A5079652690- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
Post Graduate Institute of Medical Education and Research
2023
Central University of Punjab
2018-2022
Jawaharlal Nehru University
2020
Leishmaniasis is a neglected tropical disease endemic in over 90 countries. The has two main pathologies; cutaneous leishmaniasis (CL) that generally self-heals, and visceral (VL) fatal if untreated. majority of VL cases, concentrated on the Indian subcontinent (ISC) East Africa, are caused by
The clinical manifestation of leishmaniasis has historically been determined by the Leishmania species involved. However, recent emergence novel lineages caused atypical pathologies. We isolated and characterized 2 new donovani parasites causing cutaneous in Himachal Pradesh, India.
Abstract We conducted a molecular study of parasite sequences from cohort cutaneous leishmaniasis patients in Himachal Pradesh, India. Results revealed atypical disease caused by Leishmania donovani parasites. L. variants causing manifestations this region are different those visceral northeastern
Himachal Pradesh in India is a newer endemic state with co-existence of cutaneous and visceral leishmaniasis. The leishmaniasis cases are on an increase the region reported to be unusually caused by Leishmania donovani limited molecular validation. In order molecularly characterize causative parasite disease, specific Internal-Transcribed Spacer 1 (ITS1) PCR RFLP sequence analysis was performed skin lesional biopsies from patients. Interestingly, we found presence Leptomonas seymouri 38.5%...
Leishmaniasis continues to afflict known and newer endemic sites despite global efforts towards its control elimination. In this regard, the emergence of with unusual disease formats is recognized wherein Leishmania donovani complex classically cause visceral demonstrated cutaneous manifestation. context, atypical leishmaniasis (CL) cases caused by L. genetic variants from state Himachal Pradesh (HP) in India are beginning be understood terms parasite determinants. The CL manifestation...