The ability to control how we process information by remembering that which is important and forgetting irrelevant essential maintain accurate, up-to-date memories. As such, memory success predicated on both successful intentional encoding forgetting. current study used an item-method directed paradigm elucidate the cognitive neural processes underlie while also examining relationship between them understand two may work together. Results indicated encoding-related in left inferior PFC...

Abstract Purpose Patients with sickle cell disease (SCD) may experience cell-related pain crises, also referred to as vaso-occlusive crises (VOCs), which are a substantial cause of morbidity and mortality. The study explored how VOC frequency severity impacts health-related quality life (HRQoL) work productivity. Methods Three hundred three adults SCD who completed an online survey were included in the analysis. answered questions regarding their VOCs, Adult Sickle Cell Quality Life...

Previous research has documented change in white matter tract integrity with increasing age. Both interhemispheric and intrahemispheric tracts that underlie language processing are susceptible to these age-related changes. The aim of the current study was explore age language-related as predictors cognitive task performance younger older adults. To this end, we carried out principal component analyses confirmatory factor analysis neuropsychological measures. We next a series regression used...

Tardive dyskinesia (TD) is a common but serious hyperkinetic movement disorder and side effect of antipsychotic medications used to treat bipolar (BD), major depressive (MDD), schizophrenia (SZ). The purpose this study was evaluate health-related quality life (HRQoL) in population with diagnoses for BD, MDD, or SZ by comparing patients TD (n = 197) those without 219). HRQoL each group also compared the general population.This employed cross-sectional web-based survey. assessed four...

Although healthy aging is generally characterized by declines in both brain structure and function, there variability the extent to which these changes result observable cognitive decline. Specific language, age-related differences language production are observed more frequently than comprehension, although associated with increased right prefrontal cortex activation older adults. The current paper explores system, integrating them theories of behavioral neural aging. Overall, data indicate...

Successful memory encoding depends on the ability to intentionally encode relevant information (via differential encoding) and forget that which is irrelevant inhibition). Both cognitive processes have been shown decline in aging are theorized underlie age-related deficits control of memory. The current study uses Directed Forgetting paradigm conjunction with fMRI investigate differences both processes, specific aim elucidating neural evidence supporting these deficits. Results indicate...

Abstract Introduction Older adults often show declines in phonological aspects of language production, particularly for low‐frequency words, but maintain strong semantic systems. However, there are different theories about the mechanism that may underlie such age‐related differences (e.g., transmission activation or inhibition). Methods This study used fMRI to investigate whether production associated with deficits inhibition deficits. We picture‐word interference paradigm examine picture...

Abstract This study describes the health-related quality of life (HRQoL) and symptom-specific functional impairment patients with paroxysmal nocturnal hemoglobinuria (PNH) in a real-world setting. US-based adults PNH treated parenterally administered complement inhibitor (PACI) for ≥ 6 months completed an online, cross-sectional, observational survey; subset also participated semi-structured qualitative interviews. The survey included PROMIS ® 29 + 2 Profile v2.1 (PROMIS 2) to measure HRQoL....

This study examined the content validity of SF-36v2® Health Survey (SF-36v2) in patients with AL amyloidosis using qualitative interviews physicians and patients. The included three distinct phases research: concept elicitation among physicians, patients, cognitive debriefing focused on areas health-related quality life that are affected by may be treatment, while patient debriefings aimed to confirm whether SF-36v2 instructions, recall period, items, response choices were comprehensive...

Intentional forgetting is posited to utilize both encoding and inhibition control what information enters long-term memory. Within the context of directed paradigm, evidence for role support has been examined primarily during encoding. Specifically, past studies have shown that when processes are intentionally inhibited, less likely be remembered. Despite recruitment such inhibitory processes, not all items successfully forgotten. The current study whether should forgotten (F items), but...

Abstract Background Patients with rheumatoid arthritis (RA) commonly experience pain despite the availability of disease-modifying treatments. Sleep disturbances are frequently reported in RA, often a contributing factor. The Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference and Disturbance item banks were initially developed to provide insights into patient sleep, respectively, though they not specifically intended for use RA populations. This study...

Children with sickle cell disease (SCD) experience a multiplex of disease-related symptoms and complications, including vaso-occlusive crises (VOCs), episodes characterized by extreme pain.A cross-sectional observational survey examined the health-related quality life (HRQoL) school experiences children SCD 2 months-11 years, burden experienced their caregivers, associations between these outcomes VOC frequency. Caregivers (N=167) in US completed Infant-Toddler Quality Life-Short Form 47...

Long-Evans hooded rats were trained to run an alternation pattern in a t-maze with low reward (1 pellet) the food cup of one arm and high (3 pellets) other arm. Single units intermediate deep layers superior colliculus recorded using moveable microelectrodes. Most showed activity that was associated retrieval, phasic increase either upon cessation running or insertion snout into cup. Some (16%) different patterns retrieval two magnitudes reward. Although 70% unimodal multimodal sensory...

Light-chain (AL) amyloidosis is a rare, progressive, and typically fatal disease. Health-related quality of life (HRQoL) has been shown to be significant prognostic factor associated with clinical outcomes such as survival response treatment. A better understanding how patterns HRQoL may prospectively costly healthcare resource utilization, emergency department (ED) visits inpatient hospitalizations, warranted.A secondary data analysis non-interventional, longitudinal online study patients...

Light-chain (AL) amyloidosis is a rare and often fatal disease caused by misfolded light chains, which form soluble toxic aggregates that deposit as fibrils (amyloid) in tissue organs, leading to significant permanent organ dysfunction. While nearly any or combination of organs can be affected AL amyloidosis, approximately 70% patients with experience amyloid deposits the cardiac myocytes, causes ventricular wall thickening leads restrictive cardiomyopathy subsequent congestive heart failure...

Sickle cell disease (SCD) is a lifelong blood disorder affecting approximately 100,000 individuals in the United States (US). A number of new treatments have recently become available to improve SCD clinical outcomes, but it unclear how treatment innovations that reduce severity could affect patients' humanistic and economic outcomes.To answer this question, an online survey US adult residents with self-reported diagnosis was conducted. Humanistic outcomes based on health-related quality...

Objective: To investigate tardive dyskinesia (TD) burden on patients’ quality of life (QoL) Background: TD, an often-irreversible movement disorder typically caused by exposure to antipsychotics, most commonly affects the face, mouth, and tongue may be debilitating. Due involuntary movements, patients with TD experience increased feelings stigma decreased QoL compared psychiatric disorders who do not have TD. Design/Methods: Adults clinician-confirmed schizophrenia, bipolar disorder, or...

Amyloid transthyretin (ATTR) amyloidosis is a rare, progressive, and fatal disease. The ATTR Patient Symptom Survey (ATTR-PSS) was previously developed through literature review concept elicitation input from clinicians patients revised after evaluation by patient focus group. This study further evaluated the content validity of ATTR-PSS qualitative cognitive debriefing interviews with patients.Seven 10 were interviewed individually regarding their overall impressions, clarity...