A5044943705- Shoulder Injury and Treatment
- Stroke Rehabilitation and Recovery
- Trauma and Emergency Care Studies
- Esophageal Cancer Research and Treatment
- Cardiac Arrest and Resuscitation
- RNA modifications and cancer
- Simulation-Based Education in Healthcare
- Shoulder and Clavicle Injuries
- Tendon Structure and Treatment
- Acute Ischemic Stroke Management
- Sports injuries and prevention
- Congenital Diaphragmatic Hernia Studies
- Air Quality and Health Impacts
- Botulinum Toxin and Related Neurological Disorders
- Tracheal and airway disorders
- Emergency and Acute Care Studies
- Neonatal Respiratory Health Research
- Abdominal Trauma and Injuries
- Patient Safety and Medication Errors
- Cardiovascular Health and Disease Prevention
- Cerebral Palsy and Movement Disorders
- Health Literacy and Information Accessibility
- Social Media in Health Education
- Advertising and Communication Studies
- Airway Management and Intubation Techniques
Southern California Clinical and Translational Science Institute
2017-2021
University of Southern California
2010-2020
Children's Hospital of Los Angeles
2018-2020
LAC+USC Medical Center
2020
Stroke patients with mild-moderate upper extremity motor impairments and minimal sensory cognitive deficits provide a useful model to study recovery improve rehabilitation. Laboratory-based investigators use lesioning techniques for similar goals.To determine whether stroke lesions in an rehabilitation trial cohort match from the preclinical models used drive translational research.Clinical neuroimages 297 participants enrolled Interdisciplinary Comprehensive Arm Rehabilitation Evaluation...
Background— Nitric oxide (NO) plays an important role in cardiovascular health by maintaining and regulating vascular tone blood flow. Epigenetic regulation of NO synthase (NOS), the genes responsible for production, may affect disease, including development atherosclerosis children. Methods Results— We measured percentage DNA methylation using bisulfite conversion pyrosequencing assays on from buccal cells provided 377 participants Children’s Health Study whom carotid artery intima-media...
BACKGROUND Early tracheostomy has been associated with shorter hospital stay and fewer complications in adult trauma patients. Guidelines for have not established children severe traumatic brain injury (TBI). The purpose of this study was to (1) define nationwide trends time extubation (2) determine if early is decreased length TBI. METHODS Records (<15 years) TBI (head Abbreviated Injury Severity [AIS] score ≥3) who were mechanically ventilated (>48 hours) obtained from the National...
Background: Research imaging costs limit lesion-based analyses in already expensive large stroke rehabilitation trials. Despite the belief that lesion characteristics influence recovery and treatment response, prior studies have not sufficiently addressed whether features are an important consideration motor trial design. Objective: Using clinically-obtained neuroimaging, evaluate how relate to upper extremity (UE) response therapy a UE trial. Methods: We reviewed lesions from 297...
O-29C4-3 Background/Aims: Prenatal exposure to air pollution is associated with adverse birth outcomes such as low weight. We sought investigate whether prenatal high levels of particulate matter (PM2.5) from large wildfires were also negatively outcomes, independent background levels. Methods: In 2003, several occurred across 6 counties in Southern California, burning more than 750,000 acres over days. investigated the effect wildfire-generated PM2.5 on using California vital statistics...
Department of Dermatology Keck School Medicine University Southern California Los Angeles [email protected] Children's Hospital Angeles, Clinical and Translational Science Institute The authors have no conflicts interest to declare. This study was supported by grant numbers UL1TR001855 UL1TR000130 from the National Center for Advancing US Institutes Health. content is solely responsibility does not necessarily represent official views
For phase III RCTs, sample heterogeneity is useful for both generalizability of findings and providing insight into treatment effects specific subgroups. Prior studies in stroke rehabilitation have rarely explored differences intervention between racial ethnic subgroups across participating sites. We examined participant characteristics centers, with the hypothesis that strategic use a multi-center structure 3 distinct urban geographical areas (Atlanta, GA, Los Angeles, CA Washington, DC)...
INTRODUCTION: Esophageal squamous cell carcinoma (ESCC) accounts for 90% of esophageal cancers worldwide but is less common in the developed world. Our aim was to report patient and tumor characteristics individuals diagnosed with ESCC within underserved Los Angeles County population. METHODS: Review hospital pathology database identified 65 cases patients ages 18-80 a pathologic diagnosis from 2003-2015. A retrospective chart review electronic health records conducted excluding unknown...
Defining factors associated with severe reflux esophagitis allows for identification of subgroups most at risk complications strictures and esophageal malignancy. We hypothesized there might be unique clinical features in patients a predominantly Hispanic population large, safety-net hospital. Define endoscopic This is retrospective comparative study outpatients hospitalized identified mild (Los Angeles Grade A/B) C/D) through an endoscopy database review. The electronic medical record was...
Abstract Introduction: Esophageal squamous cell carcinoma (ESCC) accounts for 90% of esophageal cancers worldwide but is less common in the developed world. Our aim was to report patient and tumor characteristics individuals diagnosed with ESCC within underserved Los Angeles County population. Methods: Review hospital pathology database identified 65 cases patients ages 18-80 a pathologic diagnosis from 2003-2015. A retrospective chart review electronic health records conducted excluding...