A5091652759- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Adipose Tissue and Metabolism
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Neuroscience and Neuropharmacology Research
- Phytoestrogen effects and research
- Estrogen and related hormone effects
- Cardiac pacing and defibrillation studies
- Diet, Metabolism, and Disease
- Ion Channels and Receptors
- Cardiac Structural Anomalies and Repair
- Signaling Pathways in Disease
- Menopause: Health Impacts and Treatments
- Heart Rate Variability and Autonomic Control
- Pancreatic function and diabetes
Virginia Commonwealth University
2021-2024
Instituto Politécnico Nacional
2013-2021
Instituto Nacional de Pediatria
2013-2021
Universidad Nacional Autónoma de México
2020
Center for Research and Advanced Studies of the National Polytechnic Institute
2016
Ca + mishandling due to impaired activity of cardiac sarco(endo)plasmic reticulum 2+ ATPase (SERCA2a) has been associated with the development left ventricular diastolic dysfunction in insulin-resistant cardiomyopathy. However, molecular causes underlying SERCA2a alterations induced by insulin resistance and related metabolic disorders, such as syndrome (MetS), are not completely understood. In this study, we used a sucrose-fed rat model MetS test hypothesis that decreased is mediated...
BackgroundTachycardia and heart rate irregularity are proposed triggers of premature ventricular contraction–induced cardiomyopathy (PVC-cardiomyopathy). Bigeminal atrial contractions (PACs PVCs) increase result in rhythm irregularities but differ their effects on synchrony. Comparing chronic bigeminal PACs with PVCs would provide insights into mechanisms PVC-cardiomyopathy.ObjectiveTo compare the impact hemodynamics, structure, function.MethodsPacemakers were implanted 27 canines to...
We investigated how oxidative stress (OS) alters Ca2+ handling in ventricular myocytes early metabolic syndrome (MetS) sucrose-fed rats. The effects of N-acetyl cysteine (NAC) or dl-Dithiothreitol (DTT) on systolic transients (SCaTs), diastolic sparks (CaS) and waves (CaW), recorded by confocal techniques, L-type current (ICa), assessed whole-cell patch clamp, were evaluated MetS Control cells. exhibited decreased SCaTs CaS frequency but unaffected CaW propagation. In cells, NAC/DTT reduced...
Abstract Frequent premature ventricular contractions (PVCs) promoted eccentric cardiac hypertrophy and reduced ejection fraction (EF) in a large animal model of PVC‐induced cardiomyopathy (PVC‐CM), but the molecular mechanisms markers this hypertrophic remodeling remain unexplored. Healthy mongrel canines were implanted with pacemakers to deliver bigeminal PVCs (50% burden 200–220 ms coupling interval). After 12 weeks, left (LV) free wall samples studied from PVC‐CM Sham groups. In addition...