Hatice Topal

ORCID: 0000-0003-3226-0205
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About
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Research Areas
  • Hemoglobinopathies and Related Disorders
  • Neonatal Health and Biochemistry
  • Inflammatory Biomarkers in Disease Prognosis
  • Autism Spectrum Disorder Research
  • Iron Metabolism and Disorders
  • Methemoglobinemia and Tumor Lysis Syndrome
  • Dental Research and COVID-19
  • Venous Thromboembolism Diagnosis and Management
  • Heme Oxygenase-1 and Carbon Monoxide
  • Advanced Chemical Sensor Technologies
  • Olfactory and Sensory Function Studies
  • Erythrocyte Function and Pathophysiology
  • Dental Health and Care Utilization
  • Poisoning and overdose treatments
  • Biochemical Analysis and Sensing Techniques
  • Blood groups and transfusion
  • Rabies epidemiology and control
  • Pediatric Hepatobiliary Diseases and Treatments
  • Nigella sativa pharmacological applications
  • Brucella: diagnosis, epidemiology, treatment
  • Infectious Diseases and Tuberculosis
  • Respiratory Support and Mechanisms
  • Pediatric health and respiratory diseases
  • Biomedical Research and Pathophysiology
  • Leptospirosis research and findings

Muğla University
2013-2024

Kocaeli Üniversitesi
2017

Cukurova University
2014

Altera (United States)
2014

Diazinon (0,0-Diethyl 0-(1-6-methyl-2-isoprophyl 4 pyrimidinyl) phosphorothioate) (DI) is a very effective organophosphate pesticide, used widely in agriculture. Consequently, data on poisoning cases secondary to DI exposure are important. The may affect variety of tissues, including liver. Silibinin pharmacologically active constitute Silybum marianum, with documented antioxidant activity.The aim our study was evaluate both histopathologically and biochemically whether silibinin protective...

10.5812/ircmj.17(4)2015.25310 article EN Iranian Red Crescent Medical Journal 2015-04-25

Methemoglobinemia is a disorder characterized by the presence of higher than normal level methemoglobin. Prilocaine which one oxidizing local anaesthetics widely used in many procedures. The first choice treatment complications due to use these methylene blue, while ascorbic acid alternative choice. side effects metilen blue restrict its usage some special conditions. Ascorbic good drug with limited experience methemoglobinemia. We present case methemoglobinemia treated successfully...

10.5812/ircmj.12718 article EN Iranian Red Crescent Medical Journal 2013-12-05

In this study, we aimed to detect the incidences of ototoxicity in patients with hemoglobinopathies taking deferoxamine (DFO), deferiprone, and deferasirox using National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) scale obtain more objective data.Fifty-five transfusion-dependent were evaluated study. The NCI CTCAE was used assess levels. average ferritin hemoglobin levels, type iron chelator, duration therapy all recorded.Ototoxicity observed 15 (31.9 %),...

10.5152/iao.2016.1852 article EN cc-by-nc The Journal of International Advanced Otology 2016-11-18

Diazinon (DI) is an organophosphate. Thymoquinone (TQ) produced from Nigella sativa. This study was a biochemical investigation of the protective properties TQ as supportive treatment in brain damage caused by diazinon. Rats were divided into four groups eight, follows: Group 1, control; group 2, DI; 3, DI + TQ; and 4, TQ. Groups 2 3 received DI. 4 In NO levels higher SOD lower compared to control group. than either or 2. DNA but difference between not significant. The results suggest that...

10.1080/09735070.2015.11905434 article EN Studies on Ethno-Medicine 2015-08-01

Thalassemia is an autosomal recessive inherited blood disorder. It prevalent in Mediterranean countries such as Sardinia, Greece, Cyprus, Turkey, Lebanon and also Southeast Asia. Our aim was to investigate the carrier prevalence of thalassemia other hemoglobinopathies adolescents who live Muğla Province, Turkey. We analyzed retrospectively surveys conducted at primary schools between 1997 2013. Complete count (CBC) high performance liquid chromatography (HPLC) were used screen for...

10.3109/03630269.2015.1046185 article EN Hemoglobin 2015-06-29

Background: This study aimed to assess myocardial performance index (MPI) and arterial elasticity indices in asymptomatic patients with beta-thalassemia major without known heart disease determine relationship between these parameters indicating iron load of body. Methods: The included 55 (median age: 20 years (10 - 48 years)) history 40 age- sex-matched healthy controls. MPI were determined by using standard two-dimensional Doppler echocardiography. Data analyzed SPSS for Windows version...

10.14740/jocmr2293w article EN Journal of Clinical Medicine Research 2015-01-01

Obstructive Sleep Apnea syndrome (OSA) is the most serious consequence of adenoid hypertrophy (AH) and it one common reasons nocturnal hypoxia in children. There some information about relationship between childhood OSA atherosclerosis or cardiac diseases. In this study, we evaluated between, neutrophil-lymphocyte ratio (NLR) AH which frequent cause leading children.Thus aimed to contribute subject preoperative postoperative NLR values patients undergoing adenoidectomy that there limited...

