A5060847910- Cancer Research and Treatments
- Geomagnetism and Paleomagnetism Studies
- Characterization and Applications of Magnetic Nanoparticles
- Protist diversity and phylogeny
- Enzyme Structure and Function
- Micro and Nano Robotics
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Collagen: Extraction and Characterization
- Modular Robots and Swarm Intelligence
- Methane Hydrates and Related Phenomena
- Microfluidic and Bio-sensing Technologies
- Protease and Inhibitor Mechanisms
- Calcium Carbonate Crystallization and Inhibition
- Cellular Mechanics and Interactions
- Hydrogen's biological and therapeutic effects
ETH Zurich
2020-2024
The Geneva Association
2023
Rotating magnetic fields enable biomedical microrobots to overcome physiological barriers and promote extravasation accumulation in tumors. Nevertheless, targeting deeply situated tumors requires suppression of off-target actuation healthy tissue. Here, we investigate a control strategy for applying spatially selective torque density by combining rotating with magnetostatic selection fields. Taking magnetotactic bacteria as diffuse torque-based actuators, numerically model suppression,...
Interest has grown in harnessing biological agents for cancer treatment as dynamic vectors with enhanced tumor targeting. While bacterial traits such proliferation tumors, modulation of an immune response, and local secretion toxins have been well studied, less is known about bacteria competitors nutrients. Here, we investigated the use a strain living iron chelator, competing this nutrient vital to growth progression. We established vitro co-culture system consisting magnetotactic...
Abstract Rotating magnetic fields (RMFs), when used to actuate biomedical microrobots for targeted delivery tumors, have been shown enable them overcome physiological barriers and promote their accumulation penetration into tissue. Nevertheless, directly applying a RMF deeply situated target site also leads off-target actuation in surrounding healthy Here, we investigate an open-loop control strategy delivering torque density diffuse distributions of at focal points by combining RMFs with...
The use of bacteria in cancer immunotherapy has the potential to bypass many shortcomings conventional treatments. ability anaerobic preferentially accumulate and replicate hypoxic regions solid tumors, as a consequence bacterial metabolic needs, is particularly advantageous key boosting their immunostimulatory therapeutic actions situ. While several these traits are well-studied, little known about competition for nutrients its effect on cells which could serve another potent innate...
Effects of magnetically controlled cyclic deformation on cancer cell invasion.
Abstract Bacteria‐based agents are emerging as promising tools for cancer therapy due to their ability actively target tumors, trigger localized inflammation, and induce tumor regression. There has been growing interest in using bacteria that responsive external cues, such magnetic fields, facilitate the formation of robust colonies tumors achieve threshold clinical efficacy. Several studies have demonstrated potential innately magnetically bacteria, known magnetotactic (MTB), steerable...
Abstract Interest has grown in harnessing biological agents for cancer treatment as dynamic vectors with enhanced tumor targeting. While bacterial traits such proliferation tumors, modulation of an immune response and local secretion toxins have been well studied, less is known about bacteria competitors nutrients. Here, we investigated the use a strain living iron chelator, competing this nutrient vital to growth progression. We established vitro co-culture system consisting magnetotactic...
Abstract Bacteria are increasingly envisioned as living agents that can be administered to patients carry out therapeutic actions. Interest has been growing over the past years in harnessing these microorganisms for cancer treatment dynamic vectors with enhanced tumor-targeting properties. While bacterial traits, such modulation of an immune response, local secretion toxins, and proliferation tumors have well studied, less is known about bacteria competitors nutrients. We, therefore,...
Abstract The use of bacteria in cancer immunotherapy has the potential to bypass many shortcomings conventional treatments. ability anaerobic preferentially accumulate and replicate hypoxic regions solid tumors, as a consequence bacterial metabolic needs, is particularly advantageous key boosting their immunostimulatory therapeutic actions situ. While several these traits are well-studied, little known about competition for nutrients its effect on cells which could serve another potent...