A5079674488- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Microscopic Colitis
- Urinary Tract Infections Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Vibrio bacteria research studies
- Antimicrobial Resistance in Staphylococcus
- Aquaculture disease management and microbiota
- Microbial infections and disease research
- Infections and bacterial resistance
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Infectious Diseases and Tuberculosis
- Viral gastroenteritis research and epidemiology
- Amoebic Infections and Treatments
- Salmonella and Campylobacter epidemiology
National Cheng Kung University Hospital
2016-2025
National Cheng Kung University
2009-2025
Tainan Municipal Hospital
2023
Chang Jung Christian University
2016-2022
National Defense Medical Center
2018-2022
Tri-Service General Hospital
2018-2022
Sin-Lau Christian Hospital
2016-2021
University Medical Center
2021
National Yang Ming Chiao Tung University
2018
National Taipei University
2018
Nirmatrelvir/ritonavir (Paxlovid™) is an effective and safe antiviral drug that inhibits the main protease (Mpro), 3CL protease, of SARS-CoV-2. A reduction in COVID-19-related hospitalization or death was observed patients treated with nirmatrelvir/ritonavir within five days symptom onset. Moreover, good oral availability enables usage nirmatrelvir/ritonavir, not only hospitalized patients, but also among outpatients. Nirmatrelvir (PF-07321332) has been demonstrated to stop spread COVID-19...
Background. Extended-spectrum ß-lactamase (ESBL)–producing Enterobacteriaceae isolates are important clinical pathogens. In addition, the efficacy of cefepime for such infections is controversial. Methods. We performed a retrospective study monomicrobial bacteremia caused by ESBL producers at 2 medical centers between May 2002 and August 2007. The patients definitively treated with in vitro active (cases) were compared those carbapenem (controls) propensity score–matched analysis to assess...
Early administration of appropriate antimicrobials has been correlated with a better prognosis in patients bacteremia, but the optimum timing early antibiotic as one resuscitation strategies for severe bacterial infections remains unclear.In retrospective cohort study, adults community-onset bacteremia at emergency department (ED) were analyzed. Effects different cutoffs time to (TtAa) after arrival ED on 28-day mortality examined, adjustment independent predictors identified by multivariate...
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly resulted in a global pandemic with approximately 4 million deaths. Effective oral antiviral agents are urgently needed to treat disease-2019 (COVID-19), block SARS-CoV-2 transmission, and prevent progression illness. Molnupiravir (formerly EIDD-2801), prodrug of beta-d-N4-hydroxycytidine (EIDD-1931) an inhibitor RNA-dependent RNA polymerase, possesses significant activity against SARS-CoV-2. Its...
A new category of cefepime susceptibility, susceptible dose dependent (SDD), for Enterobacteriaceae, has been suggested to maximize its clinical use. However, evidence supporting such a therapeutic strategy is limited. retrospective study 305 adults with monomicrobial Enterobacter cloacae bacteremia at medical center from 2008 2012 was conducted. The patients definitively treated in vitro active (cases) were compared those carbapenem (controls) assess effectiveness. 30-day crude mortality...
Bacteraemia is a critical condition that generally leads to substantial morbidity and mortality. It unclear whether delayed antimicrobial therapy (and/or source control) has prognostic or defervescence effect on patients with source-control-required (ScR) unrequired (ScU) bacteraemia.
The standard antimicrobial therapy for Clostridioides difficile infections (CDIs) is limited to oral fidaxomicin or vancomycin, but these agents are associated with high treatment failure and recurrence rates. Clostridium butyricum had been proven effective in many kinds of gastrointestinal disease. With a less disturbed gut microbiota, we hypothesized that the properties Miyairi Bacteriocin (CBM-B) make it potential therapeutic agent treating patients CDIs. inhibitory effects CBM-B...
Enterobacter cloacae is an important nosocomial pathogen. However, few studies specifically dealing with the clinical characteristics and outcome of extended-spectrum beta-lactamase (ESBL)-producing E. infections have been published. During 8-year period in a medical center, 610 bacteremic isolates, 138 (22.6%) ESBL genes were designated group, 120 (19.6%) cefotaxime-nonsusceptible isolates without phenotype control group. Of former group 133 (96.3%) carried bla(SHV-12) gene, 3 (2.1%) had...
Background The objective of this study was to compare virulence among different Aeromonas species causing bloodstream infections. Methodology/Principal Findings Nine four blood isolates, including A. dhakensis, hydrophila, veronii and caviae were randomly selected for analysis. identified by the DNA sequence matching rpoD. Clinically, patients with dhakensis bacteremia had a higher sepsis-related mortality rate than those other (37.5% vs. 0%, P = 0.028). Virulence tested in C. elegans, mouse...
Although aeromonads are important pathogens causing invasive infections in southern Taiwan, Aeromonas-associated intestinal have been rarely mentioned.The aim of this study was to understand the frequency isolation and clinical significance recovered from adult stool samples Taiwan.During a 15-month period, 514 adults with diarrhea 167 asymptomatic controls were prospectively screened for presence stools. The identity Aeromonas species determined by rpoD sequencing. Clinical information...
Pseudomonas aeruginosa bacteremia is an important cause of nosocomial infections with high morbidity and mortality. Time-to-positivity (TTP) blood cultures considered to be a predictor the clinical outcome for bacteremia. The aim study investigate relationship between TTP outcomes in patients monomicrobial P. bacteremia.From January 2013 June 2014, retrospective cohort was conducted 1200-bed tertiary care hospital. cases were studied. parameters determined analyzed.In 139 bacteremia, ≤ 13...
Bloodstream infections are associated with high morbidity and mortality, both of which contribute substantially to healthcare costs. The effects early administration appropriate antimicrobials on the prognosis timing defervescence bacteremic patients remain under debate.In a 6-year retrospective, multicenter cohort, adults community-onset bacteremia at emergency departments (EDs) were analyzed. period from ED arrival antimicrobial that was regarded as time-to-appropriate antibiotic (TtAa)...
Infiltrative hepatocellular carcinoma (HCC) is often associated with an unfavorable prognosis, posing a challenge in determining the optimal therapeutic approach. Immunotherapy, employing immune checkpoint inhibitors (ICIs), has become preferred first-line treatment for advanced HCC. However, overall effectiveness of ICIs patients infiltrative HCC remains unclear. This study aims to compare effect ICI on clinical outcomes between and non-infiltrative A retrospective cohort consisting...