A5080543095- Pharmaceutical and Antibiotic Environmental Impacts
- Water Treatment and Disinfection
- Antibiotics Pharmacokinetics and Efficacy
- RNA regulation and disease
- Atmospheric and Environmental Gas Dynamics
- Analytical chemistry methods development
- Endoplasmic Reticulum Stress and Disease
- Reservoir Engineering and Simulation Methods
- Pesticide and Herbicide Environmental Studies
- Water Systems and Optimization
- RNA Research and Splicing
- Urban Stormwater Management Solutions
- Constructed Wetlands for Wastewater Treatment
- Groundwater flow and contamination studies
- RNA and protein synthesis mechanisms
- Soil and Water Nutrient Dynamics
- Polyamine Metabolism and Applications
- CO2 Sequestration and Geologic Interactions
- Hydraulic Fracturing and Reservoir Analysis
- Wastewater Treatment and Nitrogen Removal
- Water Quality Monitoring and Analysis
- Air Quality Monitoring and Forecasting
- Cytomegalovirus and herpesvirus research
- Toxoplasma gondii Research Studies
- Coagulation and Flocculation Studies
Indiana University School of Medicine
2020-2024
Indiana University – Purdue University Indianapolis
2020-2024
Colorado State University
2006-2023
Indiana University Indianapolis
2022
Indiana University
2022
University of Indianapolis
2022
Indiana University Bloomington
2015-2019
Hamilton College
2019
Japan External Trade Organization
2006
The occurrence of 15 antibiotics belonging to three different groups, tetracyclines (TCs), sulfonamides (SAs), and macrolides (MLs), mainly used prevent or treat illness for humans also control disease promote the growth animals was studied in aqueous sediment matrices. result spatial temporal statistical analysis revealed that measured concentrations individual were significantly depending on sampling location time periods samples. High human-used detected downstream a wastewater treatment...
Abstract Diverse environmental insults induce the integrated stress response (ISR), which features eIF2 phosphorylation and translational control that serves to restore protein homeostasis. The kinase GCN2 is a first responder in ISR activated by amino acid depletion other stresses not directly related nutrients. Two mechanisms are suggested trigger an ordered process of activation during stress: monitoring via accumulating uncharged tRNAs or stalled colliding ribosomes. Our results suggest...
Research has verified the occurrence of veterinary antibiotics in manure, agricultural fields, and surface water bodies, yet little research evaluated antibiotic runoff from fields. The objective this study was to evaluate potential for contribute bodies a worst-case scenario. Our hypothesis that there would be significant differences concentrations, partitioning losses between sediment, pseudo-partitioning coefficients (ratio sediment concentration concentration) among antibiotics. An...
A stress adaptation pathway termed the integrated response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that eIF2 kinase GCN2 is required for sustained growth androgen-sensitive and castration-resistant models of PCa both vitro vivo, patient samples. Using RNA-seq transcriptome analysis a CRISPR-based phenotypic screen, was shown regulate expression over 60 solute-carrier ( SLC ) genes, those involved amino acid transport loss function...
Abstract The occurrence of human and veterinary pharmaceutical compounds in surface waters (e.g. streams, lakes reservoirs) is an important emerging environmental issue. There a need for robust, sensitive reliable analytical methods measuring these variety natural water wastewater matrices. This paper describes method the determination seven tetracycline (TC) six sulfonamide (SA) pristine wastewater‐influenced using solid‐phase extraction, LCQ Duo ion trap liquid chromatography/tandem mass...
Abstract Appropriate regulation of the Integrated stress response (ISR) and mTORC1 signaling are central for cell adaptation to starvation amino acids. Halofuginone (HF) is a potent inhibitor aminoacylation tRNAPro with broad biomedical applications. Here, we show that in addition translational control directed by activation ISR general nonderepressible 2 (GCN2), HF increased free acids translation genes involved protein biogenesis via sustained signaling. Deletion GCN2 reduced survival...
Toxoplasma gondii is a single-celled parasite that infects nucleated cells of warm-blooded vertebrates, including one-third the human population. The parasites are not cleared by immune response and persist in host converting into latent tissue cyst form.
In response to environmental stresses, cells invoke translational control conserve resources and rapidly reprogram gene expression for optimal adaptation. A central mechanism involves phosphorylation of the α subunit eIF2 (p-eIF2α), which reduces delivery initiator tRNA ribosomes. Because p-eIF2α is invoked by multiple protein kinases, each responding distinct this pathway named integrated stress (ISR). While lowers bulk translation initiation, many stress-related mRNAs are preferentially...
In drinking water treatment, destabilization of suspended particles through effective coagulation processes is critical for optimizing filtration performance. This study examined the impact pH (6.0−7.4), ζ-potential, and floc formation kinetics on particle removal during settling filtration. Increasing improved turbidity in process significantly increased ζ-potential range which performance was optimized. Although it possible to optimize (i.e., attain total < 10/mL) at each three levels...
Abstract Veterinary antibiotics, leached from contaminated manure that is applied as fertilizer, could be transported to surface water runoff or infiltrated groundwater after a significant rainfall. The main objective of this study was evaluate the transport behaviour ten antibiotics belonging four different groups in soil through column leaching under biotic and abiotic conditions. Among compared antibiotic groups, tetracyclines (TCs) were found have no residual leachate mainly remained...
Abstract Biodegradable organic matter formed during the ozonation of natural waters was fractionated into rapidly and slowly degradable components based on measurements biodegradable carbon (BDOC). The fraction (BDOCrapid) defined using specific BDOC reactor incubation time that resulted in biodegradation similar to a pilot scale biofilter. Ozone dose found increase formation BDOCrapid up transferred 1.0 1.5 mg O3/mg DOC. This insensitive DOC quantity or character. BDOCslow not sensitive...