A5083074157- Health Systems, Economic Evaluations, Quality of Life
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Statistical Methods in Clinical Trials
- Meta-analysis and systematic reviews
- Hemoglobinopathies and Related Disorders
- Celiac Disease Research and Management
- Colorectal Cancer Screening and Detection
- Nursing Roles and Practices
- Delphi Technique in Research
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Smoking Behavior and Cessation
- Clinical practice guidelines implementation
- Diabetes Management and Research
- Ectopic Pregnancy Diagnosis and Management
- Global Health Workforce Issues
- Microscopic Colitis
- Advanced Causal Inference Techniques
- Radiation Dose and Imaging
- Obesity, Physical Activity, Diet
- Esophageal Cancer Research and Treatment
- Lymphoma Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
Clifton Hospital
2025
University of Bristol
2015-2024
MRC Integrative Epidemiology Unit
2021
MRC Epidemiology Unit
2021
University of Sheffield
2021
Universidad de Murcia
2021
NIHR Bristol Cardiovascular Biomedical Research Unit
2018
Liverpool Women's Hospital
2015-2017
University of Liverpool
2015-2017
As more complex meta-analytical techniques such as network and multivariate meta-analyses become increasingly common, further pressures are placed on reviewers to extract data in a systematic consistent manner. Failing do this appropriately wastes time, resources jeopardises accuracy. This guide (data extraction for meta-analysis (DECiMAL)) suggests number of points consider when collecting data, primarily aimed at preparing meta-analysis. Network (NMA), multiple outcomes analysis combining...
The National Institute for Health and Care Excellence (England's health technology assessment body) recommend the use of average treatment effect (ATE) as an estimand economic evaluations. However there is limited literature on methods to estimate ATE, particularly in case survival outcomes. Single-arm trials real-world data are playing increasing role assessments, oncology/rare diseases, generating a need new ATE estimation methods. This study aimed present adaptation utility this...
267 Background: Existing NMA in mHSPC compare treatments assuming homogeneity treatment effect modifiers across study populations. However, evidence suggests that these effects vary mHSPC. This employs the recent methods of multilevel network meta-regression (ML-NMR) and meta interpolation (NMI) to adjust for population differences predict relative estimates an ARASENS-like target population. Methods: We used a systematic literature review identify studies our on overall survival (OS)...
Background & AimsCeliac disease (CD) is a common yet underdiagnosed autoimmune with substantial long-term consequences. High-accuracy point-of-care tests for CD antibodies conducted at youth primary health care centers may enable earlier identification of CD, but evidence about the cost-effectiveness such strategies lacking. We estimated active case finding and mass screening compared clinical detection in Netherlands.MethodsA decision tree Markov model were used to simulate cohort...
Background Early pregnancy complications are common and account for the largest proportion of emergency work in gynaecology. Although early assessment units operate most UK acute hospitals, recent National Institute Health Care Excellence guidance emphasised need more research to identify configurations that provide optimal balance between cost-effectiveness, clinical effectiveness service- patient-centred outcomes [National (NICE). Ectopic Pregnancy Miscarriage: Diagnosis Initial Management...
Challenges can exist when framing the decision question in a cost-effectiveness analysis, particularly there is disagreement among experts on relevant comparators. Using prostate cancer screening and recent developments risk stratification, early-detection biomarkers, diagnostic technologies as case study, we report modified Delphi approach to handle decision-question uncertainty. The study involved two rounds of anonymous online questionnaires identify strategies that international...
Most guidelines in the UK, Europe and North America do not recommend organised population-wide screening for prostate cancer. Prostate-specific antigen-based can reduce cancer-specific mortality, but there are concerns about overdiagnosis, overtreatment economic value. The aim was therefore to assess cost effectiveness of eight potential strategies UK. We used a cost-utility analysis with an individual-based simulation model. model calibrated data from 10-year follow-up Cluster Randomised...
Brain tumour patients see their primary care doctor on average three or more times before diagnosis, so there may be an opportunity to identify 'at risk' earlier. Suspecting a brain diagnosis is difficult because tumour-related symptoms are typically non-specific. We explored the predictive value of referral guidelines (Kernick and NICE 2005) for imaging where suspected, in population-based patient group referred direct access CT head. A consensus panel reviewed whether non-tumour findings...
Objectives In young and middle-aged adults, there are three current options for aortic valve replacement (AVR), namely mechanical AVR (mechAVR), tissue (biological AVR) the Ross operation, with no clear guidance on best option. We aim to compare clinical effectiveness cost-effectiveness of procedure conventional in adults. Methods This is a systematic literature review meta-analysis options. Markov multistate model was adopted cost-effectiveness. Lifetime costs, quality-adjusted life years...
Crisaborole topical ointment, 2%, is a nonsteroidal, anti-inflammatory phosphodiesterase-4 (PDE4) inhibitor that approved for the treatment of mild-to-moderate atopic dermatitis (AD). The objective current analysis was to compare efficacy crisaborole 2% relative pimecrolimus 1%, tacrolimus 0.03% and 0.1% in patients aged ≥ 2 years with AD by comparing improvement Investigator's Static Global Assessment scores ( (ISGA 0/1 indicating "clear or almost clear"). ISGA selected as primary outcome...
( BJOG. 2016;123(9):1462–1470) Labor induction rates have been on the rise over past 20 years in many developed countries, including United Kingdom and States. Various methods are available for labor induction, choosing 1 method another depends several factors, such as a woman’s obstetric medical history, national guidelines local protocols. Techniques also differ their effectiveness risk of complications. The present study aimed to assess using comprehensive review synthesis evidence order...
Background Labour inductions have increased steadily over the past two decades, with overall rates in many countries now exceeding 20% of all births. We conducted a systematic review, network meta-analysis and cost-effectiveness analysis to determine which treatments for induction perform best on pre-specified safety efficacy outcomes. This poster reports outcomes reported trials.
Sickle cell disease (SCD) is a lifelong blood disorder affecting approximately 100,000 individuals in the United States (US). A number of new treatments have recently become available to improve SCD clinical outcomes, but it unclear how treatment innovations that reduce severity could affect patients' humanistic and economic outcomes.To answer this question, an online survey US adult residents with self-reported diagnosis was conducted. Humanistic outcomes based on health-related quality...