Postprandial hyperglycemia is an early defect of type 2 diabetes and one primary anti-diabetic targets. Treatment postprandial can be achieved by inhibiting intestinal α-glucosidase, the key enzyme for oligosaccharide digestion further glucose absorption. Grape pomace winemaking byproduct rich in bioactive food compounds such as phenolic antioxidants. This study evaluated potential two specific grape extracts determining their antioxidant anti-postprandial hyperglycemic activities vitro...

Norton grape is one of the most important wine grapes in Southern and Midwestern states generates massive pomace byproducts. The objective this study to characterize antioxidant compounds activity extract (GPE) further assess potential health promoting properties GPE using an animal disease model. total phenolic content anthocyanins were 475.4 mg gallic acid equiv/g 156.9 cyanidin 3-glucoside equiv/g, respectively. Catechin epicatechin 28.6 24.5 mg/g, Other major antioxidants included...

Chitosan films incorporated with various concentrations of the complex β-cyclodextrin and essential oils (β-CD/EO) were prepared investigated for antimicrobial, mechanical, physical properties. Four bacterial strains that commonly contaminate food products chosen as target bacteria to evaluate antimicrobial activity films. The incorporation β-CD/EO significantly increased activities chitosan against Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, Listeria monocytogenes. It...

This study was to evaluate whether rice protein hydrolysates with strong antioxidant activity can be used prevent lipid oxidation and improve shelf-life of meat products. Rice proteins were hydrolysed by three microbial proteases further separated sequential ultrafiltration 12 hydrolysate fractions. The resulting first evaluated for free radical scavenging capacity. oxygen absorbance capacity (ORAC) the fractions varied significantly ranging between 34.2 87.3 μmol Trolox equivalents (TE)/g...

Dietary antioxidants may provide a cost-effective strategy to promote health in obesity by targeting oxidative stress and inflammation. We recently found that the antioxidant-rich grape skin extract (GSE) also exerts novel anti-hyperglycemic activity. This study investigated whether 3-month GSE supplementation can improve stress, inflammation, hyperglycemia associated with Western diet-induced obesity. Young obese (DIO) mice were randomly divided three treatment groups (n = 12): standard...

Three extraction strategies including Soxhlet extraction, conventional solid-liquid and ultrasonic-assisted (UAE) were compared for their efficiency to extract phenolic antioxidants from Virginia-grown soybean seeds. Five solvents evaluated in UAE the extraction. The extracts total contents (TPC), oxygen radical absorbance capacity (ORAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH(*)) scavenging activities. results showed that improved of compounds by >54% extractions. Among tested solvents, 50%...

An extract of noni (Morinda citrifolia) fruits has shown potent inhibitory activity on gut bacterial β-glucuronidase, which could help reduce irinotecan-induced diarrhea. In this study, four β-glucuronidase inhibitors were obtained following bioactive assay-guided isolation, including two sesquineolignans, (7S,8S,7'R,8'R)-isoamericanol B (1) and americanol (2), dineolignans, moricitrins A (3) (4). Compounds 2-4 are new, the absolute configuration compound 1 was determined for first time....

Abstract α‐Glucosidases have been a major target in controlling and managing postprandial blood glucose therefore diabetes treatment. This study aims to further identify purify active compounds from the most ethyl acetate fraction collected previously Tinta Cão grape pomace extract (TCEE) using newly developed highly effective immobilization method, including obtaining shown inhibit enzyme. Purification used crosslinked chitosan beads with α‐glucosidases bound polymer, which acted as...

A principal active antimicrobial compound, 2-(3',5'-dibromo-2'-methoxyphenoxy)-3,5-dibromophenol, was isolated from the methanol extract of Phyllospongiapapyracea via bioassay-guided fractionation and isolation. The crude purified compound were assayed to determine minimal - inhibitory concentration bactericidal (MBC) using broth. microdilution method. found be highly against Bacillus subtilis Staphylococcus aureus at MIC=1 μg/mL, Campylobacter jejuni MIC=2 gg/mL, Pseudomonas aeruginosa...

This study was to evaluate the potential for developing superior antioxidative peptides derived from pea protein isolates that could be used prevent meat lipid oxidation and improve its shelf-life. Pea isolate hydrolyzed with individual microbial proteases further fractionated by sequential ultrafiltration (molecular weight cut-off of 3 10 kDa) a total 12 hydrolysate fractions. Their antioxidant activities were evaluated compared. The fractions exerted significant oxygen radical absorbance...

While grape pomace contains considerable amounts of polyphenols, dietary antioxidants have been associated with a reduced risk type 2 diabetes. We previously reported strong α‐glucosidase inhibition exhibited by red wine extracts, implying potential role in diabetes management. In the current study, we aim to understand relationships between this activity and antioxidant capacity these extracts. Chambourcin, Merlot, Norton, Petit Verdot, Syrah Tinta Cão pomaces extracted 50% acetone were...

Abstract isolation, structure determination and antiproliferative activity of three novel acetogenins, muricins J, K L

Abstract The three new annonaceous acetogenins, muricins M (I) and N (II), muricenin (III), are isolated from the fruit powder of Graviola (Annona muricata).