A5036846005- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Asymmetric Hydrogenation and Catalysis
- Coordination Chemistry and Organometallics
- Magnetism in coordination complexes
- Carbon dioxide utilization in catalysis
- Organophosphorus compounds synthesis
- Library Science and Administration
- Hydrogen Storage and Materials
- Metal complexes synthesis and properties
- Catalysis for Biomass Conversion
- Organoboron and organosilicon chemistry
- Catalytic C–H Functionalization Methods
- Catalysts for Methane Reforming
- Inorganic Chemistry and Materials
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Inorganic and Organometallic Chemistry
- Public-Private Partnership Projects
- Synthesis and biological activity
- Synthesis and Reactivity of Heterocycles
- Ferrocene Chemistry and Applications
University of Nottingham
2018-2024
GlaxoSmithKline (United Kingdom)
2024
University of St Andrews
2014-2023
OpenEdition Center
2021
Park University
2019-2020
St. Andrews University
2015-2016
University of Cambridge
2012
Selly Oak Hospital
1991-1999
In this Perspective, we will highlight selected examples of transition metal complexes with low coordination numbers whose high reactivity has been exploited in catalysis and the activation small molecules featuring strong bonds (N<sub>2</sub>, CO<sub>2</sub>, CO).
Treatment options for the management of breast cancer are still inadequate. This inadequacy is attributed to lack effective targeted medications, often resulting in recurrence metastatic disorders. Cumulative evidence suggests that epidermal growth factor receptor (EGFR-TK) and cyclin-dependent kinases-9 (CDK-9) overexpression correlates with worse overall survival patients. Pyranopyrazole pyrazolone privileged development anticancer agents. Inspired by this proven scientific fact, we report...
Carbon monoxide is a key C1 feedstock for the industrial production of hydrocarbons, where it used to make millions tonnes chemicals, fuels, and solvents per annum. Many transition metal complexes can coordinate CO, but formation new C-C bonds in well-defined compounds from scission subsequent coupling two or more CO moieties at centre remains challenge. Herein, we report use low-coordinate iron(II) selective homologation affording unusual squaraines iron carboxylates ambient temperature...
Here, we report an improved synthesis of the bulky phosphanide anion [P(SiiPr3)2]− in synthetically useful yields and its complexation to group 12 metals. The ligand is obtained as sodium salt NaP(SiiPr3)2 1 a 42% isolated yield single step from red phosphorus sodium. This significantly higher-yielding safer preparation compared previously reported this ligand, have thus applied two-coordinate complexes M[P(SiiPr3)2]2 (M = Zn, Cd, Hg). These are all monomeric with nonlinear P–M–P angles...
The enantioselective synthesis of densely functionalized polycarbocycles by the rhodium(<sc>i</sc>)-catalyzed reaction arylboronic acids with alkynyl 1,3-diketones is described. key step in these reactions an alkenyl-to-aryl 1,4-Rh(<sc>i</sc>) migration..
We report the total synthesis of seven Illicium -derived neolignans along with experimental evidence which unites homooligomers and apparent heterooligomers under a new biosynthesis proposal that features single common precursor.
Here, we report the first practical synthesis of bulky phosphanide anion [P(SiiPr3)2]− in synthetically useful yields, and its complexation to Group 12 metals. The ligand is obtained as sodium salt (DME)NaP(SiiPr3)2 1 (DME = 1,2-dimethoxyethane) 36% isolated yield a single step from red phosphorus sodium. This far exceeds previous yields for this (ca. 9.8% overall over 3 steps), have thus applied two coordinate complexes M[P(SiiPr3)2]2 (M Zn, Cd, Hg). These are all monomeric with non-linear...
Abstract Herein we report the synthesis of three heteroleptic first‐row transition metal(II) complexes containing carbazolido NNN pincer ligands and conversion to corresponding metal(I)‐carbonyl via a reductive carbonylation route. These are precatalysts for hydrophosphination activated alkenes, affording cobalt‐catalysed process that solely selectively yields β addition (anti‐Markovnikov) product. The scope this transformation has been investigated using variety alkenes. Isolation...
A magnesium complex (1) featuring a bidentate aminopyridinato ligand is remarkably selective catalyst for the dehydrocoupling of amine-boranes. This reaction proceeds to completion with low loadings (1 mol %) under mild conditions (60 °C), exceeding previously reported s-block systems in terms selectivity, rate, and turnover number (TON). Mechanistic studies by situ NMR analysis reveals be first order both substrate. mechanism proposed account these findings, high TON attributed nature...
Here, we highlight the ability of peri-substitution chemistry to promote a series unique P-P/P-As coupling reactions, which proceed with concomitant C-H bond formation. This dealkanative reactivity represents an interesting and unexpected expansion established family main-group dehydrocoupling reactions. These transformations are exceptionally clean, proceeding essentially quantitatively at relatively low temperatures (70-140 °C), 100% diastereoselectivity in products. The reaction appears...
Two mixed peri-substituted phosphine-chlorostibines, Acenap(PiPr2)(SbPhCl) and Acenap(PiPr2)(SbCl2) (Acenap = acenaphthene-5,6-diyl) reacted cleanly with Grignard reagents or nBuLi to give the corresponding tertiary phosphine-stibines Acenap(PiPr2)(SbRR’) (R, R’ Me, iPr, nBu, Ph). In addition, Pt(II) complex of phosphine-stibine Acenap(PiPr2)(SbPh2) as well Mo(0) Acenap(PiPr2)(SbMePh) were synthesised characterised. two metal complexes characterised by single-crystal X-ray diffraction. The...
