A5101895057- Cutaneous lymphoproliferative disorders research
- Chemotherapy-related skin toxicity
- Autoimmune and Inflammatory Disorders
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Acute Ischemic Stroke Management
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Higher Education Learning Practices
- Blood Coagulation and Thrombosis Mechanisms
- Text Readability and Simplification
- Autophagy in Disease and Therapy
- Vascular Tumors and Angiosarcomas
- Aerospace and Aviation Technology
- Human Resource Development and Performance Evaluation
- Health Literacy and Information Accessibility
- Advertising and Communication Studies
- Endoplasmic Reticulum Stress and Disease
- Advanced Aircraft Design and Technologies
- Balance, Gait, and Falls Prevention
- Psoriasis: Treatment and Pathogenesis
- PI3K/AKT/mTOR signaling in cancer
- Viral-associated cancers and disorders
- Substance Abuse Treatment and Outcomes
University of Pittsburgh
2022-2025
Fate Therapeutics (United States)
2022
Chapman University
2020
Sidney Kimmel Cancer Center
2005-2019
Roche (United States)
2002-2011
Thomas Jefferson University
2005-2007
Abstract Collagenases are involved in cartilage matrix resorption. Using bovine fetal chondrocytes isolated from physeal cartilages and separated into a distinct prehypertrophic subpopulation, we show that serum-free culture they elaborate an extracellular differentiate hypertrophic chondrocytes. This is characterized by expression of type X collagen the transcription factor Cbfa1 increased incorporation of45Ca2+ matrix, which associated with calcification. Collagenase activity, attributable...
The development of a new series p38α inhibitors resulted in the identification two clinical candidates, one which was advanced into phase 2 study for rheumatoid arthritis. original lead, an lck inhibitor that also potently inhibited p38α, screening hit from our kinase library. This manuscript describes optimization lead to p38-selective examples with good pharmacokinetic properties.
Abstract Reinforcement learning studies propose that decision-making is guided by a tradeoff between computationally cheaper model-free (habitual) control and costly model-based (goal-directed) control. Greater typically used under highly rewarding conditions to minimize risk maximize gain. Although prior have shown impairments in sensitivity reward value individuals with frequent alcohol use, it unclear how these arbitrate based on the magnitude of incentives. In this study, 81 (47 Alcohol...
Inpatient teledermatology (ITD) is a growing telemedicine modality aimed at addressing the shortage of dermatologists in hospitals, particularly for management complex skin disorders. Generalized pustular psoriasis (GPP) rare and potentially life-threatening condition characterized by widespread sterile pustules systemic inflammation. Despite advances targeted therapies, treatment often limited to traditional agents such as cyclosporine infliximab, due restrictions formulary access insurance...
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies that includes steatosis, steatohepatitis (NASH) and fibrosis is strongly associated with insulin resistance type 2 diabetes. Changes in mitochondrial function are implicated the pathogenesis NAFLD, particularly transition from steatosis to NASH. Mitophagy quality control mechanism allows for selective removal damaged mitochondria cell via autophagy pathway. While past work demonstrated negative association between...
Background:Early detection of melanoma improves survival; however, patients face long wait times to receive dermatology care. Teledermatology (TD) is a promising tool optimize access care and has shown promise for the identification malignancies but not been well studied melanoma. We evaluated utility TD as triage allow high-risk lesions concern be seen more expeditiously. Methods:Patient sociodemographic factors histological characteristics 836 melanomas biopsied between March 2020 November...
Generalized pustular psoriasis (GPP) is a multisystem disease with potentially life-threatening adverse effects. As patients increasingly seek health information online, and as the landscape for GPP changes, quality of online (OHI) becomes progressively more important. This paper first its kind to examine quality, comprehensiveness readability GPP. Similar pre-existing studies evaluating OHI, this examines 5 key search terms GPP- 3 medical 2 laymen. For each term, results were evaluated...
Hydroxychloroquine (HCQ) has been reported to cause pustular drug eruptions such as acute generalized exanthematous pustulosis (AGEP) and putular psoriasis (PP). Clinical differentitation of these entities is often difficult. This case emphasizes characteritics AGEP PP well the need for clinicans proactively follow-up patients monitor more aggressive outcome PP.
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<h3>Introduction/purpose</h3> Although pediatric stroke is far less common than adult acute ischemic stroke, the incidence still as high 13/100,000. In patients with moderate to severe strokes, based on a NIH scale greater 17 or an basilar artery occlusion, natural history of disease extremely poor despite increasingly earlier identification in setting more complex treatment for congenital heart disease. According most recent 2008 American Heart Association guidelines, TPA thrombectomy...
<h3>Background and objective</h3> The first pass effect (FPE) has become a novel measure for neurointerventionalists, achieving complete recanalization with single thrombectomy device pass, which been shown to be associated higher rates of good clinical outcomes. We describe expand the FPE one large US post-marketing registry (TRACK, Trevo Stent-Retriever Acute Stroke) elucidate outcome. <h3>Methods</h3> TRACK was core-laboratory adjudicated multicenter 634 patients from 23 centers aimed...
Chen, Jeffrey BA*; Vaughan, Victoria Claire MD†; Matisko, Morgan PA-C‡; English, Joseph C III MD‡; Kazlouskaya, Viktoryia MD, PhD† Author Information
Chen, Jeffrey BA*; Vaughan, V. Claire MD†; Matisko, Morgan PA-C‡; English, Joseph C. III MD‡; Kazlouskaya, Viktoryia MD, PhD† Author Information