A5038331501- Cystic Fibrosis Research Advances
- Genomics and Rare Diseases
- Cellular Mechanics and Interactions
- Collagen: Extraction and Characterization
- Neonatal Respiratory Health Research
- Immunodeficiency and Autoimmune Disorders
- Iron Metabolism and Disorders
- Child Nutrition and Water Access
- 3D Printing in Biomedical Research
University of Tehran
2021-2024
Objectives: Cystic fibrosis (CF) is the most prevalent autosomal recessive disorder among Caucasians. Mutations in cystic transmembrane conductance regulator (CFTR) gene cause this pathology. We, therefore, aimed to describe CFTR mutations and their geographical distribution Iran. Method: The mutation spectrum for 87 families from all Iranian ethnicities was collected using ARMS PCR, Sanger sequencing, MLPA. Results: were identified 95.8% of cases. This dataset revealed that frequent...
Cells continuously sense and react to mechanical cues from their surrounding matrix, which consists of a fibrous network biopolymers that influences fate behavior. Several powerful methods employing magnetic control have been developed assess the micromechanical properties within extracellular matrix (ECM) models hosting cells. However, many these are limited in-plane sensing actuation, does not allow be probed its full 3D context. Moreover, little attention has given factors specific model...
Cystic fibrosis (CF) is an autosomal recessive disease caused by the inheritance of two mutant cystic transmembrane conductance regulator (CFTR) alleles, one from each parent. Autosomal disorders are rarely associated with germline mutations or mosaicism. Here, we propose a case paternal mutation causing CF. The subject also had identifiable maternal allele. We identified compound heterozygous variants in proband through Sanger sequencing, and
Reporting Two Novel Mutations in Iranian Families with Cystic Fibrosis, Molecular and Bioinformatic Analysis