A5085691549- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Amoebic Infections and Treatments
- Parasitic infections in humans and animals
- Ubiquitin and proteasome pathways
- Natural product bioactivities and synthesis
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Parkinson's Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Parasitic Infections and Diagnostics
- HIV Research and Treatment
- melanin and skin pigmentation
- Protease and Inhibitor Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Immunodeficiency and Autoimmune Disorders
- Galectins and Cancer Biology
- Systemic Lupus Erythematosus Research
- Hemophilia Treatment and Research
Grünenthal Group (Germany)
2019-2020
University of Würzburg
2011-2017
Vrije Universiteit Brussel
2008
Background Alveolar echinococcosis, caused by Echinococcus multilocularis larvae, is a chronic disease associated with considerable modulation of the host immune response. Dendritic cells (DC) are key effectors in shaping response and among first encountered parasite during an infection. Although it assumed that E.multilocularis, excretory/secretory (E/S)-products, specifically affects DC to deviate responses, little information available on molecular nature respective E/S-products their...
Tolerogenicity of dendritic cells (DCs) has initially been attributed exclusively to immature/resting stages, while mature/activated DCs were considered strictly immunogenic. Later, all different subsets among the myeloid/conventional and plasmacytoid have shown bear tolerogenic potential, so that tolerogenicity could not be a specific subset. Immunosuppressive treatments immature DC prevent re-programming into mature or upregulated inhibitory surface markers cytokines. Furthermore, T cell...
Parkinson's disease (PD) is characterized at the cellular level by a destruction of neuromelanin (NM)-containing dopaminergic cells and profound reduction in striatal dopamine. It has been shown recently that anti-melanin antibodies are increased sera Parkinson patients, suggesting NM may act as an autoantigen. In this study we tested whether being recognized dendritic (DCs), major cell type for inducing T- B-cell responses vivo. This recognition DCs prerequisite to trigger adaptive...
Abstract DCs represent the major cell type leading to polarized T‐helper (Th) responses in vivo. Here, we asked whether instruction of murine Th2 by matured with proinflammatory cytokine TNF is qualitatively different from maturation types TLR4/MyD88‐dependent variant‐specific surface glycoproteins (VSGs) Trypanosoma brucei ( T. ). The results obtained analyzing DC markers, Notch ligand mRNA, cytokines, asthma, and experimental autoimmune encephalomyelitis (EAE) models as well performing...
Anergic T cells can survive for long time periods passively in a hyporesponsive state without obvious active functions. Thus, the immunological reason their maintenance is unclear. Here, we induced peptide‐specific anergy from mice by coculturing these with immature murine dendritic (DCs). We found that anergic, nonsuppressive IL‐10 − Foxp3 CTLA‐4 + CD25 low Egr2 could be converted into suppressive high resembling type‐1 Treg (Tr1) when stimulated second DCs vitro. Addition of TGF‐β during...
Immature or semi-mature dendritic cells (DCs) represent tolerogenic maturation stages that can convert naive T into Foxp3+ induced regulatory (iTreg). Here we found murine bone marrow-derived DCs (BM-DCs) treated with cholera toxin (CT) matured by up-regulating MHC-II and costimulatory molecules using either high low doses of CT (CThi, CTlo) cAMP, a known mediator signals. However, all three conditions also mRNA both isoforms the molecule cytotoxic lymphocyte antigen 2 (CTLA-2α CTLA-2β)....
Pharmacological inhibition of cathepsin S (CatS) allows for a specific modulation the adaptive immune system and many major diseases. Here, we used NMR fragment screening crystal structure-aided merging to synthesize novel, highly selective CatS inhibitors with picomolar enzymatic Ki values nanomolar functional activity in human Raji cells. Noncovalent hits revealed binding hotspots, while covalent inhibitor structure–activity relationship enabled efficient potency optimization.
Small molecule inhibitors selectively targeting the immunoproteasome subunit β5i are currently being developed for treatment of autoimmune disorders. However, patients carrying loss-of-function mutations in gene encoding (Psmb8) suffer from proteasome-associated autoinflammatory syndromes (PRAAS) emphasizing need to study pharmacological inhibition function human cells. Here, we characterized immunomodulatory potential selective inhibitor ONX 0914 and Bortezomib, a pan-proteasome inhibitor,...
Haemophilia A (HA) is a blood clotting disorder caused by various genetic deficiencies in the factor VIII (FVIII) encoding F8 gene. Patients receiving FVIII replacement therapy are at risk of developing neutralizing antibodies (FVIII inhibitors) rendering ineffective. Immunological tolerance towards can be achieved through immune induction (ITI) protocols some patients but this lengthy and costly desensitization programme. Long-term eradication inhibitors HA could antigen-specific...