A5021620552- Congenital heart defects research
- Advanced Fluorescence Microscopy Techniques
- Ultrasound and Hyperthermia Applications
- Cell Image Analysis Techniques
- Congenital Heart Disease Studies
- Coronary Interventions and Diagnostics
- Advanced machining processes and optimization
- Body Contouring and Surgery
- Advanced Surface Polishing Techniques
- Cardiovascular Disease and Adiposity
- Advanced Machining and Optimization Techniques
- Microgrid Control and Optimization
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cancer-related molecular mechanisms research
- Bariatric Surgery and Outcomes
- Cardiovascular Function and Risk Factors
- Ultrasound in Clinical Applications
- Zebrafish Biomedical Research Applications
- Photoacoustic and Ultrasonic Imaging
- Optical Coherence Tomography Applications
- Cardiovascular and Diving-Related Complications
- Autophagy in Disease and Therapy
- Single-cell and spatial transcriptomics
- Islanding Detection in Power Systems
University of Bern
2018-2024
University of Bremen
2023-2024
Rolls-Royce (Germany)
2021
Saarland University
2015-2020
Technische Universität Braunschweig
2020
Saint Louis University
2019
Hasso Plattner Institute
2015-2019
University of Potsdam
2019
Zentrum für Mechatronik und Automatisierungstechnik
2016-2018
Städtisches Klinikum Karlsruhe
2014-2015
Tracheobronchial stenosis, a serious problem in adults and children, has multiple causes been treated many ways. While developing an international multicentre study to evaluate efficacy of airway stents, it was realised that no adequate description central stenosis regarding type, location degree published. Thus, comparing results different treatment modalities centres difficult due lack uniformity classification. Reports are typically descriptive precise classification schemes have not...
During development, mesodermal progenitors from the first heart field (FHF) form a primitive cardiac tube, to which second (SHF) are added. The contribution of FHF and SHF adult zebrafish has not been studied date. Here we find, using genetic tbx5a lineage tracing tools, that ventricular myocardium in is mainly derived
Commercially pure titanium (titanium grade 2), Ti90Al6V4 5) and intermetallic Ti60Al40 (γ-TiAl) were investigated concerning their electrochemical dissolution behavior in aqueous potassium bromide-, sodium chloride- nitrate electrolytes with different pH-values. Therefore, a modified micro-flow cell experiments like cyclic voltammetry, linear sweep voltammetry chronoamperometry performed. The experimental results show that the is influenced by composition of material electrolyte conditions....
ABSTRACT During development, the heart grows by addition of progenitor cells to poles primordial tube. In zebrafish, Wilms tumor 1 transcription factor a (wt1a) and b (wt1b) genes are expressed in pericardium, at venous pole heart. From this pericardial layer, proepicardium emerges. Proepicardial subsequently transferred myocardial surface form epicardium, covering myocardium. We found that while wt1a wt1b expression is maintained proepicardial cells, it downregulated contribute...
PurposeSynchrotron-generated microbeam radiation therapy (MRT) represents an innovative preclinical type of cancer with excellent therapeutic ratio. Beyond local control, metastatic spread is another important endpoint to assess the effectiveness treatment. Currently, no data exist on association between MRT and metastasis. Here, we evaluated ability delay B16F10 murine melanoma progression locoregional spread.Methods MaterialsWe assessed primary tumor response extent metastasis in sentinel...
Due to the demand for environment-friendly passenger planes, aviation industry is forced continually improve efficiency of jet engines. Solutions this reduction could be use high-temperature-resistant materials as engine components, such well-established nickel-based superalloy Inconel 718, well construction aspects streaming behavior vanes. Electrochemical Machining (ECM) a well-known technique bring hard machine material into complex shapes by creating an excellent surface finish. However,...
