Abstract BACKGROUND. Mantle cell lymphoma (MCL) is a distinct subtype of B‐cell non‐Hodgkin's lymphoma. To the authors' knowledge, little known regarding its incidence patterns and associated factors. The purpose current study was to examine MCL over period 13 years identify factors with patterns. METHODS. Patients diagnosed between 1992 2004 were identified from Surveillance, Epidemiology, End Results (SEER) Tumor registries. SEER*Stat statistical software used for analysis. RESULTS. Of...

Abstract BACKGROUND: Waldenstrom macroglobulinemia (WM) is a non‐Hodgkin lymphoma (NHL) subtype. Little known about the incidence and trends for this disease in United States. METHODS: Twenty‐year data from Surveillance, Epidemiology, End Results (SEER) program were used study. SEER*Stat was analysis. RESULTS: Of 95,797 cases of NHL diagnosed between 1988 2007 9 SEER registries, 1835 (1.9%) new WM. Median age at diagnosis WM 73 years. The overall annual age‐adjusted 0.38 per 100,000 persons...

Abstract BACKGROUND: With the introduction of all‐ trans retinoic acid and arsenic trioxide, management acute promyelocytic leukemia (APL) has changed dramatically. We performed a population‐based study APL in United States to determine its incidence relative survival (RS) during 34‐year period. METHODS: identified 1397 patients diagnosed with between 1975 2008 Surveillance, Epidemiology, End Results database. Patients were categorized into 4 age groups 3 calendar periods. As comparison, we...

Background. The updated 2010 Infectious Diseases Society of America guidelines recommended 3 first-line therapies for uncomplicated cystitis: nitrofurantoin, trimethoprim-sulfamethoxazole (TMP-SMX), and fosfomycin, while fluoroquinolones (FQs) remained as second-line agents. We assessed guideline concordance antibiotic choice treatment duration after introduction the studied patient characteristics associated with prescribing specific antibiotics duration. Methods. used Epic Clarity database...

Objective: To investigate the clinical efficacy of sintilimab injection and chemotherapy as neoadjuvant therapy for stage IB–IIIB non-small cell lung cancer(NSCLC), evaluate its safety. Methods: A retrospective analysis was conducted on data patients with NSCLC who underwent treatment before surgery at Affiliated Hospital Hebei University, between June 2021 to August 2023. Eighty were divided into an observation group(n = 40) a control according their regimens. The group administered...

AbstractThe epidemiology of splenic marginal zone lymphoma (SMZL) in the United States has not been addressed. Eight years data (2001–2008) from 17 registries Surveillance, Epidemiology and End Results (SEER) program were used for this study. Of 116 411 cases non-Hodgkin (NHL) registries, 763 (0.6%) SMZL. The overall annual age-adjusted incidence was 0.13 per 100 000 persons year. percent change 4.81% (p < 0.05), significantly increasing trends found patients who white, male or aged 70 older...

Abstract Background Ethnicity and insurance status have been shown to impact odds of presenting with metastatic cancer, however, the interaction these two predictors is not well understood. We evaluate difference in disease minorities compared white patients despite access same across three common cancer types. Methods Using National Cancer Database, a multilevel logistic regression model that estimated was fit, adjusting for covariates including year diagnosis, ethnicity, insurance, income,...

Ligand modification and receptor site-directed mutagenesis were used to examine binding of the competitive antagonist, d-tubocurarine (dTC), muscle-type nicotinic acetylcholine (AChR). By using various dTC analogs, we measured interactions specific functional groups with amino acid positions in AChR gamma-subunit. Because data for mutations at residue gammaTyr(117) most consistent direct interaction dTC, focused on that residue. Double mutant thermodynamic cycle analysis showed apparent both...

Reducing inappropriate antibiotic prescribing is currently a global health priority. Current guidelines recommend against treatment for acute uncomplicated bronchitis. We studied patterns bronchitis and identified predictors of prescribing. used the Epic Clarity database (electronic medical record system) to identify all adult patients with in family medicine clinics from 2011 2016. excluded factors that could justify use, such as suspected pneumonia, COPD or immunocompromising conditions....

