A5049103250- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- MicroRNA in disease regulation
- Voice and Speech Disorders
- Otolaryngology and Infectious Diseases
- Epigenetics and DNA Methylation
- Foreign Body Medical Cases
- Analytical Methods in Pharmaceuticals
- Pesticide Residue Analysis and Safety
- Vascular Tumors and Angiosarcomas
- Dysphagia Assessment and Management
- Hippo pathway signaling and YAP/TAZ
- Fatigue and fracture mechanics
- Axon Guidance and Neuronal Signaling
- Fluorine in Organic Chemistry
- RNA modifications and cancer
- Obstructive Sleep Apnea Research
- Herbal Medicine Research Studies
- Autophagy in Disease and Therapy
- Wnt/β-catenin signaling in development and cancer
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
Zhengzhou People's Hospital
2004-2024
Jiangnan University
2024
Henan Provincial People's Hospital
2013-2023
Zhengzhou University
2016-2022
Abstract Cyclin D1 (CCND1) is a well‐known proliferation promoter that accelerates G1/S transition in cancer. However, the underlying mechanism by which CCND1 regulated still largely unknown. In this study, we identified novel circular RNA (circRNA) derived from (circ‐CCND1, hsa_circ_0023303) as key regulator for CCND1. circ‐CCND1 was found to be markedly up‐regulated laryngeal squamous cell carcinoma (LSCC) and closely associated with aggressive clinical features adverse prognosis....
The dysregulation of cytoplasmic collapsin response mediator protein 1 (CRMP1) has been reported in lung cancer, medulloblastoma and esophageal cancer. However, the role CRMP1 its regulatory mechanisms cancer remain unclear. In this study, we demonstrated that expression was downregulated tissues there were differences levels different cell lines. We found overexpression inhibited proliferation cells, whereas silencing promoted proliferation. performed an analysis potential microRNA (miRNA...
Laryngeal carcinoma is the second commonest head and neck globally.has been reported as a tumor suppressor in multiple malignancies including laryngeal squamous cell (LSCC).However, roles molecular mechanisms of miR-101 development LSCC have not fully elucidated.In present study, RT-qPCR assay was performed to detect expression enhancer zeste homolog 2 (EZH2) mRNA.Western blot conducted determine protein LC3-I, LC3-II, p62 EZH2.Cell proliferative capacity evaluated by MTS assay.The effect...
A reversed-phase ion pair chromatography method with liquid-liquid extraction analytical was developed and validated for the determination of antazoline hydrochloride in plasma excreta rat. The aim our study to characterize preclinical pharmacokinetics excretion profiles rats after intravenous injection at dose 10 mg/kg. Plasma samples were extracted ethyl acetate, phenacetin used as internal standard. result showed that is suitable quantification samples. Analysis accuracy (90.89-112.33%),...
Objective: Beclin1 was previously found to be downregulated in human laryngeal cancer (LC) tissues, and it results poor prognosis. This study aimed further confirm the antitumor effects of LC cell line Hep-2. Materials methods: Beclin 1 overexpressed Hep-2 cells using liposomal transfection confirmed reverse transcription polymerase chain reaction Western blotting. Then, proliferation apoptosis were determined control (untransfected), empty vector transfected, groups MTT flow cytometry...
Abstract The synthesis of two stereoisomers hydroindole derivatives was achieved through [3+2] annulations p ‐quinamines with nitroalkenes. Catalyst‐free or in the presence DMAP, annulation reactions were employed to produce target products containing four contiguous stereogenic centers. This method enables efficient construction multisubstituted and functionalized from readily accessible building blocks reagents. Furthermore, anti‐inflammatory activity some resulting hydroindoles evaluated,...
Objective:To explore the clinical significance of orofacial myofunctional therapy combined with muscle functional appliance in postoperative rehabilitation children OSA. Methods:Sixty were diagnosed as moderate-to-severe OSA AHI≥5 and underwent adenoid and/or tonsillar surgery. Children divided into two groups based on whether they willing to receive after Lateral cephalogram portable polysomnography performed, pediatric OSA-18 scale was filled under guidance medical staff. The treatment...
Objective:The aim of this study is to the effect 3-methyladenine (3-MA) on autophagy and apoptosis human laryngeal cancer Hep 2 cells induced by curcumin. Method:The proliferation Hep2 was observed MTT assay. The level detected AO acridine orange staining. Annexin VFITC/PI double staining used detect cells. expression LC3, Beclin1, Bcl-2 Bax protein were Western blot. Result:MTT assay showed that curcumin inhibited in a dose/time dependent manner. rate combined with 3-MA increased (P<0.05)....
本文报道了河南省人民医院耳鼻咽喉头颈外科收治的1例原发于咽后壁的巨大高分化脂肪肉瘤患者，采用全麻低温等离子手术切除联合术后化疗，术后随访11个月，未见复发。总结分析如下。.
Objective:To study the voice function effect of low temperature plasma radiofrequency ablation in treatment patients with laryngeal premalignant lesions. Method:Fifty cases lesions were treated ablation. All examined by electronic laryngoscopy and acoustic analysis(F0，Jitter，Shimmer，NNE，HNR) 2 weeks,1 month,3 months after surgery. Voice results compared a control group 50 normal adults for further analysis. Result:Fifty ablation.The result showed that 47 patients(94%)were successfully...
Objective To compare the effect of CO2 laser combined with radiofrequency ablation and conventional surgery on early glottic laryngeal carcinoma, explore advantages micro-surgery treatment cancer. Methods Ninety patients cancer admitted to People’s Hospital Zhengzhou University from October 2016 2018 were selected as study subjects. The divided into group A B, 45 cases in each group. Group was treated plasma therapy, while B traditional fissure surgery. length hospitalization,...