A5026857946- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuropeptides and Animal Physiology
- Neurological disorders and treatments
- Ion channel regulation and function
- Botulinum Toxin and Related Neurological Disorders
- Neuroendocrine regulation and behavior
- Hypothalamic control of reproductive hormones
- Retinal Development and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Heat shock proteins research
- Advanced Biosensing Techniques and Applications
- RNA regulation and disease
- Nanopore and Nanochannel Transport Studies
- Growth Hormone and Insulin-like Growth Factors
- Congenital heart defects research
- Genetics and Neurodevelopmental Disorders
- Spaceflight effects on biology
- Barrier Structure and Function Studies
Lundbeck (Denmark)
2012-2025
Drug Discovery Laboratory (Norway)
2018
McGill University
2000-2005
Inserm
1996-2001
Université Claude Bernard Lyon 1
1997-2001
Douglas Mental Health University Institute
2000
The medial septum-diagonal band complex (MSDB) contains cholinergic and non-cholinergic neurons known to play key roles in learning memory processing, the generation of hippocampal theta rhythm. Electrophysiologically, several classes have been described MSDB, but their chemical identity remains be fully established. By combining electrophysiology with single-cell RT-PCR, we identified four MSDB vitro. first class displayed slow-firing little or no Ih, expressed choline acetyl-transferase...
Glutamate is the main excitatory neurotransmitter in central nervous system (CNS) and a major player complex brain functions. Glutamatergic transmission primarily mediated by ionotropic glutamate receptors, which include NMDA, AMPA kainate receptors. However, exerts modulatory actions through family of metabotropic G-protein-coupled receptors (mGluRs). Dysfunctions glutamatergic neurotransmission have been implicated etiology several diseases. Therefore, pharmacological modulation has widely...
The GluN2D subunit of the NMDA receptor is prominently expressed in basal ganglia and associated brainstem nuclei, including subthalamic nucleus (STN), globus pallidus, striatum, substantia nigra. However, little known about how GluN2D-containing receptors contribute to synaptic activity these regions. Using Western blotting STN tissue punches, we demonstrated that rat throughout development [age postnatal day 7 (P7)–P60] adult (age P120). Immunoelectron microscopy brain showed predominantly...
Parkinson’s disease (PD) is a progressive neurodegenerative disorder for which there no existing therapeutic approach to delay or stop progression. Genetic, biochemical and pre-clinical studies have provided evidence that leucine-rich-repeat-kinase-2 (LRRK2) kinase involved in the pathogenesis of PD, small molecule LRRK2 inhibitors represent novel potential approach. However, potentially adverse target-related effects been discovered lung kidneys knock-out (ko) mice rats. It unclear if ko...
Transferrin receptor-1 (TfR1) transcytosis-mediated delivery of therapeutic monoclonal antibodies across the blood-brain barrier (BBB) is a promising concept in drug development for CNS disorders. We sought to investigate brain and efficacy Aducanumab (Adu), an anti-Aβ antibody, when fused mouse TfR1-binding Fab fragment as BBB shuttle (TfR1-Adu). Automated 3D light sheet fluorescence imaging coupled with computational analysis was applied evaluate IgG distribution plaque counts throughout...
Dopaminergic (DAergic) neurons in the ventral tegmental area express both KCNQ2 and KCNQ4 channels, which opening is expected to decrease neuronal excitability via hyper-polarization. Because psychotic symptoms are believed be associated with an increased of dopamine (DA) cells mesencephalon, KCNQ channels might represent a new potential target for treatment psychosis. The aim our study was investigate antipsychotic-like channel modulation activity within mesolimbic DAergic system. We report...
Abstract Introduction The abnormal hyperphosphorylation of the microtubule‐associated protein tau plays a crucial role in neurodegeneration Alzheimer's disease (AD) and other tauopathies. Methods Highly specific selective anti‐pS396‐tau antibodies have been generated using peptide immunization with screening against pathologic hyperphosphorylated from rTg4510 mouse AD brains selection vitro vivo seeding assays. Results antibody C10.2 bound specifically to pS396‐tau an IC 50 104 pM detected...
1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order investigate biological alterations induced by this microdeletion, we generated novel mouse model (Df(h1q21)/+) and characterized it in broad test battery focusing on schizophrenia-related assays. Df(h1q21)/+ mice displayed hyperactivity response amphetamine challenge sensitivity the disruptive effects phencyclidine hydrochloride (PCP) prepulse inhibition. Probing direct...
It is widely believed that expression of the vesicular glutamate transporter genes VGLUT1 and VGLUT2 restricted to glutamatergic neurons two transporters segregate in different sets neurons. Using single-cell multiplex RT-PCR (sc-RT-mPCR), we show mRNAs were coexpressed most sampled from rat hippocampus, cortex, cerebellum at postnatal Day (P)14 but not P60. In accordance, changes mRNA concentrations found occur these other brain areas between P14 P60, as revealed by semiquantitative...
Synucleinopathies are a group of diseases characterized by brain aggregates α-synuclein (α-syn). The gradual accumulation α-syn and the role inflammation in early-stage pathogenesis remain poorly understood. We explored this interaction inducing chronic common pre-clinical synucleinopathy mouse model. Three weeks post unilateral intra-striatal injections human pre-formed fibrils (PFF), mice underwent repeated intraperitoneal 1 mg/ml lipopolysaccharide (LPS) for 3 weeks. Histological...
Assimilated evidence indicates that the neurotoxic potential of amyloid β (Aβ) peptide and an alteration in level growth factor(s) may possibly be involved loss neurons observed brain patients suffering from Alzheimer disease (AD), prevalent cause dementia elderly. In present study, using receptor binding assays immunocytochemistry, we evaluated pharmacological profile insulin-like factor-I (IGF-I) receptors distribution IGF-I immunoreactivity frontal cortex, hippocampus, cerebellum AD...
Phosphodiesterase (PDE) 10A is highly expressed in medium spiny neurons of the striatum, at confluence corticostriatal glutamatergic and midbrain dopaminergic pathways, both believed to be involved physiopathology schizophrenia. There a growing body evidence suggesting that targeting PDE10A may beneficial for treatment positive symptoms The aim present study was investigate how inhibition modulates mesolimbic neurotransmission. We found selective inhibitor, MP-10, blocked...
Recently,
Attention deficit hyperactivity disorder (ADHD) is the most frequently diagnosed neurodevelopmental worldwide. Affected individuals present with hyperactivity, inattention, and cognitive deficits display a characteristic paradoxical response to drugs affecting dopaminergic system. However, underlying pathophysiology of ADHD how this relates transmission remains be fully understood. Sorcs2-/- mice uniquely recapitulate symptoms reminiscent in humans. Here, we show that lack SorCS2 results...