Biohybrid bacteria–based microrobots are increasingly recognized as promising externally controllable vehicles for targeted cancer therapy. Magnetic fields in particular have been used a safe means to transfer energy and direct their motion. Thus far, the magnetic control strategies this context rely on poorly scalable field gradients, require active position feedback, or ill-suited diffuse distributions within body. Here, we present torque–driven scheme enhanced transport through biological...

Magnetically controlled synthetic and living micropropellers stir up nanoparticles for enhanced drug transport.

Rotating magnetic fields enable biomedical microrobots to overcome physiological barriers and promote extravasation accumulation in tumors. Nevertheless, targeting deeply situated tumors requires suppression of off-target actuation healthy tissue. Here, we investigate a control strategy for applying spatially selective torque density by combining rotating with magnetostatic selection fields. Taking magnetotactic bacteria as diffuse torque-based actuators, numerically model suppression,...

Modulation of neuronal oscillations holds promise for the treatment neurological disorders. Nonetheless, conventional stimulation in a continuous open-loop manner can lead to side effects and suboptimal efficiency. Closed-loop strategies such as phase-locked aim address these shortcomings by offering more targeted modulation. While theories have been developed understand neural response stimulation, their predictions not thoroughly tested using experimental data. Using mechanistic coupled...

Alterations of blood flow patterns strongly correlate with arterial wall diseases such as atherosclerosis and aneurysm. Here, a simple, pumpless, close-loop, easy-to-replicate, miniaturized device is introduced to concurrently expose 3D engineered vascular smooth muscle tissues high-velocity pulsatile versus low-velocity disturbed conditions. Two regimes are distinguished, one that promotes elastin impairs collagen I assembly, while the other assembly. This latter extracellular matrix (ECM)...

Coronary arteries, which are branched from the sinuses, have tangible effects on hemodynamic performance of bileaflet mechanical heart valve (BMHV), especially in diastolic phase. To better understand this issue, a computer model ascending aorta including realistic sinus shapes and coronary arteries has been generated study order to investigate BMHV during diastole. Three-dimensional transient numerical analysis is conducted simulate blood flow through hinges under assumption non-Newtonian...

Abstract Magnetic actuation offers a means to wirelessly control flow in ferrofluids for applications including microfluidic pumping and targeted drug delivery. Despite the promise of these concepts, practical use synthetic as actuators frequently requires high concentrations is hindered by low ferrohydrodynamic coupling efficiency inhomogeneous fields. Inspired magnetic properties hydrodynamic forms displayed magnetotactic bacteria (MTB), this work studies microbes living, self‐replicating...

Due to the difficulty of targeting systemically delivered therapeutics for cancer, interest has grown in exploiting biological agents enhance tumor accumulation and mediate localized drug delivery. Equipped with onboard sensing active motility, some cells respond specific cues microenvironment, making them ideal candidates smart cancer therapy. Herein, recent progress developments are presented on use four most promising cell‐based systems delivery—immune cells, stem platelets, bacteria....

Cells continuously sense and react to mechanical cues from their surrounding matrix, which consists of a fibrous network biopolymers that influences fate behavior. Several powerful methods employing magnetic control have been developed assess the micromechanical properties within extracellular matrix (ECM) models hosting cells. However, many these are limited in-plane sensing actuation, does not allow be probed its full 3D context. Moreover, little attention has given factors specific model...

Single domain magnetic nanoparticles are increasingly investigated as actuators of biological and chemical processes that respond to externally applied fields. Although their localized effects have often been attributed nanoscale heating, recent experimental evidence suggests the need consider alternative hypotheses. Here, using stochastic Landau–Lifshitz–Gilbert equation finite element modeling, we investigate critically examine an hypothesis may instead involve induced electric fields...

Abstract Rotating magnetic fields (RMFs), when used to actuate biomedical microrobots for targeted delivery tumors, have been shown enable them overcome physiological barriers and promote their accumulation penetration into tissue. Nevertheless, directly applying a RMF deeply situated target site also leads off-target actuation in surrounding healthy Here, we investigate an open-loop control strategy delivering torque density diffuse distributions of at focal points by combining RMFs with...

Many researchers have investigated how to increase the overall efficiency of solar-driven thermal systems. Several key parameters, such as collector and storage tank characteristics, may impose some constraints on annual solar fraction (ASF) In this paper, behaviour integrating phase change material (PCM) in SDHW systems is modelled optimized numerically. Coupled partly stratified PCM-embedded governing equations are utilized simulate performance system. The developed code presents monthly...

Abstract Bacterial microrobots combining self-propulsion and magnetic guidance are increasingly recognized as promising drug delivery vehicles for targeted cancer therapy. Thus far, control strategies have either relied on poorly scalable field gradients or employed directing fields with propulsive forces limited by the bacterial motor. Here, we present a torque-driven actuation scheme based rotating to wirelessly Magnetospirillum magneticum AMB-1 bearing versatile liposomal cargo. We...

Abstract Background Modulation of neuronal oscillations holds promise for the treatment neurological disorders. Nonetheless, stimulating populations in a continuous open-loop manner can lead to side effects and suboptimal efficiency. Closed-loop strategies such as phase-locked stimulation aim address these shortcomings by offering more targeted modulation. While theories have been developed understand neural response stimulation, their predictions not thoroughly tested using experimental...

Abstract Bacteria‐based agents are emerging as promising tools for cancer therapy due to their ability actively target tumors, trigger localized inflammation, and induce tumor regression. There has been growing interest in using bacteria that responsive external cues, such magnetic fields, facilitate the formation of robust colonies tumors achieve threshold clinical efficacy. Several studies have demonstrated potential innately magnetically bacteria, known magnetotactic (MTB), steerable...

Abstract Single domain magnetic nanoparticles are increasingly investigated as actuators of biological and chemical processes that respond to externally applied fields. Although their localized effects frequently attributed nanoscale heating, recent experimental evidence casts doubt on the existence temperature gradients in these systems. Here, using stochastic Landau-Lifshitz-Gilbert equation finite element modelling, we critically examine an alternative hypothesis may be mediated by...

Systems utilizing renewable energies can provide clean, reliable, secure and competitive energy products to help meet the rapidly increasing global demand.This paper explores reduction of pollutant greenhouse gas emissions by solar Zero Energy Building (ZEB) for a typical detached house in Tehran.Brief description about design such building is presented.Regarding fact that electricity natural consumption are covering 75 % Iran, this analysis includes two points view, direct an indirect...