A5027343507- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Catalytic Alkyne Reactions
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Crystallography and molecular interactions
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Chemical Reactions and Isotopes
- Fluorine in Organic Chemistry
- Oxidative Organic Chemistry Reactions
- Advanced biosensing and bioanalysis techniques
- Sulfur Compounds in Biology
- RNA Interference and Gene Delivery
- Bone health and treatments
- Bone Tissue Engineering Materials
- Synthesis and Reactions of Organic Compounds
- Epigenetics and DNA Methylation
- Biopolymer Synthesis and Applications
- Traditional and Medicinal Uses of Annonaceae
- Cancer Treatment and Pharmacology
- Asymmetric Hydrogenation and Catalysis
University of Missouri
2012-2024
Columbia College - Missouri
2017
South College
2017
Peptide amphiphile micelles (PAMs) are attractive vehicles for the delivery of a variety therapeutic and prophylactic peptides. However, key limitation PAMs is their lack preferential targeting ability. In this paper, we describe our design PAM system that incorporates DNA oligonucleotide (antitail amphiphile-AA) to form A/PAMs. A cell-targeting aptamer with 3' extension sequence (tail) complementary AA annealed surface aptamer-displaying (Aptamer~A/PAMs). Aptamer~A/PAMs small, anionic,...
Intramolecular redox reaction: Heating N-alkyl, N-allyl-, and N-benzyl-substituted S-alkenyl sulfoximines under appropriate conditions results in the formation of NH-S-alkyl sulfoximines. The intramolecular reaction involves a hydride transfer that occurs by 6-endo-trig process. intermediates can also give access to four- six-membered heterocyclic rings new class chiral dienes. Detailed facts importance specialist readers are published as "Supporting Information". Such documents...
Treatment of α-hydroxy allenic sulfones with 10 mol % silver fluoride in acetonitrile at ambient temperature furnished the corresponding 3-tosyl 2,5-dihydrofurans excellent yields via a 5-endo-trig cyclization. The starting were prepared by lithiation and trapping carbonyl compounds.
Abstract Herein, attempted oxidation of selected allenols with PCC affording α′‐hydroxydienones rather than simple products is described. The formation the observed rationalized via a series sigmatropic shifts, followed by hydrolysis.
Abstract The scope of the [2,3]‐sigmatropic rearrangement propargylic sulfinates to allenic sulfones by silver catalysis was expanded. A series new sulfinate esters generated from a variety aromatic and heteroaromatic sulfonyl chlorides their is reported. In addition, synthesis containing electron‐withdrawing benzenesulfonyl magnified image
Treatment of allenyl sulfonamides with catalytic amounts silver fluoride in acetonitrile at reflux afforded the corresponding 3-sulfonyl-3-pyrrolines excellent yields by intramolecular hydroamination via a 5-endo-trig cyclization. The starting were prepared lithiation allenic sulfones and trapping various N-sulfonylimines.
A 3-phenylsulfanyl-substituted allylic alcohol and an ester thereof were treated with Brønsted acids or a gold catalyst, respectively, to generate vinylthionium ions. These species react dienes, primarily substituted furans, give products of either (4 + 3)-cycloaddition Friedel-Crafts alkylation. The results are rationalized on the basis stepwise mechanism in which relative rates ring closure versus proton loss intermediate σ-complex determine course reaction.
Though crucial for natural bone healing, local calcium ion (Ca
Treatment of readily available α'-hydroxyenones with a catalytic amount strong acid in refluxing toluene affords the corresponding dihydrofuran-3(2H)-ones excellent yields via formal 5-endo-trig cyclization.
Intramolekulare Redoxreaktion: Das Erhitzen von N-Alkyl, N-Allyl- und N-Benzyl-substituierten S-Alkenylsulfoximinen führt unter bestimmten Bedingungen zur Bildung NH-S-Alkylsulfoximinen. Die intramolekulare Redoxreaktion umfasst einen Hydridtransfer, der durch 6-endo-trig-Prozess erfolgt. Intermediate Reaktion können außerdem Zugang zu vier- sechsgliedrigen heterocyclischen Ringen sowie einer neuen Klasse chiraler Diene eröffnen. Detailed facts of importance to specialist readers are...
Abstract Poly(amino acid)s are a diverse and capable class of polymers with significant potential for utilization in wide variety drug delivery applications. A sub-class these biomaterials known as lipidated poly(amino (LPAAs) amphiphiles composed both hydrophobic hydrophilic domains yielding interesting physical properties. In this article, we describe our efforts developing novel lysine valine containing LPAAs synthesized via hexadecylamine initiated N-carboxyanhydride ring-opening...
Propargylic sulfinates can be successfully deprotonated at the acetylenic carbon with lithium hexamethyldisilazide. The resulting anions add to aldehydes and ketones. Treatment of these adducts a silver cation results in both 2,3‐sigmatropic shift cyclization allene afford 2,5‐dihydrofurans excellent yields.
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Catalytic Generation of Vinylthionium Ions. (4 + 3)-Cycloadditions and Friedel–Crafts AlkylationsMichael Topinka, Rama Rao Tata, Michael Harmata*Cite this: Org. Lett. 2014, 16, 20, 5508Publication Date (Web):September 30, 2014Publication History Received18 September 2014Published online30 inissue 17 October...
Abstract Treatment of ester (I) and alcohol (IV) with the gold catalyst or TFA results in formation vinylthionium ions.
Abstract Acid‐catalyzed formal 5‐endo‐trig cyclization of α′‐hydroxy α‐enones affords dihydrofuranones in excellent yields.
Abstract Oxidation of readily prepared allenols with PCC affords α′‐hydroxydienones rather than simple oxidation products.
The authors of this communication wish to add the following sentence their acknowledgement: “V.G. acknowledges support DOE grant DE-SC0002040.”
Ein Hydridtransfer der über einen 6-endo-trig-Prozess verläuft, initiiert eine intramolekulare Redoxreaktion. In ihrer Zuschrift auf S. 7122 ff. zeigen M. Harmata et al., dass das Erhitzen von N-Alkyl-, N-Allyl- und N-Benzyl-substituierten S-Alkenylsulfoximinen unter bestimmten Bedingungen zur Bildung NH-S-Alkylsulfoximinen führt. Die Intermediate Reaktion können außerdem Zugang zu vier- sechsgliedrigen heterocyclischen Ringen sowie einer neuen Klasse chiraler Diene schaffen.
Die Autoren dieser Zuschrift möchten ihrer Danksagung den folgenden Satz anfügen: “V.G. acknowledges the support of DOE grant DE-SC0002040.”