A5044639156- Theoretical and Computational Physics
- Advanced Thermodynamics and Statistical Mechanics
- Physics of Superconductivity and Magnetism
- Micro and Nano Robotics
- Computational Drug Discovery Methods
- Diffusion and Search Dynamics
- Neurobiology and Insect Physiology Research
- Pickering emulsions and particle stabilization
- Bioinformatics and Genomic Networks
- Nonlinear Dynamics and Pattern Formation
- Modular Robots and Swarm Intelligence
- Microtubule and mitosis dynamics
- Scientific Computing and Data Management
- Statistical Mechanics and Entropy
- Machine Learning in Bioinformatics
- Protist diversity and phylogeny
- Insect and Arachnid Ecology and Behavior
- Magnetic properties of thin films
- Plant Reproductive Biology
- Machine Learning and Data Classification
- Dust and Plasma Wave Phenomena
- Mitochondrial Function and Pathology
- Material Dynamics and Properties
- Cellular Mechanics and Interactions
- Meta-analysis and systematic reviews
Lawrence Livermore National Laboratory
2014-2023
Los Alamos National Laboratory
2011-2013
Princeton University
2009-2012
University of Notre Dame
2003-2005
Ames Research Center
2002
Mitochondria are dynamic organelles that undergo constant remodeling through the regulation of two opposing processes, mitochondrial fission and fusion. Although several key regulators physiological stimuli have been identified to control fusion, role morphology in processes remains be determined. To address this knowledge gap, we investigated whether morphological features extracted from time-lapse live-cell images mitochondria could used predict fate. That is, asked if a mitochondrion is...
We analyze the jamming transition that occurs as a function of increasing packing density in disordered two-dimensional assembly disks at zero temperature for ``Point $J$'' recently proposed phase diagram. measure total number moving and transverse length region, find power law divergence increases toward critical density. This provides evidence $T=0$ is second order transition. Additionally, we multiscaling, indicating importance long tails velocity fluctuations.
We numerically demonstrate bidirectional sorting of flocking particles interacting with an array asymmetric barriers. Each particle aligns the average swimming direction its neighbors according to Vicsek model and experiences additional steric interactions as well repulsion from fixed show that preferentially localize one side barrier over time, this rectification can be reversed by adjusting particle-particle exclusion radius or noise term in equations motion. These results provide a...
Precise formation of morphogen gradients is essential to the establishment reproducible pattern in development. Mechanisms proposed for obtaining requisite precision range from simple models with few parameters more complex involving many regulated quantities. The synthesis-diffusion-degradation (SDD) model a relatively explaining Bicoid gradient Drosophila melanogaster, which steady-state characteristic length determined solely by rates diffusion and degradation morphogen. In this work, we...
We consider a system of charged particles interacting with an unscreened Coulomb repulsion in two-dimensional parabolic confining trap. The static charge on portion the is twice as large remaining particles. separate into shell structure those greater situated farther from center As we vary ratio number two species, find that for certain configurations, symmetry arrangement inner cluster singly matches outer ring doubly These matching configurations have higher melting temperature and...
Exotic vortex states with long range attraction and short repulsion have recently been proposed to arise in superconducting hybrid structures multi-band superconductors. Using large scale simulations we examine the static dynamic properties of such interacting random periodic pinning. In absence pinning this system does not form patterns but instead completely phase separates. When is present there a transition from inhomogeneous homogeneous configurations similar wetting phenomenon. Under...
Minimizing the human and economic costs of COVID-19 pandemic future pandemics requires ability to develop deploy effective treatments for novel pathogens as soon possible after they emerge. To this end, we introduce a new computational pipeline rapid identification characterization binding sites in viral proteins along with key chemical features, which call chemotypes, compounds predicted interact those same sites. The composition source organisms structural models associated an individual...
For collections of particles in a thermal bath interacting with an asymmetric substrate, it is possible for ratchet effect to occur where the undergo net dc motion response ac forcing. Ratchet effects have been demonstrated variety systems including colloids as well magnetic vortices type-II superconductors. Here we examine case active matter or self-driven substrates. Active include self-motile colloidal undergoing catalysis, swimming bacteria, artificial swimmers, crawling cells, and motor...
Abstract Current methods of addressing novel viruses remain predominantly reactive and reliant on empirical strategies. To develop more proactive methodologies for the early identification treatment diseases caused by like HIV Sars-CoV-2, we focus host targeting, which requires identifying altering human genetic factors that are crucial to life cycle these viruses. this end, present three classification models pinpoint genes interest. For each one, thoroughly analyze current predictive...
Recently there has been growing interest in what is called active matter, or collections of particles that are self driven rather than with an external field. Examples such systems include swimming bacteria, flocks birds fish, and pedestrian flow. There have also recent experimental realizations self-driven using colloidal undergoing self-catalytic interactions. One example this light-induced catalysis where the colloids become presence light. Almost all these studies performed absence a...
There are many examples of particle assemblies where the particles have competing repulsive and attractive interactions. In solid state systems, it has recently been proposed that exotic vortex states in type-I type-II superconducting hybrids type-1.5 superconductors fall into this category. soft matter interactions can arise for charged colloids with short range attraction or multiple length scale Systems shown to exhibit a wide variety patterns including stripes, labyrinths, bubbles,...
1 Abstract Minimizing the human and economic costs of COVID-19 pandemic future pandemics requires ability to develop deploy effective treatments for novel pathogens as soon possible after they emerge. To this end, we introduce a unique, computational pipeline rapid identification characterization binding sites in proteins viruses well core chemical components with which these interact. We combine molecular-level structural modeling clustering cheminformatic techniques computationally...
Ensuring the validity of results from funded programs is a critical concern for agencies that sponsor biological research. In recent years, open science movement has sought to promote reproducibility by encouraging sharing not only finished manuscripts but also data and code supporting their findings. While these innovations have lent support third-party efforts replicate calculations underlying key in scientific literature, fields inquiry where privacy considerations or other sensitivities...
We demonstrate that the fluctuation theorem of Gallavotti and Cohen can be used to characterize class dynamics arises in nonthermal systems collectively interacting particles driven over random quenched disorder. By observing frequency entropy-destroying trajectories, we show there are specific dynamical regimes near depinning which this holds. Hence a significantly wider nonequilibrium than previously considered. discuss how could tested where noisy appear at transition from pinned moving...