A5037995106- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Metabolism, Diabetes, and Cancer
- Prenatal Substance Exposure Effects
- Autophagy in Disease and Therapy
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neural Engineering
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Sirtuins and Resveratrol in Medicine
- Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Sleep and Wakefulness Research
- Medicinal Plants and Neuroprotection
- Curcumin's Biomedical Applications
- Sulfur Compounds in Biology
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
Tehran University of Medical Sciences
2017-2024
University of Tehran
2022
Ahvaz Jundishapur University of Medical Sciences
2014-2016
Shahid Beheshti University of Medical Sciences
2011-2013
Ilam University
2011
Context Metformin induced AMP-activated protein kinase (AMPK) and protected neurons in cerebral ischaemia. Objective This study examined pretreatment with metformin activation of AMPK molecular behavioral levels associated memory. Materials methods Rats were pretreated (200 mg/kg) for 2 weeks 4-vessels occlusion global ischaemia was induced. Three days after ischaemia, memory improvement done by passive avoidance task neurological scores evaluated. The amount Brain-Derived Neurotropic Factor...
Abstract In the present study, we examined effects of intracerebroventricular administration extracellular signal‐regulated protein kinase‐ ( ERK ) and p38‐specific inhibitors, U 0126 PD 169316, respectively, on apoptosis induced by amyloid beta A β) in rats. To investigate these compounds, evaluated intracellular signalling pathways apoptosis, as well inflammatory antioxidant pathways, 7 20 days after β injection. We found that caspase‐3 B ax/ cl‐2 ratio, two hallmarks were significantly...
Background: Radiation-induced heart injury can lead to increased risk of failure, attack, and ischemia. Some studies proposed IL-4 IL-13 as two important cytokines that are involved in late effects ionizing radiation. On the other hand, these may, through upregulation Duox1 Duox2, induce chronic oxidative stress, inflammation, fibrosis. In this study, we evaluated Duox2 pathways hearts following chest irradiation rats then detected possible attenuation them by melatonin. Materials Methods:...
Abstract Objective I/R and its subsequent reactive hyperemia results in different adverse effects such as brain edema BBB disruption. AMPK activation has been perceived one of the target factors for treatment. We investigated effect Met (an activator) on some physiological parameters including vascular responses, hyperemia, disruption, electrophysiological activity following tGCI. Methods Rats were pretreated with two weeks CC was administered half an hour before Brain evaluated ischemia....
In the current study, our specific aim was to characterize Klotho protein and expression levels in hippocampus prefrontal cortex of old rats treated with different diets (high-fat, high-protein, low-calorie, high-protein low-calorie).Rats were high-fat, low-calorie for 10 weeks then behavioral molecular assessments evaluated.Statistical analysis showed percentage open arm time increased groups compared control (old-C) rats. The entries group old-C body weight serum triglyceride decreased...
Abstract Deep brain stimulation (DBS) has been proposed as a promising intervention for patients with treatment‐refractory substance use disorder. Here, we investigated if high‐frequency DBS in the lateral hypothalamic area (LHA) could affect drug‐induced reinforcement. Rats were bilaterally implanted bipolar electrodes LHA and trained to morphine conditioned place preference. (monophasic square pulses, 130 Hz, 100‐microsecond pulse duration 150 μA) was applied during morphine‐pairing trials...
The role of nitric oxide/protein kinase G (NO/PKG) in neurodegenerative disorders is controversial different circumstances. PKG affects neurons both by itself and as a result increased NO concentration. In this study, we examined the influence on spatial memory intrahippocampal administration three concentrations KT5823 inhibitor. Morris water maze (MWM) was used for evaluation behavioral alterations. We also measured apoptosis autophagy markers two probable interfering pathways with...
Metformin exerts its effect via AMP-activated protein kinase (AMPK), which is a key sensor for energy homeostasis that regulates different intracellular pathways. attenuates oxidative stress and cognitive impairment. In our experiment, rats were divided into 8 groups; some pretreated with metformin (Met, 200 mg/kg) (or) the AMPK inhibitor Compound C (CC) 14 days. On day 14, underwent transient forebrain global ischemia. Data indicated pretreatment of ischemic reduced working memory deficits...
Opioid addiction is one of the most crucial issues in world. abuse by parents makes children more prone to many psychological disorders such as drug addiction. Therefore, this study was carried out examine effect morphine exposure 10 days before gestation on and methamphetamine preference male offspring. Adult Wistar rats (male female) received orally for 21 were free days. Thereafter, they allowed mate with either a morphine-abstinent or drug-naive rat. The offspring tested three-bottle...
The main aim of this study was to assay the testicular H2S levels in varicocele rat model and then investigate protective effects NaHS on morphometric changes, sperm parameters, oxidative stress apoptosis markers rat's testis. D,L-propargylglycine (PAG) administrated show cystathionine γ-lyase enzyme (CSE) inhibition varicocele. Rats were assigned four groups: (a) Sham, (b) varicocele, (c) + PAG (d) NaHS. Animals group received 30 µmol/L drinking water for 56 days. In group, animals 19 mg/kg...