A5059246439- Hematopoietic Stem Cell Transplantation
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
Johns Hopkins Medicine
2016
Johns Hopkins University
2016
Lower-intensity conditioning regimens for haploidentical blood or marrow transplantation (BMT) are safe and efficacious adult patients with hematologic malignancies. We report data pediatric/young high-risk malignancies (n = 40) treated nonmyeloablative BMT post-transplantation cyclophosphamide from 2003 to 2015. Patients received a preparative regimen of fludarabine, cyclophosphamide, total body irradiation. Post-transplantation immunosuppression consisted mycophenolate mofetil, tacrolimus....
Lower intensity conditioning regimens for haploidentical blood or marrow transplantation (BMT) have been demonstrated to be safe and efficacious adult patients with hematologic malignancies. We report the first data pediatric/young high-risk malignancies (n=40) enrolled on (n=28), treated according (n=12), IRB-approved clinical trials of nonmyeloablative BMT post-transplantation cyclophosphamide (PT/Cy) from 2003-2015. The majority (n=36) received a preparative regimen IV fludarabine (30...