A5041269947- Prenatal Substance Exposure Effects
- Neonatal Health and Biochemistry
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience of respiration and sleep
- Cancer Treatment and Pharmacology
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Nausea and vomiting management
- Pregnancy and preeclampsia studies
- Pharmacogenetics and Drug Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Opioid Use Disorder Treatment
- Iron Metabolism and Disorders
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Treatments and Studies
- Metabolism and Genetic Disorders
- Hemoglobinopathies and Related Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Anesthesia and Sedative Agents
Thomas Jefferson University
2016-2025
Thomas Jefferson University Hospital
2011-2024
Johns Hopkins Hospital
2024
Berkeley College
2019
University of California, Berkeley
2019
Icahn School of Medicine at Mount Sinai
2017
Pediatrics and Genetics
2017
Bridge University
2016
Creative Commons
2016
Medication Management (United States)
2016
To determine whether high risk scores on preoperative STOP-BANG (Snoring, Tiredness during daytime, Observed apnea, blood Pressure, Body mass index, Age, Neck circumference, Gender) questionnaires evaluation correlated with a higher rate of complications obstructive sleep apnea syndrome (OSAS).Historical cohort study.Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.Adult patients undergoing elective surgery at tertiary care center who were administered the questionnaire for 3...
Current pharmacologic treatment of the neonatal abstinence syndrome with morphine is associated a lengthy duration therapy and hospitalization. Buprenorphine may be more effective than for this indication.
ABSTRACT Posaconazole oral suspension is an extended-spectrum triazole that should be taken with food to maximize absorption. A new posaconazole tablet formulation has demonstrated improved bioavailability over the in healthy adults a fasting state. This study evaluated effects of concomitant medications altering gastric pH (antacid, ranitidine, and esomeprazole) motility (metoclopramide) on pharmacokinetics tablets. was prospective open-label 5-way crossover 20 volunteers. In each treatment...
Circadian (diurnal) rhythm is an integral part of the physiology body; specifically, sleep, feeding behavior and metabolism are tightly linked to light-dark cycle dictated by earth's rotation.The present study examines effect diurnal on gene expression in subcutaneous adipose tissue overweight mildly obese, healthy individuals. In this well-controlled clinical study, biopsies were taken morning, afternoon evening from individuals three arms: treatment with weight loss drug...
Acid peptic disorders are the result of distinctive, but overlapping pathogenic mechanisms leading to either excessive acid secretion or diminished mucosal defense. They common entities present in daily clinical practice that, owing their chronicity, represent a significant cost healthcare. Key elements success controlling these have been development potent and safe drugs based on physiological targets. The histamine-2 receptor antagonists revolutionized treatment safety efficacy profile....
In utero exposure to drugs of abuse can lead neonatal abstinence syndrome, a condition that is associated with prolonged hospitalization. Buprenorphine partial mu-opioid agonist used for treatment adult detoxification and maintenance but has never been administered neonates opioid syndrome. The primary objective this study was demonstrate the feasibility and, extent possible in size study, safety sublingual buprenorphine Secondary goals were evaluate efficacy relative standard therapy...
ABSTRACT Aims More than half of infants exposed to opioids in utero develop neonatal abstinence syndrome (NAS) severity require pharmacological therapy. Current treatments are associated with prolonged hospitalization. We sought optimize the dose sublingual buprenorphine treatment NAS. Design Randomized, Phase 1, open‐label, active‐control clinical trial comparing oral morphine. Setting Large, urban, tertiary care hospital. Participants Twenty‐four term requiring for Measurements Outcomes...
The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled study reports the safety, pharmacokinetics and responsiveness of metabotropic glutamate receptor (mGluR) activator fasoracetam (NFC-1), 30 adolescents, age 12-17 years with ADHD, harboring mutations mGluR network genes. Mutation status was double-blinded. A single-dose pharmacokinetic profiling from 50-800 mg...
Abstract Letermovir (AIC246, MK‐8228) is a human cytomegalovirus terminase inhibitor indicated for the prophylaxis of infection and disease in allogeneic hematopoietic stem cell transplant recipients that also being investigated use other settings. Many patients receive immunosuppressant drugs, which several have narrow therapeutic ranges. There potential coadministration letermovir with these agents, any effect on their pharmacokinetics (PK) must be understood. Five phase 1 trials were...
ABSTRACT The potential for interactions between caspofungin and nelfinavir or rifampin was evaluated in two parallel-panel studies. In study A, healthy subjects received a 14-day course of alone (50 mg administered intravenously [IV] once daily) ( n = 10) with (1,250 orally twice 9) (600 10). B, 14 28-day daily), IV coadministered on the last days, 12 daily). coadministration/administration geometric mean ratio area under time-concentration profile calculated 24-h period following dosing...
<h3>Background</h3> The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8<sup>+</sup>, but not CD4<sup>+</sup>, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice. Here, the vaccine Ad5-GUCY2C-PADRE was evaluated a first-in-man phase I clinical study of patients with early-stage to assess its safety and immunological efficacy. <h3>Methods</h3> Ten surgically-resected stage or II (pN0) colon received single intramuscular...
Abstract Background Doravirine/islatravir (DOR/ISL 100/0.25 mg) is a daily, oral, fixed-dose combination being developed for the treatment of HIV infection. As people living with are commonly prescribed antacids or acid-reducing agents, we investigated effects pantoprazole, proton pump inhibitor (PPI), on DOR/ISL pharmacokinetics (PK). Methods This was randomized, open-label substudy in participants without HIV. Single-dose (100/0.75 administered, followed by washout interval at least 7...
ABSTRACT Ondansetron is an anti‐emetic 5‐HT3 receptor antagonist being investigated for treating neonatal opioid withdrawal syndrome (NOWS). Sparse PK data were analyzed from a multicenter, double‐blind clinical trial with 98 mother/neonate dyads. Pregnant women use disorder randomized to receive either placebo or ondansetron 8 mg intravenously within 4 h of delivery. Neonates born mothers who received 0.07 mg/kg orally once every 24 up five doses. Using current data, model parameters...
The drugs and drug dose regimens used to treat opioid withdrawal symptoms in newborns with utero exposure have been developed a mostly empiric fashion. Clonidine has long as an adjunct but explored part of opioid-free approach primary therapy. tools pharmacometrics can provide path for rational exploration response. Antenatal results post-natal neonatal syndrome (NOWS) cardinal symptomatology the central autonomic nervous systems gastrointestinal tract. natural history NOWS is characterized...
Low-dose aspirin is recommended for prevention of hypertensive disorders pregnancy (HDP) and preterm birth (PTB) in high-risk pregnancies. There limited data on factors impacting response pregnancy. We aimed to evaluate predictors association with outcome a prospective study pregnancies taking 81 mg daily. Aspirin was evaluated Platelet Function Assay-100 (PFA-100) epinephrine closure time at baseline (< 16 weeks' gestation), follow-up 1 (2-4 weeks after initiation), 2 (28-32 gestation)....
Journal Article Optimizing Estimation: Perspective on Drug Dosing Using New CKD-EPI Equations Get access Edward J Filippone, Filippone Department of Medicine, Sidney Kimmel Medical College Thomas Jefferson University, Philadelphia, PA, United States Search for other works by this author on: Oxford Academic Google Scholar Walter K Kraft Pharmacology, Physiology, and Cancer Biology, Address correspondence to at: Pharamcology, 132 S 10th St., PA 19107, States. Tel 215 955 9077; e-mail [email...