A5047062320- Synthesis and biological activity
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Protein Kinase Regulation and GTPase Signaling
- Diverse Scientific Research Studies
- Synthesis and Characterization of Heterocyclic Compounds
- vaccines and immunoinformatics approaches
- Fungal Plant Pathogen Control
- Cellular transport and secretion
- Cellular Mechanics and Interactions
- Crystallization and Solubility Studies
- Bone health and treatments
- SARS-CoV-2 and COVID-19 Research
- Enzyme Structure and Function
- X-ray Diffraction in Crystallography
Istanbul Medipol University
2019-2023
We report herein a new 1,2,3-triazole derivative, namely, 4-((1-(3,4-dichlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2-hydroxybenzaldehyde, which was synthesized by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The structure of the compound analyzed using Fourier transform infrared spectroscopy (FTIR), 1H NMR, 13C UV-vis, and elemental analyses. Moreover, X-ray crystallography studies demonstrated that adapted monoclinic crystal system with P21/c space group. dominant interactions...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for disease 2019 (COVID-19), one of the most challenging global pandemics modern era. Potential treatment strategies against COVID-19 are yet to be devised. It crucial that antivirals interfere with SARS-CoV-2 life cycle identified and developed. 3-Chymotrypsin-like protease (3CLpro) an attractive antiviral drug target SARS-CoV-2, coronaviruses in general, because its role processing viral polyproteins. Inhibitors...
Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread lethality rates COVID-19 have ignited studies that focus on development therapeutics for either treatment or prophylaxis purposes. In parallel, drug repurposing also come into prominence. Herein, we aimed at having holistic understanding conformational dynamical changes induced by an experimentally characterized inhibitor main protease (Mpro) which would...
Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and, unfortunately, within a short period time, emerged as pandemic. The spread and lethality rates COVID-19 have ignited studies that focus on development therapeutics for either treatment or prophylaxis purposes. In parallel, drug repurposing also come into prominence. this study, we aimed at having holistic understanding <br>conformational dynamical changes induced by an experimentally...
Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in cell. FTase has been demonstrated be highly expressed cancer and neurological diseases; hence considered as hot for therapeutic purposes. However, due nonspecific inhibition, there only one inhibitor that could translated into clinic. Importantly, it shown phosphorylation α-subunit increases activity enzyme certain...
Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and, unfortunately, within a short period time, emerged as pandemic. The spread and lethality rates COVID-19 have ignited studies that focus on development therapeutics for either treatment or prophylaxis purposes. In parallel, drug repurposing also come into prominence. this study, we aimed at having holistic understanding conformational dynamical changes induced by an experimentally...