A5013639019- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Nerve injury and regeneration
- Diabetes Treatment and Management
- Ion channel regulation and function
- Regulation of Appetite and Obesity
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Transcranial Magnetic Stimulation Studies
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Anesthesia and Neurotoxicity Research
- Diet and metabolism studies
- Parkinson's Disease Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Neuroinflammation and Neurodegeneration Mechanisms
Mental Health Services
2010-2025
Frederiksberg Hospital
2024-2025
Copenhagen University Hospital
2006-2025
Capital Region of Denmark
2010-2025
University of Copenhagen
2016-2025
Faculty of Public Health
2025
Rigshospitalet
2006-2020
The University of Texas Medical Branch at Galveston
2000
Bispebjerg Hospital
1995
Rutgers, The State University of New Jersey
1994
The maternal separation paradigm has been applied to C57BL/6J mice as an animal developmental model for understanding structural deficits leading abnormal behaviour. A (MS) was used on postnatal day (PND) 9, where the pups were removed from their mother 24 h (MS24). When 10 weeks old, level of anxiety and fear measured with two behavioural tests; open field test elevated plus maze test. Barnes platform spatial learning, memory by using acquisition trials followed reverse trial sessions. MS24...
Acetylcholine (ACh) regulates many key functions of the CNS by activating cell surface receptors referred to as muscarinic ACh (M 1 –M 5 mAChRs). Like other mAChR subtypes, M 4 is widely expressed in different regions forebrain. Interestingly, mAChRs are coexpressed with D dopamine a specific subset striatal projection neurons. To investigate physiological relevance this subpopulation modulating dopamine-dependent behaviors, we used Cre/loxP technology generate mutant mice that lack only...
Abstract Rationale Glucagon-like peptide-1 (GLP-1) receptor agonists reduce alcohol consumption in rodents and non-human primates. Semaglutide is a new long-acting GLP-1 agonist, widely used the clinic against type 2 diabetes obesity. It also reported to intake rodents. Objectives This study investigates possible inhibitory effect of semaglutide on alcohol-preferring African green monkeys. Methods We performed vehicle-controlled male monkeys that had demonstrated preference for alcohol. In...
Abstract Repeated maternal separation of rat pups during the early postnatal period may affect brain‐derived neurotrophic factor (BDNF) or neurons in brain areas that are compromised by chronic stress. In present study, a highly significant increase hippocampal BDNF protein concentration was found adult rats as neonates had been subjected to 180 min daily compared with handled separated for 15 daily. unchanged frontal cortex and hypothalamus/paraventricular nucleus. Expression mRNA CA1, CA3,...
The reinforcing effects of cocaine have been related to increased extracellular concentrations dopamine in the ventral striatum. Several studies suggest that M 5 muscarinic receptors facilitate striatal release. We tested hypothesis are decreased receptor-deficient mice using chronic intravenous self-administration extensively backcrossed mice. also assessed whether operant performance generally, rather than specifically, was altered mutant To this end, we evaluated both food-maintained...
Abstract Agonism of the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) has been effective at treating aspects addictive behavior for a number abused substances, including cocaine. However, molecular mechanisms and brain circuits underlying therapeutic effects GLP-1R signaling on cocaine actions remain elusive. Recent evidence revealed that endogenous within forebrain lateral septum (LS) acts to reduce cocaine-induced locomotion conditioned place preference, both considered dopamine...
Abstract Muscarinic cholinergic receptors of the M 5 subtype are expressed by dopamine‐containing neurons ventral tegmentum. These modulate activity midbrain dopaminergic neurons, which play an important role in mediating reinforcing properties abused psychostimulants like cocaine. The potential effects cocaine was investigated using receptor‐deficient mice a model acute self‐administration. ‐deficient self‐administered at significantly lower rate than wild‐type controls. In conditioned...
Abstract Central administration of neuropeptide Y (NPY) causes both anxiolysis and sedation. Previous studies suggest that effects are mediated via NPY Y1 receptors. However, most these were carried out before the advent specific receptor ligands. Therefore, a potential role for other receptors in anxiety sedation remains possibility. In present study, we addressed this issue by testing intracerebroventricular (i.c.v.) injection as well agonists ([D‐His 26 ]NPY), Y2 (C2‐NPY), Y5 ([cPP 1–7...
Disturbances in central dopaminergic neurotransmission are believed to be centrally involved the pathogenesis of schizophrenia. Central and cholinergic systems interact muscarinic agonist xanomeline has shown antipsychotic effects clinical studies. Preclinical studies indicate that M 4 receptor subtype (mAChR) modulates activity system this specific mAChR is mediating antipsychotic-like xanomeline. A neuronal subpopulation expresses mAChRs together with D 1 dopamine receptors seems...
Electroconvulsive stimulation (ECS) is one of the strongest stimulators hippocampal neurogenesis in rodents that represents a plausible mechanism for efficacy electroconvulsive therapy (ECT) major depressive disorder. Using design-based stereological cell counting, we recently documented an initial 2.6-fold increase following clinical relevant schedule ECS, treatment also rescuing depression-like behavior rats. However, these results gave no demonstration longevity newly generated neurons....
Abstract Dopamine plays a key role in the cellular and behavioral responses to drugs of abuse, but implication metabotropic regulatory input dopaminergic neurons on acute drug effects subsequent drug-related behavior remains unclear. Here, we used chemogenetics [Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)] modulate dopamine signaling activity before cocaine administration mice. We show that chemogenetic inhibition ventral tegmental area (VTA) differentially affects...
Abstract Dependence on opioids and the number of opioid overdose deaths are serious escalating public health problems, but medication-assisted treatments for addiction remain inadequate many patients. Glucagon-like pepide-1 (GLP-1) is a gut hormone neuropeptide with actions in peripheral tissues brain, including regulation blood glucose food intake. GLP-1 analogs, which approved diabetes medications, can reduce reinforcing rewarding effects alcohol, cocaine, amphetamine, nicotine rodents....
This study investigates the effects of muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM) VU0467154 on development, incubation, and expression amphetamine sensitization in mice, immediate early genes medial prefrontal cortex after induction sensitization, as well spontaneous locomotion several aspects sensorimotor function. Mice were pretreated with during phase, before challenge test, or both. A separate cohort was treated incubation period. Tests function...
The neurotransmitter dopamine plays important roles in modulating cognitive, affective, and motor functions. Dysregulation of dopaminergic neurotransmission is thought to be involved the pathophysiology several psychiatric neurological disorders, including schizophrenia, Parkinson's disease drug abuse. Dopaminergic systems are regulated by cholinergic, especially muscarinic, input. Not surprisingly, increasing evidence implicates muscarinic acetylcholine receptor-mediated pathways as...