genome sequencing paired tumour-normal samples collected as part UK 100,000 Genomes Project. Compared SDBCs, were more likely be lobular, higher grade, triple negative. A aggressive...
Abstract Interval breast cancers (IBCs) are diagnosed between screening episodes. Understanding the biological differences IBCs and screen-detected breast-cancers (SDBCs) has potential to improve mammographic patient management. We analysed compared genomic landscape of 288 473 SDBCs by whole genome sequencing paired tumour-normal samples collected as part UK 100,000 Genomes Project. Compared SDBCs, were more likely be lobular, higher grade, triple negative. A aggressive clinical phenotype...
The SNO+ collaboration reports its first spectral analysis of long-baseline reactor antineutrino oscillation using 114 tonne-years data. Fitting the neutrino probability to observed energy spectrum yields constraints on mass-squared difference $\Delta m^2_{21}$. In ranges allowed by previous measurements, best-fit m^2_{21}$ is (8.85$^{+1.10}_{-1.33}$) $\times$ 10$^{-5}$ eV$^2$. This measurement continuing in next phases and expected surpass present global precision with about three years
Genome-wide association studies of colorectal cancer (CRC) have identified 170 autosomal risk loci. However, for most these, the functional variants and their target genes are unknown. Here, we perform statistical fine-mapping incorporating tissue-specific epigenetic annotations massively parallel reporter assays to systematically prioritize each CRC locus. We identify plausible causal loci, with a single variant 40. link these 208 by analyzing colon-specific quantitative trait loci...
The direction of individual $^8$B solar neutrinos has been reconstructed using the SNO+ liquid scintillator detector. Prompt, directional Cherenkov light was separated from slower, isotropic scintillation time information, and a maximum likelihood method used to reconstruct scattered electrons. A clear signal observed, correlated with angle. observation aided by period low primary fluor concentration that resulted in slower decay time. This is first event-by-event reconstruction high...
For many cancers there are few well-established risk factors. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide study (PheWAS) to identify causal relationships. We performed MR-PheWAS of breast, prostate, colorectal, lung, endometrial, oesophageal, renal, and ovarian cancers, comprising 378,142 cases 485,715 controls. To derive more comprehensive insight into disease aetiology we systematically mined the literature space for...
Located 2 km underground in SNOLAB, Sudbury, Canada, SNO+ is a large scale liquid scintillator experiment that primarily aims to search for neutrinoless double beta decay. Whilst has light and radioactive calibration sources external the inner volume, an internally deployed optical source necessary full characterization of detector model. A laser diffuser ball developed SNO previously demonstrated be effective device both water phase. Since introduction SNO+, material compatibility,...
<title>Abstract</title> <bold>Clear cell renal carcinoma (ccRCC) is the most common form of kidney cancer, but a comprehensive description its genomic landscape lacking. We report whole genome sequencing 778 ccRCC patients enrolled in 100,000 Genomes Project, providing detailed somatic mutational to date. identify new driver genes, which as well emphasising major role epigenetic regulation highlight additional biological pathways extending opportunities for drug repurposing. Genomic...