Public health prevention efforts have led to overall reductions in mortality from screening-preventable cancers. We explored cancer screening behaviors of smokers, former and nonsmokers among patients large primary care practices discover the relationship between smoking status previous adherence United States Preventive Services Task Force breast, cervical, colorectal recommendations. Our descriptive study electronic medical record data included 6,029 established patients. Multi-predictor...

Abstract Background Cancer among infants (&lt;1 year old) has unique epidemiologic, clinical, and genetic characteristics compared with cancer in older children. Nonetheless, data on secular trends infant incidence survival the United States is sparse. Methods Population‐based from nine areas of Surveillance Epidemiology End Results (SEER) were used to estimate incidence, average annual percentage change (APC) for trends, malignant neoplasm 1975 2014. Data stratified by gender, race,...

<h3>Objective</h3> To investigate the incidence and trends in colorectal cancer (CRC) among Asian American populations United States. <h3>Methods</h3> CRC data from 1994 through 2013 were obtained 13 Surveillance, Epidemiology, End Results registries. SEER*Stat IBM SPSS Statistics used. <h3>Results</h3> The age-adjusted of Americans decreased 45.6 per 100,000 to 33.0 2013, with annual percent change being −1.8% (<i>P</i>&lt;0.05). incidences higher for men, elderly (aged 60 years or older),...

<h3>Objective</h3> This quality improvement project evaluated the impact of a point-of-care (POC) HbA1c stat lab intervention and nurse-assisted expanded visit implemented among patients with uncontrolled type 2 diabetes (T2D) at community health center in Houston, TX. <h3>Methods</h3> was before-and-after POC adult who received primary care services between 1 July 2014 31 December (baseline visit) had least one 3-month follow-up visit. <h3>Results</h3> Three hundred eighty-seven were...

To investigate the effect of stat3 phosphorylation and p53 expression on human epidermal non-melanoma cutaneous tumours.Immunohistochemistry technique was employed to measure p-stat3 protein in skin tissue from 30 cases squamous cell carcinoma (SCC), 20 basal (BCC), seborrhoeic keratosis (SK) normal subjects.(1) abnormally increased SCC BCC as compared with SK. Expression also significantly higher than that BCC. (2) poorly-differentiated cancers well-differentiated SCC. The positive rate...

Objective To increase the statistic power to estimate radiation-induced cancer risk on basis of analysis 1999-2002 follow-up data from high background radiation areas (HBRA), in combination with those period 1979-1998, and further at low dose after adjustment individual smoking factor. Methods Cohort studies were conducted mortality for residents both HBRA control area (CA), made phases. The present study was first focused collection during 1999-2002, preliminary risks mortality. And...

The goal of this project is to improve the influenza immunization rate eligible asthmatics admitted Pediatric Hospital Medicine (PHM) service 80% by February 2015. Asthma patients were identified via ICD-9 codes, and charts manually reviewed determine status. Metrics included:

Adherence to 2011 Infectious Diseases Society of America (IDSA) guidelines for urinary tract infections (UTIs) remains low in primary care. Fluoroquinolones are commonly prescribed treat uncomplicated cystitis, and most antibiotic prescriptions have durations that exceed current recommendations. We performed a difference-in-differences study assess the effectiveness stewardship intervention family medicine clinic at an academic outpatient center from August 2016 March 2019. During our...

Background: Cancer among infants (<1 year old) has unique epidemiologic, clinical and genetic characteristics compared with cancer in older children. Nonetheless, data on secular trends infant incidence survival the US is sparse. Methods: Population-based from Surveillance Epidemiology End Results (SEER 9) was used to estimate incidence, average annual percentage change (APC) for of malignant neoplasm 1975-2014. Data were stratified by gender, race, registry type. Results: There 3,437 new...