A5086668813- Blood properties and coagulation
- Erythrocyte Function and Pathophysiology
- Synthesis and bioactivity of alkaloids
- Berberine and alkaloids research
- Synthesis and Biological Evaluation
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Blood groups and transfusion
- Heart Failure Treatment and Management
- Erythropoietin and Anemia Treatment
- Nanoparticle-Based Drug Delivery
- Chemical synthesis and alkaloids
- Metabolism and Genetic Disorders
- Vitamin C and Antioxidants Research
- Toxin Mechanisms and Immunotoxins
- Hydrogen's biological and therapeutic effects
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacogenetics and Drug Metabolism
- Complementary and Alternative Medicine Studies
- Pancreatic function and diabetes
- Drug-Induced Hepatotoxicity and Protection
- Electrospun Nanofibers in Biomedical Applications
- Glutathione Transferases and Polymorphisms
- Dendrimers and Hyperbranched Polymers
University of Jordan
2009-2024
Aims: Micellar systems have the advantage of being easily prepared, cheap, and readily loadable with bioactive molecular cargo. However, their fundamental pitfall is poor stability, particularly under dilution conditions. We propose to use simple quaternary ammonium surfactants, namely, hexadecylamine (HDA) hexadecylpyridinium (HDAP), together tripolyphosphate (TPP) anion, generate ionotropically stabilized micelles capable drug delivery into cancer cells. Methods: optimized mixed HDA/HDAP...
This study was designed to load different antibodies (Abs) and a fluorescent dye onto the red blood cell (RBC) surface. We have used fluorescein isothiocyanate (FITC)-conjugate anti-human Ab, CD22-PE (B-cell marker-phycoerythrin Ab), 4',6-diamidino-2-phenylindole (DAPI) for insertion over RBC In first step, conjugation experiments were performed: in dimethyl sulfoxide (DMSO), RBCs conserved modified by succinic anhydride create an additional -COOH group, then activated with...
Introduction: This study explored d-ribose pharmacokinetics after intravenous (IV) and oral administration to healthy rabbits. Materials methods: D-ribose was administered once as 420 mg/kg (N=4) or 840 (N=6) dose intravenously, an of (N=3) (N=3). Serum obtained at various time points, up 210 minutes administration. Urine also collected IV Pharmacokinetic parameters were determined from drug concentration–time data using Kinetica software. Results: The findings showed that follows a...
Peganum harmala L., Zygophyllaceae popularly known as Wild Syrian rue, a well-known plant in folk medicine for many pharmacological uses including antispasmodic activity. Chemical composition of the showed that most important constituents this are betacarboline alkaloids such harmalol, harmaline, and harmine. In work, we aimed to evaluate effects these three major on induced rat ileum contractions, by acetylcholine, BaCl2 KCl. Of alkaloids, harmalol harmaline produced concentration-dependent...
Background and Objective: Although Bongardia chrysogonum L. (family Berberidaceae) has been used in many countries traditional medicine to treat gastrointestinal tract disorders, scientific evidence for this treatment is lacking. The present study was carried out assess the antimicrobial activity evaluate antispasmodic potential of B. tuber extract. Materials Methods: Extracts were also evaluated against Bacillus subtilis, Staphylococcus aureus, S. epidermidis, Escherichia coli Pseudomonas...
Backgrounds: Various physiological functions and reaction cascades, as well disease progression in the living systems, are controlled by activity of specific proteolytic enzymes. We conducted study to evaluate protease assessing peptide fragments from either conserved or labeled red blood cells (RBCs) with aminofluorescein (AF) media. Methods: RBCs were incubated media containing trypsin. Subsequently, concentration media, resulted digestion trypsin cells, was estimated...
Genetic susceptibility to lung cancer is the subject of extensive research. We investigated whether polymorphisms in microsomal epoxide hydrolase (EPHX1) gene linked Jordanian patients.
Background: Hubble-Bubble smoking is a common practice and spreading fast among young adults even in western countries. People think it less toxic than cigarette smoking.
 Aim: The aim of this study was to investigate the levels oxidative stress markers antioxidants blood (smokers compared controls as sign toxicity, since disease process caused by abnormal antioxidant capacity.
 Methods: Blood samples were collected authorized personnel from recruited healthy volunteers (28...
Abstract Red blood cells (RBCs) are attractive tools for surface modification to adhere specifically molecules, cellular fragments (e.g., microvesicles), or whole potential use in bioanalytical assays as a delivery vehicle targeted therapy. Within this study, we have loaded RBCs with fluorochrome‐conjugated antibodies (Ab) against CD45 and CD22 leukocyte markers evaluated the conjugation process by microscopy. We assessed application of generated from conjugated targeting Cyto‐Trol control...
We aim to evaluate the potential application of amine reactive fluorogenic reagents for estimating enzymatic proteolysis.Proteolytic enzymes play important roles in regulating many physiological processes living organisms.Assessment protein degradation by using assay techniques.We have assayed samples at start and after 30-60 minutes incubation with trypsin Chromeo P503 (Py 1 pyrylium compound) CBQCA (3-(4-carboxybenzoyl) quinoline-2-carboxaldehyde) as NanoOrange non-amine dye.All BSA...
Purpose: To investigate the contractile responses of vascular smooth muscle cells (VSMCs) to spasmogens after incubation with harmaline, harmine, and harmalol, which are alkaloids obtained from Peganum harmala L., a member Zygophyllaceae family.
 Methods: Contractile VSMCs norepinephrine (NE; 1 µmol/L) potassium chloride (KCl; 60 mmol/L) were recorded in rat aortic ring preparations pre-incubated 0.5, 1, 5 10 µmol/L each alkaloid for 15 min. Responses expressed as mean values...