A5064369492- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Prion Diseases and Protein Misfolding
Lundbeck (Denmark)
2018-2019
Abstract Neurodegenerative diseases such as Alzheimer’s disease are characterized by the progressive spreading and accumulation of hyper-phosphorylated tau protein in brain. Anti-tau antibodies have been shown to reduce pathology vivo models antibody-mediated clearance exerted microglia has proposed a contributing factor. By subjecting primary cultured vitro anti-phospho-tau complex with pathological tau, we show that internalise degrade manner is dependent on FcγR interaction functional...
Abstract Introduction The abnormal hyperphosphorylation of the microtubule‐associated protein tau plays a crucial role in neurodegeneration Alzheimer's disease (AD) and other tauopathies. Methods Highly specific selective anti‐pS396‐tau antibodies have been generated using peptide immunization with screening against pathologic hyperphosphorylated from rTg4510 mouse AD brains selection vitro vivo seeding assays. Results antibody C10.2 bound specifically to pS396‐tau an IC 50 104 pM detected...