A5007550367- Zebrafish Biomedical Research Applications
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Cellular Mechanics and Interactions
- Epigenetics and DNA Methylation
- Congenital heart defects research
- Signaling Pathways in Disease
- Long-Term Effects of COVID-19
- Environmental Toxicology and Ecotoxicology
- Phytochemical compounds biological activities
- Retinopathy of Prematurity Studies
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Erythrocyte Function and Pathophysiology
- Heavy Metal Exposure and Toxicity
- Monoclonal and Polyclonal Antibodies Research
- Muscle Physiology and Disorders
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Cardiomyopathy and Myosin Studies
- Water Quality and Pollution Assessment
- Heart Rate Variability and Autonomic Control
University of Bern
2019-2023
Gwangju Institute of Science and Technology
2012-2018
Max Planck Institute of Immunobiology and Epigenetics
2016-2018
University of Freiburg
2017
Paracelsus Medical University
2015
The formation of an immunological synapse (IS) requires tight regulation actin dynamics by many polymerizing/depolymerizing proteins. However, the significance stabilization at IS remains largely unknown. In this paper, we identify a novel function TAGLN2—an actin-binding protein predominantly expressed in T cells—in stabilizing cortical F-actin, thereby maintaining F-actin contents and acquiring LFA-1 (leukocyte function-associated antigen-1) activation after cell receptor stimulation....
Organ regeneration is preceded by the recruitment of innate immune cells, which play an active role during repair and regrowth. Here, we studied macrophage subtypes organ in zebrafish, animal model with a high regenerative capacity. We identified subpopulation expressing Wilms tumor 1b (wt1b), accumulates within regenerating tissues. This wt1b+ population exhibited overall pro-regenerative gene expression profile different migratory behavior compared to remainder macrophages. Functional...
Protein functions are often revealed by their localization to specialized cellular sites. Recent reports demonstrated that swiprosin-1 is found together with actin and actin-binding proteins in the cytoskeleton fraction of human mast cells NK-like cells. However, direct evidence whether regulates dynamics currently lacking. We localizes microvilli-like membrane protrusions lamellipodia exhibits activity. Overexpression enhanced formation cell spreading. In contrast, knockdown showed reduced...
The H2.0-like homeobox transcription factor (HLX) regulates hematopoietic differentiation and is overexpressed in Acute Myeloid Leukemia (AML), but the mechanisms underlying these functions remain unclear. We demonstrate here that HLX overexpression leads to a myeloid block both zebrafish human stem progenitor cells (HSPCs). show downregulation of genes encoding electron transport chain (ETC) components upregulation PPARδ gene expression HSPCs. also results AMPK activation. Pharmacological...
TAGLN is an actin-binding protein family that comprises three isoforms with theorized roles in smooth muscle differentiation, tumour development, lymphocyte activation, and brain chemistry. However, their fundamental characteristics regulation of the actin-based cytoskeleton are not fully understood. Here we show TAGLN2 (including TAGLN1 TAGLN3) extensively nucleates G-actin polymerization under low-salt conditions, where would be completely suppressed. The calponin homology domain loop...
T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, synapse leads to sustained receptor-mediated signalling stabilized adhesion. High resolution microscopy indeed had great impact in understanding dynamic of Trends recent research are now moving towards mechanical part immune system, expanding our knowledge mechanosensitivity, force generation, biophysics cell-cell...
Drug repurposing is an important strategy in COVID-19 treatment, but many clinically approved compounds have not been extensively studied the context of embryogenesis, thus limiting their administration during pregnancy. Here we used zebrafish embryo model organism to test effects 162 marketed drugs on cardiovascular development. Among clinic for COVD-19 found that Remdesivir led reduced body size and heart functionality at relevant doses. Ritonavir Baricitinib showed Molnupiravir activity....
Abstract Drug repurposing is an important strategy in COVID-19 treatment, but many clinically approved compounds have not been extensively studied the context of embryogenesis, thus limiting their administration during pregnancy. Here we used zebrafish embryo model organism to test effects 162 marketed drugs on cardiovascular development. Among clinic for COVD-19 found that Remdesivir led reduced body size and heart functionality at relevant doses. Ritonavir Baricitinib showed Molnupiravir...
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different cell types participate in physiological pathophysiological processes.EVs mediate intercellular communication cell-derived extracellular signalling organelles that transmit specific information from their of origin to target cells.As a result these properties, EVs defined may serve novel tools for various therapeutic approaches, including (a) anti-tumour therapy, (b) pathogen vaccination, (c)...
Metals and metalloids are integral to biological processes play key roles in physiology metabolism. Nonetheless, overexposure some metals or lack of others can lead serious health consequences. In this study, eight zebrafish facilities collaborated generate a multielement analysis their centralized recirculating water systems. We report first set average concentrations for 46 elements detected facilities. Our results help establish an initial baseline trouble-shooting purposes, general safe...