Here, we report the first practical synthesis of bulky phosphanide anion [P(SiiPr3)2]− in synthetically useful yields, and its complexation to Group 12 metals. The ligand is obtained as sodium salt NaP(SiiPr3)2 1 a 42% isolated yield single step from red phosphorus sodium. This significant improvement on previously reported this ligand, have thus applied two-coordinate complexes M[P(SiiPr3)2]2 (M = Zn, Cd, Hg). These are all monomeric with non-linear P–M–P angles solid state, DFT...
Abstract Treatment of Acenap(P i Pr 2 )(EH ) (Acenap = acenaphthene‐5,6‐diyl; 1a , E As; 1b P) with Ph 3 C · BF 4 resulted in hydride abstraction to give [Acenap(P )(EH)][BF ] ( 2a 2b P). These represent the first structurally characterised phosphino/arsino‐phosphonium salts secondary arsine/phosphine groups, as well example a Lewis base stabilised primary arsenium cation. Compounds and were deprotonated NaH afford low coordinate species )(E) 3a 3b This provides an alternative practical...
Photochemical synthesis of highly reactive hydroperoxides and their conversion into useful products, such as 1,2,4-trioxanes, are wide interest for synthetic organic chemistry pharmaceutical manufacturing particularly because relevance potential antimalarial anticancer treatment drugs, example, Artemisinin. One class drugs is based on 1,2,4-trioxane scaffolds although production compounds a gram scale challenging due to instability in oxidizable solvents. Furthermore, current methods employ...
Here, we report the first practical synthesis of bulky phosphanide anion [P(SiiPr3)2]− in synthetically useful yields, and its complexation to Group 12 metals. The ligand is obtained as sodium salt (DME)NaP(SiiPr3)2 1 (DME = 1,2-dimethoxyethane) 36% isolated yield a single step from red phosphorus sodium. This far exceeds previous yields for this (ca. 9.8% overall over 3 steps), have thus applied two coordinate complexes M[P(SiiPr3)2]2 (M Zn, Cd, Hg). These are all monomeric with non-linear...
A catalyst-free, low-solvent method for the hydrophosphinylation of isocyanates and isothiocyanates is reported. range phosphorus nucleophiles including secondary phosphine oxides HP(O)R2 (R = Ph, iPr), phosphites HP(O)(OR)2 Me, Et), methyl phenylphosphinate were tested. The procedure tolerated featuring a wide substituents and, with use 4 equiv 2-methyltetrahydrofuran (2-MeTHF), solid substrates can be utilized. Twenty-five compounds prepared improved functional group tolerance compared to...
A series of group 11 m-terphenyl complexes have been synthesized via a metathesis reaction from the iron(II) (2,6-Mes2C6H3)2Fe and (2,6-Xyl2C6H3)2Fe (Mes = 2,4,6-Me3C6H2; Xyl 2,6-Me2C6H3). [2,6-Mes2C6H3M]2 (1, M Cu; 2, Ag; 6, Au) [2,6-Xyl2C6H3M]2 (3, 4, Ag) are dimeric in solid state, although different geometries observed depending on ligand. These feature short metal–metal distances expected range for metallophilic interactions. While 1–4 readily isolated using this metathetical route,...
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Two-coordinate transition metal complexes are exciting candidates for single-molecule magnets (SMMs) because their highly axial coordination environments lead to sizeable magnetic anisotropy. We report a series of five structurally related two-coordinate Fe(II) m-terphenyl (4-R-2,6-Xyl2C6H2)2Fe [R = tBu (1), SiMe3 (2), H (3), Cl (4), CF3 (5)] where, by changing the functionalisation para-substituent (R), we alter function. All field-induced magnets, with relaxation rates that well-described...
A two-coordinate Fe(II) m-terphenyl complex acts as a precatalyst for the hydroamination of isocyanates, affording urea and biuret derivatives, with product selectivity accomplished via modification reaction conditions. Using more nucleophilic amine facilitates insertion up to four isocyanates into N–H bond, triuret tetrauret derivatives.
The fundamental synthetic building blocks FcPH<sub>2</sub> and FcPCl<sub>2</sub> are obtained in high yield excellent purities <italic>via</italic> the fully regiospecific electrophilic monofunctionalisation of ferrocene with P<sub>4</sub>S<sub>10</sub>, thus replacing inconvenient <italic>t</italic>BuLi based procedures.
Coordination chemistry of an acenaphthene peri-backbone-supported phosphino-phosphonium chloride (1) was investigated, revealing three distinct modes reactivity. The reaction 1 with Mo(CO)4(nor) gives the Mo(0) complex [(1)Mo(CO)4Cl] (2), in which ligand exhibits monodentate coordination through phosphine donor and P-P bond is retained. PtCl2(cod) reacts triflate salts to form a mononuclear [(1Cl)PtCl2] (3) binuclear [((1Cl)PtCl)2][2TfO] (4), respectively. In both these complexes, platinum...
Let p : E → B be a principal fibration with classifying map w C. It is well-known that the group [X, Ω C] acts on E] orbit space image of # , where B].The isotropy subgroup X to base point also subgroups for other maps e can definitely change as does.The set homotopy classes lifts f free loop group.If has lift E, -1 (f ) identified cokernel natural homomorphism from this C].As an example, S 2 ] enumerated 4-complex.