Question answering (QA) systems are crucial when searching for exact answers natural language questions in the biomedical domain.Answers to many of such can be extracted from 26 millions publications currently included MEDLINE relying on appropriate processing (NLP) tools.In this work we describe our participation task 4b BioASQ challenge using two QA that developed biomedicine.Preliminary results show achieved first and second positions snippet retrieval sub-task generation ideal answers.
Neuronal migration during development is necessary to form an ordered and functional brain. Postmitotic neurons require microtubules dynein move, but the mechanisms by which they contribute are not fully characterized. Using tegmental hindbrain nuclei in zebrafish embryos together with subcellular imaging, optogenetics, photopharmacology, we show that, vivo, centrosome’s position relative nucleus linked greatest motility this cell type. Nevertheless, microtubules, dynein, kinesin-1 essential...
The effect of different pressures (0, 10, 30, 60, 80, 100, 120, or 180 mm Hg) on the ultrasound contrast obtained from sonicated albumin was evaluated by videodensity decay curves in an vitro model immersed a water tank. Decay rates and half-times were calculated at each pressure. A significant (P < 0.0001) relation found between disappearance pressure: higher pressure more rapid disappearance. Release did not result reappearance. Contrast decrease with may microbubble destruction alteration...
This study aimed to evaluate the quality of prescribing cardiovascular medication by a criterion-based approach with reference national treatment guidelines for care patients diabetes mellitus. Case notes and database records diabetic outpatients (age range 15–75 years) managed in secondary clinic major teaching hospital were reviewed 23 criteria previously evaluated tool applied determine adherence guidelines. For 214 (57.5% male, 69.6% type 2 mellitus), mean (SD) age was 52.2 (16.3) years...
Drug repurposing is an important strategy in COVID-19 treatment, but many clinically approved compounds have not been extensively studied the context of embryogenesis, thus limiting their administration during pregnancy. Here we used zebrafish embryo model organism to test effects 162 marketed drugs on cardiovascular development. Among clinic for COVD-19 found that Remdesivir led reduced body size and heart functionality at relevant doses. Ritonavir Baricitinib showed Molnupiravir activity....
In vivo fluorescence microscopy is a powerful tool to image the beating heart in its early development stages. A high acquisition frame rate necessary study fast contractions, but limited intensity requires sensitive cameras that are often too slow. Moreover, problem even more complex when imaging distinct tissues same sample using different fluorophores. We present Paired Alternating AcQuisitions (PAAQ), method cyclic processes multiple channels, which only single (possibly slow) camera.We...
Abstract Drug repurposing is an important strategy in COVID-19 treatment, but many clinically approved compounds have not been extensively studied the context of embryogenesis, thus limiting their administration during pregnancy. Here we used zebrafish embryo model organism to test effects 162 marketed drugs on cardiovascular development. Among clinic for COVD-19 found that Remdesivir led reduced body size and heart functionality at relevant doses. Ritonavir Baricitinib showed Molnupiravir...
In vivo fluorescence microscopy is a powerful tool to image the beating heart in its early development stages. A high acquisition frame rate necessary study fast contractions, but limited intensity requires sensitive cameras that are often too slow. Moreover, problem even more complex when imaging distinct tissues same sample using different fluorophores. We present Paired Alternating AcQuisitions, method cyclic processes multiple channels, which only single (possibly slow) camera. generate...
Microscopy of the beating heart in embryos provides key insights for study its development. However, achieving a sufficiently high framerate is difficult with conventional cameras. Here, we present method to reconstruct an image sequence covering one heartbeat from images acquired over multiple cardiac cycles, each triggered at arbitrary time, by sorting them according their similarity. We formulate this task as traveling salesman problem which efficient solutions are available....
Fluorescence laser-scanning microscopy is a wellestablished imaging technique in biology, available many facilities to investigate structures within live animal embryos such as zebrafish. Laser scanning microscopes (LSM) are limited when used study dynamic heart morphology or function. Despite their ability resolve static cardiac structures, the fast motion of beating introduces severe artifacts scanned images and gating acquisitions heartbeat difficult implement on traditional microscopes....