About
Contact & Profiles
A5040688501
Research Areas
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
Huazhong University of Science and Technology
2019-2021
Abstract G protein-coupled receptors (GPCRs) can integrate extracellular signals via allosteric interactions within dimers and higher-order oligomers. However, the structural bases of these remain unclear. Here, we use GABA B receptor heterodimer as a model it forms large complexes in brain. It is subjected to genetic mutations mainly affecting transmembrane 6 (TM6) involved human diseases. By cross-linking, identify interfaces B1 -GABA B2 , well interactions. Our data are consistent with an...
10.1038/s41467-019-10834-5
article
EN
cc-by
Nature Communications
2019-06-24
Distinct G protein–mediated pathways mediate neuroprotective GABA B receptor signaling.
10.1126/scisignal.aaz4112
article
EN
Science Signaling
2021-10-19
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