A5035232187- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Pancreatic and Hepatic Oncology Research
- Hemoglobin structure and function
- Bacteriophages and microbial interactions
- Protein Interaction Studies and Fluorescence Analysis
- Bacterial Genetics and Biotechnology
- Advanced Biosensing Techniques and Applications
- 3D Printing in Biomedical Research
- Genomics and Phylogenetic Studies
- Cell Image Analysis Techniques
- Genetic factors in colorectal cancer
- Spectroscopy and Quantum Chemical Studies
Translational Research in Oncology
2017
Medicon Village
2015-2016
Lund University
2013-2016
McMaster University
2009-2013
Exploration of new strategies for the prevention breast cancer metastasis is justifiably at center clinical attention. In this study, we combined a computational biology approach with mechanism-based preclinical trials to identify inhibitors activin-like receptor kinase (ALK) 1 as effective agents blocking angiogenesis and in cancer. Pharmacologic targeting ALK1 provided long-term therapeutic benefit mouse models mammary carcinoma, accompanied by strikingly reduced metastatic colonization...
The entrapment of bacterial cells within inorganic silica materials was reported almost 20 years ago. However, all studies to date have shown that these entrapped are unable divide and thus should be expected reduced promoter activity. In view the importance bacteria as model systems for both fundamental applied biological studies, it is crucial immobilized retain solutionlike properties, including ability display normal Herein we report on a method immobilize low-density silica-based...
We report the fabrication of three-dimensional living-cell microarrays via pin-printing soft sol–gel-derived silica materials containing bacterial cells. Bacterial cells entrapped in silica–glycerol microarray spots can express reporter genes and produce strong fluorescence signals. The signals responded to presence concentration inducers or repressors as expected, indicating that remained metabolically active. Microscopic imaging individual at different culture times suggests grow divide,...
Angiogenesis occurs early in tumor development, sustains primary growth and provides a route for metastatic escape. The TGF-β family receptors modulate angiogenesis via endothelial-cell specific pathways. Here we investigate the interaction of two such receptors, ALK1 endoglin, pancreatic neuroendocrine tumors (PanNET). Independently, endoglin deficiencies exhibited genetically divergent phenotypes, while both highly correlate to an endothelial metagene human mouse PanNETs. A concurrent...
<p>Endothelial genes co-expressed with ACVRL1 in the clinical data sets.</p>
<p>Legends for Supplemental Figures S1-S3.</p>
<p>Relating ACVRL1 to prototypical endothelial gene expression makes the association with risk of distant disease coherent across treatment groups.</p>
<p>The therapeutic benefit of ALK1-Fc is due to on-target effects on ALK1 signaling.</p>
<p>ALK1 expression is endothelial cell-exclusive in mammary tumors from MMTV-PyMT mice.</p>
<p>The therapeutic benefit of ALK1-Fc is due to on-target effects on ALK1 signaling.</p>
<p>Endothelial genes co-expressed with ACVRL1 in the clinical data sets.</p>
<p>Legends for Supplemental Figures S1-S3.</p>
<p>ALK1 expression is endothelial cell-exclusive in mammary tumors from MMTV-PyMT mice.</p>
<p>Relating ACVRL1 to prototypical endothelial gene expression makes the association with risk of distant disease coherent across treatment groups.</p>
<div>Abstract<p>Exploration of new strategies for the prevention breast cancer metastasis is justifiably at center clinical attention. In this study, we combined a computational biology approach with mechanism-based preclinical trials to identify inhibitors activin-like receptor kinase (ALK) 1 as effective agents blocking angiogenesis and in cancer. Pharmacologic targeting ALK1 provided long-term therapeutic benefit mouse models mammary carcinoma, accompanied by strikingly...
<div>Abstract<p>Exploration of new strategies for the prevention breast cancer metastasis is justifiably at center clinical attention. In this study, we combined a computational biology approach with mechanism-based preclinical trials to identify inhibitors activin-like receptor kinase (ALK) 1 as effective agents blocking angiogenesis and in cancer. Pharmacologic targeting ALK1 provided long-term therapeutic benefit mouse models mammary carcinoma, accompanied by strikingly...