10.7860/jcdr/2016/16549.7360 article EN cc-by-nc-nd JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH 2016-01-01

Traditions are cultural heritages, habits, information, customs and behaviors that pass from generation to society society. Some traditions related infant care have conflicting practices such as swaddling. It is observed traditional been greatly reduced after training. On the other hand, it known applications which cause serious problems baby salting in our country still widely used many regions. important for pediatricians recognize of people regions where they work take role educators. In...

10.21601/ortadogutipdergisi.458292 article EN cc-by Ortadoğu Tıp Dergisi 2018-12-01

Abstract Background The aim of this study was to evaluate if the cord blood nucleated red cell (nRBC) levels can predict development hyperbilirubinemia in healthy neonates. Methods All newborn infants born after 35 or more weeks gestation at our hospital between January 2016 and April 2017 were included. nRBC counted umbilical samples. Neonates grouped into two groups based on presence absence neonatal jaundice. Results included overall 149 eligible infants. absolute count showed...

10.1515/labmed-2018-0065 article EN LaboratoriumsMedizin 2018-09-25

Ocular and ophthalmologic adverse effects may occur in patients with β-thalassemia major (BTM) treated regularly blood transfusions iron-chelating agents. We hypothesized that olfactory dysfunction be present this patient population. aimed to investigate BTM determine etiologic factors. A total of 43 were included the study. Forty-three subjects without nasal complaints, history facial trauma, or surgery as controls. All participants had endoscopy. The use agents by their duration recorded,...

10.1177/0145561317096010-1103 article EN Ear Nose & Throat Journal 2017-10-01

This study aims to examine leptin and ghrelin gene polymorphisms serum levels in children with autism spectrum disorder (ASD).

10.5152/pcp.2024.24827 article EN cc-by-nc Psychiatry and Clinical Psychopharmacology 2024-09-27

PURPOSEAlthough attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen psychiatric disorders in childhood, its etiology and pathophysiology are not fully elucidated. The aim present study was to investigate association between ADHD RELN gene Turkish children.METHODDNA samples were harvested from 102 patients with 94 healthy controls. Three single-nucleotide polymorphisms reelin (rs1270519, rs362691, rs734147) genotyped using real-time polymerase chain...

10.1080/24750573.2018.1478192 article EN cc-by Psychiatry and Clinical Psychopharmacology 2018-05-31

Ocular and ophthalmological adverse effects may be seen in β-thalassemia major (BTM) patients treated with regular blood transfusions iron-chelating agents. We hypothesized that olfactory dysfunction present this population. In study, we aimed to investigate BTM determine the etiological factors. A total of 43 were included study. Forty-three without any nasal complaints, history facial trauma, or surgery as controls. All participants had endoscopy. The agents used, their duration use, well...

10.1177/0145561319840079 article EN cc-by-nc Ear Nose & Throat Journal 2019-05-29

The purpose of this study is to achieve a vision for autistic children and their parents aimed at generating interest in ideas such as "Sanitas Per Aquam" (SPA), massage music therapy, which has begun have widespread use attract attention.

10.3831/kpi.2016.19.004 article EN cc-by-nc Journal of pharmacopuncture 2016-03-31

Aim: Dental problems in children are important health all over the world as well our country. In this study, we aimed to determine status of regular dental checkups and some sociodemographic characteristics 0-14 year old Turkey Material Method: The study was conducted using data from Turkish Statistical Institute Health Study Questionnaire 2014. Within scope a total 6946 individuals between years age were studied. Descriptive statistics taken first which for control aged 0-6 7-14. second...

10.21601/ortadogutipdergisi.347539 article EN Ortadoğu Tıp Dergisi 2017-12-06

Objective: With increasing frequency of autism spectrum disorder (ASD) in recent years, etiology has not yet been fully elucidated. Multiple hypotheses have proposed to explain including genetic, neurobiology-cal, psychosocial factors, environmental or iatrogenic causes. In this study, it was aimed evaluate the relationship between OSB and RELN gene polymorphism. Methods: The present study included 62 children with ASD diag-nosed by DSM-5 criteria, aged 3 12 years 64 age gender-matched...

10.5455/apd.292500 article EN Anatolian Journal of Psychiatry 2018-01-01

Introduction: Methamidophos is a pesticide.It widely used in agriculture.Safe storage of pesticides one the main issues agricultural societies.Here, we report four cases family members who unknowingly consumed pesticide that was stored water bottle.Emergency must be on alert for intoxication.Case Report: We from same with similar complaints admitted to emergency room.Case one: A 3-year-old boy suffering cough and shortness breath, diagnosed as bronchiolitis.A short time after...

10.5152/jaemcr.2014.342 article EN Journal of Academic Emergency Medicine Case Reports 2014-07-31

Kronik hastalıkların seyri sırasında insanlar hastalıklara çözüm için modern tıptan farklı arayışlar içine girmektedirler.Alternatif tıp dışında kökenleri olan yöntemler topluluğudur.Tamamlayıcı ise tıbbi tedavi ile birlikte, tedaviye ek olarak uygulanan ve bakım sistemidir.Tamamlayıcı alternatif (TAT) terimleri genellikle tek başlık altında toplanmak-tadır

10.12956/tjpd.2014.40 article TR Turkish Journal of Pediatric Disease 2014-03-21
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