A5065395874- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Bacterial biofilms and quorum sensing
- Liver Disease Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Biochemical and Structural Characterization
- Helminth infection and control
- Pancreatic function and diabetes
- Ubiquitin and proteasome pathways
- Parasite Biology and Host Interactions
- Diabetes Treatment and Management
- Cancer, Hypoxia, and Metabolism
- Parasites and Host Interactions
- Metabolism, Diabetes, and Cancer
- Streptococcal Infections and Treatments
University of Pittsburgh
2022-2024
University of the District of Columbia
2021
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies that includes steatosis, steatohepatitis (NASH) and fibrosis is strongly associated with insulin resistance type 2 diabetes. Changes in mitochondrial function are implicated the pathogenesis NAFLD, particularly transition from steatosis to NASH. Mitophagy quality control mechanism allows for selective removal damaged mitochondria cell via autophagy pathway. While past work demonstrated negative association between...
Beyond glycemic control, SGLT2 inhibitors (SGLT2is) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. activity is also important for regulation endosomal pH, but the SGLT2i endocytosis are unknown. We used a highly differentiated cell culture model proximal tubule (PT) cells determine direct Na
The production and release of cytolytic toxins is a critical aspect for the pathogenicity many bacterial pathogens. In this study, we demonstrate role wall teichoic acids, molecules that are anchored to peptidoglycan cell wall, in from S. aureus cells into extracellular environment.
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies that includes steatosis, steatohepatitis (NASH) and fibrosis is strongly associated with insulin resistance type 2 diabetes. Changes in mitochondrial function are implicated the pathogenesis NAFLD, particularly transition from steatosis to NASH. Mitophagy quality control mechanism allows for selective removal damaged mitochondria cell via autophagy pathway. While past work demonstrated negative association between...
Background Schistosomiasis remains widespread in many regions despite efforts at its elimination. By examining changes the transcriptome host-pathogen interface snail Biomphalaria glabrata and blood fluke Schistosoma mansoni , we previously demonstrated that an early stress response juvenile snails, manifested by induction of heat shock protein 70 (Hsp 70) Hsp 90 reverse transcriptase (RT) domain B . non-LTR- retrotransposon, nimbus were critical for susceptibility to S Subsequently, BS-90...
Abstract A major feature of the pathogenicity Staphylococcus aureus is its ability to secrete cytolytic toxins. This process involves translocation toxins from cytoplasm, through bacterial membrane and cell wall external environment. The their movement relatively well defined, involving both general toxin-specific secretory systems. Movement was considered involve passive diffusion proteins porous structures, however, recent work suggests that this more complex, here we demonstrate a role...
Mitochondria regulate several cellular and metabolic processes, necessitating cells to employ highly evolved quality control mechanisms remove damaged mitochondria through a selective form of autophagy called mitophagy. Mitophagy is mitochondrial pathway, mediated in part by the ubiquitination outer membrane (OMM) proteins. USP30 an OMM deubiquitinase that regulates mitophagy degrading ubiquitin, thus inhibiting Hepatic reduced obese fatty liver associated with dysfunction. Whether...