A5046673589- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Pancreatitis Pathology and Treatment
- Neonatal Health and Biochemistry
- Trauma and Emergency Care Studies
- Emergency and Acute Care Studies
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Vascular Procedures and Complications
- Drug Transport and Resistance Mechanisms
- Organ Transplantation Techniques and Outcomes
University of Southern California
2017-2021
Children's Hospital of Los Angeles
2017-2021
University of Michigan
2017
In patients with biliary atresia (BA), the extent of intrahepatic fibrosis negatively correlates successful surgical bypass congenital cholangiopathy as well subsequent transplant‐free survival. We recently linked expansion a population prominin‐1 ( Prom1 )‐expressing hepatic progenitor cells to fibrogenesis. Herein, we hypothesized that ‐expressing play role in BA‐associated fibrosis. Rhesus rotavirus (RRV)‐mediated experimental BA was induced newborn mice homozygous for transgene...
Cholestatic liver injury is associated with intrahepatic biliary fibrosis, which can progress to cirrhosis. Resident hepatic progenitor cells (HPCs) expressing Prominin-1 (Prom1 or CD133) become activated and participate in the expansion of cholangiocytes known as ductular reaction. Previously, we demonstrated that atresia, Prom1(+) HPCs are present within developing fibrosis null mutation Prom1 significantly abrogates fibrogenesis. Here, hypothesized these Prom1-expressing promote...
Five established clearing protocols were compared with a modified and simplified method to determine an optimal reagent for three-dimensionally visualizing fluorophores in the murine liver, challenging organ clear. We report successful of whole liver lobes by modification protocol (UbasM) using only Ub-1, urea-based amino sugar reagent, simpler that requires 24-h processing time. With Ub-1 alone, we observed sufficiently preserved tissue structure three dimensions along excellent...