A5012104370- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- EEG and Brain-Computer Interfaces
- Complex Systems and Time Series Analysis
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Function and Risk Factors
- Pain Mechanisms and Treatments
- Temporomandibular Joint Disorders
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Sichuan University
2020-2024
West China Hospital of Sichuan University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Abstract Background and Hypothesis Disrupted control of brain state transitions may contribute to the diverse dysfunctions cognition, emotion, behavior that are fundamental schizophrenia. Control theory provides rationale for evaluating from a controllability perspective, which help reveal mechanism clinical features such as cognitive deficits associated with We hypothesized would be altered in patients schizophrenia, networks related symptomatology. Study Design Controllability measurements...
Obsessive-compulsive disorder (OCD) and schizophrenia have distinct but also overlapping symptoms. Few studies examined the shared disorder-specific disturbances in dynamic brain function 2 disorders.
Abstract Background Attention-deficit/hyperactivity disorder (ADHD) is a clinically heterogeneous neurodevelopmental defined by characteristic behavioral and cognitive features. Abnormal brain dynamic functional connectivity (dFC) has been associated with the disorder. The full spectrum of ADHD-related variation dynamics its association features remain to be established. Methods We sought identify patterns linked specific dimensions using sparse canonical correlation analysis across cohort...
Abstract Obsessive–compulsive disorder (OCD) is a debilitating and disabling neuropsychiatric disorder, whose neurobiological basis remains unclear. Although traditional static resting‐state magnetic resonance imaging (rfMRI) studies have found aberrant functional connectivity (FC) in OCD, alterations whole‐brain FC topological properties the context of brain dynamics remain relatively unexplored. The rfMRI data 29 patients with OCD 40 healthy controls were analyzed using group independent...
Studies of dynamic functional connectivity (dFC) and topology can provide novel insights into the neurophysiology brain dysfunction in schizophrenia its relation to core symptoms psychosis. Limited investigations these disturbances have been conducted with never-treated first-episode patients avoid confounds treatment or chronic illness. Therefore, we recruited 95 acutely ill, first-episode, examined dFC patterns relative healthy controls using resting-state magnetic resonance imaging a...
Obsessive-compulsive disorder (OCD) is a disabling neuropsychiatric whose neurobiological basis remains unclear. Magnetic resonance imaging (MRI) studies have reported functional and structural alterations of the anterior cingulate cortex (ACC) in OCD. In this study, we explored activity subregions ACC effective connectivity (EC) between whole brain We used Granger causality analysis (GCA) to identify direction information flow whether impact that was excitatory or inhibitory. performed...
Motivation: Autism spectrum disorder (ASD) and attention-deficit/hyperactivity (ADHD) are neurodevelopmental disorders with overlapping behavioral features genetic etiology. Exploring brain cortical thickness (CTh) could help understand the neurobiological basis which builds bridge between clinical manifestations liability of two disorders. Goal(s): To demonstrate common distinct CTh changes in ASD ADHD. Approach: Previous structural MRI studies analyzing ADHD were included compared by...
Sparse canonical correlation analysis (sCCA) was used to delineate multivariate relationship between dynamic functional connectivity (dFC) and behavior or cognition scores in a cohort of children with without Attention-Deficit/Hyperactivity Disorder (ADHD). We identified four distinct patterns dFC, each corresponded specific dimension (inattention/hyperactivity, somatization) cognitive function (inhibition flexibility, fluency memory). Altered dFC within the default mode network (DMN) DMN...
Temporal dynamics in degree centrality (DC) were measured to detect alterations of dynamic topological organization patients with obsessive-compulsive disorder (OCD) and schizophrenia (SZ). We found both OCD SZ showed decreased occurrence a state manifested as the highest sensory systems. Moreover, we observed common specific alteration temporal variability DC some brain regions, which correlated symptom severity patients, respectively.
Introduction There is a growing consensus on brain networks that it not immutable but rather dynamic complex system for adapting environment. The neuroimaging research studying how regions work collaboratively with methods had demonstrated its effectiveness in revealing the neural mechanisms of schizophrenia. Objectives To investigate altered functional topology first-episode untreated schizophrenia patients (SZs) and establish classification models to find objective imaging biomarkers....