A5001221373- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Microscopic Colitis
- Health and Medical Studies
- PI3K/AKT/mTOR signaling in cancer
- Myasthenia Gravis and Thymoma
- Polyamine Metabolism and Applications
- Drug Transport and Resistance Mechanisms
- Inflammatory Bowel Disease
- Vibrio bacteria research studies
- Advanced Radiotherapy Techniques
- Escherichia coli research studies
- Autoimmune Neurological Disorders and Treatments
- Cancer Research and Treatments
- Effects of Radiation Exposure
- Renal Diseases and Glomerulopathies
- Radiation Dose and Imaging
- Peripheral Neuropathies and Disorders
- Trace Elements in Health
- Blood Coagulation and Thrombosis Mechanisms
- Systemic Lupus Erythematosus Research
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021
Charité - Universitätsmedizin Berlin
2017-2021
Medical University of Vienna
1987
<h3>Objective</h3> α-Haemolysin (HlyA) influences host cell ionic homeostasis and causes concentration-dependent lysis. As a consequence, HlyA-producing <i>Escherichia coli</i> is capable of inducing 'focal leaks' in colon epithelia, through which bacteria antigens translocate. This study addressed the role HlyA as virulence factor pathogenesis colitis according to 'leaky gut' concept. <h3>Design</h3> To action colon, we performed oral administration HlyA-expressing <i>E coli</i>-536 its...
Abstract Zinc homoeostasis exerts protective effects in inflammatory intestinal diseases and zinc supplementation has been successfully used for treating infectious diarrhoea. This study aimed at a characterisation of on focal leak induction by α-haemolysin (HlyA)-producing Escherichia coli (E. coli) as mechanism colitis. We conducted vivo experiments oral challenge gnotobiotic mice colonised with HlyA-expressing E. -536. Mice were either fed defined normal or high diet to analyse...
Escherichia coli (E. coli) of the B2 phylotype reside in human and animal intestines. The bacteria possess pathogenicity factors such as α-hemolysin (HlyA) that can induce intestinal epithelial leaks. We addressed questions which host cell processes were dysregulated by E. HlyA potentiate diseases. colon carcinoma line Caco-2 was infected HlyA+ coli. Cell polarity regulation analyzed live imaging for phosphatidylinositol-4,5-bisphosphate (PIP2) abundance. In monolayers, transepithelial...
Antineuronal antibodies can be associated with both gastrointestinal (GI) and brain disorders. For example, against the potassium channel subunit dipeptidyl-peptidase-like protein-6 (DPPX) bind to neurons in central nervous system (CNS) myenteric plexus cause encephalitis, commonly preceded by severe unspecific GI symptoms. We therefore investigated prevalence of antineuronal indicative treatable autoimmune CNS etiologies patients.Serum samples 107 patients (Crohn's disease n = 42,...
Arterial and venous thrombosis frequently occur in patients with lupus anticoagulant. We investigated anticoagulant the possible association between protein S:Ag deficiency and/or anticardiolipin antibodies a history of thrombosis. In 27 (8 19 without thromboembolic disease) free was determined immunoelectrophoresis PEG 8000 precipitated plasma. Anticardiolipin were measured 22 (10 thromboembolism) by means solid phase radioimmunoassay. Free plasma normal or elevated 25 slightly decreased...
''Schickt das Kind zum Röntgen!“ Ist die rechtfertigende Indikation erst gestellt, so liegt es in der Verantwortung des Radiologen und MTRA Untersuchung nach den Leitlinien Bundesärztekammer durchzuführen, dass applizierte Dosis für gering wie möglich ist. Hilfreich ist hier, wenn physikalischen Wechselwirkungen zwischen Strahlung dem kleinen Patienten nicht nur bekannt sind, sondern ein „Bild“ Köpfen verantwortungsvollen Personals existiert, Röntgenstrahlung im absorbiert gestreut wird....