A5087083814- Toxin Mechanisms and Immunotoxins
- Genetics and Neurodevelopmental Disorders
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Drug-Induced Hepatotoxicity and Protection
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Crystal structures of chemical compounds
- Organometallic Compounds Synthesis and Characterization
- Bipolar Disorder and Treatment
- Trace Elements in Health
- Acute Lymphoblastic Leukemia research
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Silymarin and Mushroom Poisoning
- Sirtuins and Resveratrol in Medicine
- Nigella sativa pharmacological applications
- BRCA gene mutations in cancer
- Genetic Syndromes and Imprinting
- Chemotherapy-induced organ toxicity mitigation
- Ion Channels and Receptors
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chronic Obstructive Pulmonary Disease (COPD) Research
Istanbul University
2024
Muğla University
2013-2023
Mersin Üniversitesi
2020
We report herein a new 1,2,3-triazole derivative, namely, 4-((1-(3,4-dichlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2-hydroxybenzaldehyde, which was synthesized by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The structure of the compound analyzed using Fourier transform infrared spectroscopy (FTIR), 1H NMR, 13C UV-vis, and elemental analyses. Moreover, X-ray crystallography studies demonstrated that adapted monoclinic crystal system with P21/c space group. dominant interactions...
In breast cancers, calcium signaling is a main cause of proliferation and apoptosis cancer cells. Although previous studies have implicated the transient receptor potential vanilloid 1 (TRPV1) cation channel, synergistic inhibition effects selenium (Se) cisplatin in suppression ongoing not yet been investigated MCF-7 This study investigates anticancer properties Se through TRPV1 channel activity cell line cultures when given alone or combination with cisplatin.The cells were divided into...
Diazinon (0,0-Diethyl 0-(1-6-methyl-2-isoprophyl 4 pyrimidinyl) phosphorothioate) (DI) is a very effective organophosphate pesticide, used widely in agriculture. Consequently, data on poisoning cases secondary to DI exposure are important. The may affect variety of tissues, including liver. Silibinin pharmacologically active constitute Silybum marianum, with documented antioxidant activity.The aim our study was evaluate both histopathologically and biochemically whether silibinin protective...
Chronic obstructive pulmonary disease (COPD) is an irreversible progressive chronic inflammatory that causes shortness of breath in consequence a decrease functions. The pathogenesis multifactorial. We have too little up-to-date information about the relation between COPD and genetics. In our study, with SIRT1 gene's mononucleotide polymorphisms (SNP) rs7895833, rs7069102 rs2273773 was analyzed through various laboratory data.One hundred patients from archive records Chest Diseases...
Diazinon (DI) is an organophosphate. Thymoquinone (TQ) produced from Nigella sativa. This study was a biochemical investigation of the protective properties TQ as supportive treatment in brain damage caused by diazinon. Rats were divided into four groups eight, follows: Group 1, control; group 2, DI; 3, DI + TQ; and 4, TQ. Groups 2 3 received DI. 4 In NO levels higher SOD lower compared to control group. than either or 2. DNA but difference between not significant. The results suggest that...
Background: The aim of this study was to analyze the role genetic variants two synaptic vesicle proteins (VAMP2 and Synaptotagmin XI) presynaptic plasma membrane (Syntaxin 1A SNAP-25) in patients with idiopathic generalized epilepsy (IGE). Method: Eighty-five IGE 93 healthy subjects were included study. We analyzed functional polymorphisms VAMP2, XI, Syntaxin SNAP-25 genes polymerase chain reaction restriction fragment length polymorphism methods. Results: In IGE, significant differences...
Background/Aims: SIRT1 gene overexpression is reportedly associated with cancer development, via the triggering of DNA repair impairment, and cell proliferation.The study aimed to investigate expression in patients gastric its correlations clinical pathological characteristics disease.Materials Methods: All (64 patients) who underwent biopsy were diagnosed adenocarcinoma signet ring carcinoma between January 2011 December 2013 enrolled study, benign control group (34 patients).The previously...
The protective effect of mistletoe extract (Helixor®, HLX) against methotrexate (MTX)-induced acute oxidative stress and nephrotoxicity in rats was evaluated by histological biochemical methods as well the comet assay.32 female Wistar albino were divided into 4 groups: control group, HLX group (5 mg/kg body weight (bw), days 1-10, intraperitoneally (i.p.)), MTX (10 bw, 7, 8, 9, i.p.), + i.p. 5 i.p.). At end experiment, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), nitric oxide...
PURPOSEAlthough attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen psychiatric disorders in childhood, its etiology and pathophysiology are not fully elucidated. The aim present study was to investigate association between ADHD RELN gene Turkish children.METHODDNA samples were harvested from 102 patients with 94 healthy controls. Three single-nucleotide polymorphisms reelin (rs1270519, rs362691, rs734147) genotyped using real-time polymerase chain...
Herein we report the green synthesis of silver nanoparticles (EcAgNPs) from water fraction (Ecs), obtained methanol extract Eucalyptus camaldulensis at room conditions. UV-vis, HR-TEM and SEM-EDS devices were used to characterize EcAgNPs. The UV-visible spectrum EcAgNPs showed surface plasmon resonance peak 420 nm. images that spherical with a diameter in range 3.7-29.6 Ag+ ions reduced Ago by phytochemicals without adding external reducing agent. presence biomolecules Ecs was investigated...
Malignant melanoma is a malignant neoplasia drives from melanocytes. melanoma, the most causing death, seen in third place at skin cancer. shows intrinsic resistance to chemotherapeutic agents and variability course of disease which are distinct features separating other solid tumors. These prevent development standardization non-surgical treatment models melanoma. Although there large number used metastatic it hasn’t been demonstrated survival advantage adjuvant with agents. Because...
Among genetic factors which contribute about 10-15 percent of male infertility, the most common causes infertility are Klinefelter’s Syndrome (KS) and Y chromosome microdeletions respectively. Most KS patients carry 47, XXY karyotype almost 15 them mosaic with variable phenotype. These abnormalities characterized by hypogonadism, azoospermia or oligospremia etc. A 41-year-old presented primary small hard testes upper limit FSH LH. Total azoospemia was showed on semen analysis. 47,XXY/46,XY...