Design parameters of prefilled pens, known as autoinjectors within the medical device community, can affect pen's functioning and user experience. This study compares performance two 2 mL pen devices: lebrikizumab (125 mg/mL) dupilumab (150 mg/mL). We recorded force acoustic signals during administration from devices performed high-speed video recording needle insertion drug delivery. Measurements were reported in these categories: (i) The kinematics movement captured by cameras (ii)...

During water entry, a projectile can entrain an air cavity that trails behind it. Most previous studies focus on the formation and pinch-off dynamics of cavity, but only few have investigated long-term after pinch-off. In this study, we examine ripple following generated by cone, with different cone angles impact velocities. The amplitude wavelength these ripples are measured, force is experimentally determined. It was observed increase linearly velocity, which predicted our acoustic model...

Splashes are ubiquitous in nature and engineering, they govern processes from diving to ocean oxygenation. Yet, date, it is not understood when or why a splash sometimes seals does not. Supported by theory experimental observations, detailed analysis presented, critical dimensionless number that predicts the occurrence of surface seal uncovered.

Objective: Autoinjectors are a convenient and efficient way to self-administer subcutaneous injections of biopharmaceuticals. Differences in device mechanical design can affect the autoinjector functionality performance. This study investigates performance differences two single-spring-actuated autoinjectors.Methods: We compare between Emgality (120 mg/mL) Aimovig (140 devices from an engineering point view at test conditions: room (25 C[Formula: see text]) storage (5 temperatures. employ...

Bubble formation and growth play an important role in various processes industries, where the dispersion of gas bubbles a liquid medium occurs frequently. In this paper, formation, growth, detachment produced from submerged needle water are numerically experimentally investigated. The effect injected properties on bubble characteristics, including diameter, contact angle, frequency is evaluated. particular, changes characteristics during injection process investigated for three different...

Understanding bubble oscillations is critical in science, engineering and medicine. An important aspect of dynamics the transition from spherical to non-spherical when subjected external stimuli like time-dependent pressure fields. The mechanisms underpinning this process are not well understood for complex fields encountered most applications. Here, we perform high-fidelity numerical simulations a non-condensable gas induced by acoustic field generated collapse nearby cavitation bubble. We...

The fluid dynamics in the far-field of liquid sprays involves a wide range spatio-temporal scales; challenging experimental observation and numerical modeling alike. Here we show how combination multiple imaging approaches, targeted to different scales, can provide useful insight into this class flows. We performed multi-scale measurements an upward-facing spray issued large quiescent air chamber by hollow-cone atomizer. Time-resolved planar laser was carried out simultaneously over two...

In this paper, an experimental study on the flow patterns of two-phase air-light oil is performed in a 20 mm diameter pipe with length 6 m different orientations angles range -45 to +45. The regimes are captured by high speed camera. experiments, air viscosity 0.019 mPa.s and density 1.2 Kg/m3 light 2.6 840 used. During observed such as bubbly, slug, smooth stratified, wavy annular flows. Flow inclination inspected pattern maps proposed for every angle. addition, comprehensive major forces...

This paper analyses adiabatic gas bubble formation, growth, and detachment which are produced from a submerged needle in water with the aim of elucidating impact surface tension on properties.A simulation model is utilized to enable examination problem for mentioned parameter.The numerical results compared experimental observations validation purposes.The results, including changes properties during process, recorded comprehensive research different tensions applied understand effect this...

Understanding the interface motion and hydrodynamic shear induced by liquid sloshing during insertion stage of an autoinjector can help improve drug product administration. We perform experiments to investigate interfacial due acceleration deceleration syringes. The goal is explore role fluid properties, air gap size, syringe on dynamics caused activation. used a simplified platform record without any view obstruction. Water silicone oil with same viscosity are as model fluids. Particle...

Liquid perfluorocarbon-based nanodroplets are stable enough to be used in extravascular imaging, but provide limited contrast enhancement due their small size, incompressible core, and acoustic impedance mismatch with biological fluids. Here we show a novel approach overcoming this limitation by using heating–cooling cycle, which will refer as thermal modulation (TM), induce echogenicity of otherwise poorly echogenic without triggering transient phase shift. We apply high-boiling point...

Systems utilizing renewable energies can provide clean, reliable, secure and competitive energy products to help meet the rapidly increasing global demand.This paper explores reduction of pollutant greenhouse gas emissions by solar Zero Energy Building (ZEB) for a typical detached house in Tehran.Brief description about design such building is presented.Regarding fact that electricity natural consumption are covering 75 % Iran, this analysis includes two points view, direct an indirect...