The 575 inhabitants of the remote Anatolian village Karain suffered 11 deaths from pleural mesothelioma in 1975/76 and there were five cases fibrosing pleurisy. In previous years had been 25 mesothelioma. Calcified plaques common on survey radiography. Asbestos does not occur local soil or rock, nor is it handled village, but a few fibres found water. Fibres also tissue two examined. Inhabitants neighbouring villages are free

Lubricin may be an important barrier to the development of corneal and conjunctival epitheliopathies that occur in dry eye disease contact lens wear.To test hypotheses lubricin (ie, proteoglycan 4 [PRG4 ]), a boundary lubricant, is produced by ocular surface epithelia acts protect cornea conjunctiva against significant shear forces generated during eyelid blink deficiency increases stress on promotes damage.Human, porcine, mouse tissues cells were processed for molecular biological,...

ABSTRACT PURPOSE: To obtain normative values of angle kappa in a normal population by synoptophore and Orbscan II to compare the reliability these devices. METHODS: Three hundred consecutive healthy individuals were enrolled study. A complete orthoptic ophthalmologic examination was performed. Synoptophore corneal topography used measure kappa. evaluate association refraction measures, further classified according degree myopia hyperopia. The spherical equivalent error measures grouped into...

purpose. To investigate possible corneal biomechanical changes in patients with diabetes mellitus and understand the influence of such on intraocular pressure measurements. methods. The study group was composed 120 eyes from 61 healthy control subjects 81 43 diabetic subjects. IOP measured first an ocular response analyzer (ORA) subsequently a Goldmann applanation tonometer (GAT). Central thickness (CCT) ultrasonic pachymeter attached to ORA. Axial length (AL), anterior chamber depth (ACD),...

Erratum in Invest Ophthalmol Vis Sci. 2014 Sep;55(9):5588. Miller, William S [coorected to L].

Abstract Optoelectronic biointerfaces have made a significant impact on modern science and technology from understanding the mechanisms of neurotransmission to recovery vision for blinds. They are based cell interfaces organic or inorganic materials such as silicon, graphene, oxides, quantum dots, π ‐conjugated polymers, which dry stiff unlike cell/tissue environment. On other side, wet soft hydrogels recently been started attract attention bioelectronics because its high‐level...

Photovoltaic biointerfaces offer wireless and battery-free bioelectronic medicine via photomodulation of neurons. Near-infrared (NIR) light enables communication with neurons inside the deep tissue application high photon flux within ocular safety limit exposure. For that, nonsilicon are highly demanded for thin flexible operation. Here, we devised a quantum dot (QD)-based photovoltaic biointerface that stimulates cells spectral transparency window by using NIR (λ = 780 nm). Integration an...

Abstract Optoelectronic biointerfaces offer a wireless and nongenetic neurostimulation pathway with high spatiotemporal resolution. Fabrication of low‐cost flexible optoelectronic that have photogenerated charge injection densities clinically usable cell stimulation mechanism is critical for rendering this technology useful ubiquitous biomedical applications. Here, supercapacitor combined organic optoelectronics by integrating RuO 2 into donor–acceptor photovoltaic device architecture...

To compare the efficacy, safety, and long-term results of intraocular pressure (IOP) reduction by diode laser contact cyclophotocoagulation (DCPC) Ahmed glaucoma valve (AGV) implant in cases neovascular glaucoma.A total 66 eyes patients with were prospectively assigned to either DCPC or AGV implantation. All underwent a baseline complete ophthalmologic examination IOP measurement Goldmann applanation tonometry before after 1,3, 6, 12, 24 months follow-up. Complications number medications...

We hypothesized that women with primary (pSS) and secondary Sjögren syndrome (sSS; systemic lupus erythematosus [SLE] or rheumatoid arthritis [RA]) have meibomian gland dysfunction (MGD). sought to test our hypothesis.Subjects pSS, sSS + SLE, RA, non-SS-related MGD were recruited from the Sjögren's Syndrome Foundation outpatient clinics at Tufts University School of Dental Medicine Brigham Women's Hospital. The control population was Greater Boston area. After providing written informed...

Neural interfaces are the fundamental tools to understand brain and cure many nervous-system diseases. For proper interfacing, seamless integration, efficient safe digital-to-biological signal transduction, long operational lifetime required. Here, we devised a wireless optoelectronic pseudocapacitor converting optical energy capacitive currents by dissociating photogenerated excitons in photovoltaic unit effectively routing holes supercapacitor electrode pseudocapacitive...

There is growing interest in generating vitro models of tissues and tissue-related diseases to mimic normal tissue organization pathogenesis for different purposes. The retina a highly complex multicellular where the cellular components relative each other critical retinal function. Many retinopathies arise due disruption this order. In study, we aimed generate coculture model retina-derived cells, namely RPE Müller multiplexed 3D hydrogels. Using methacrylated gelatin (GelMA)-based...

Purpose: The corneal niche is composed of various cell types, including limbal stem cells (LSCs), epithelial (CECs), and neuronal cells. LSCs are pivotal for regeneration, CECs maintain the transparency, contribute to sensory trophic functions. Despite advances in research, interplay among these types within remains insufficiently understood. This study aims engineer organoids combining LSCs, CECs, create a robust model studying explore their transplantation potential. Methods: SHSY‐5Y were...

Aims/Purpose: Nanomaterial based bioelectronics have been effectively developed as optoelectronic bio‐interfaces for neural stimulation and can be fabricated from diverse substances to adapt cellular environments. In this study, we employed silver bismuth sulfide (AgBiS2) quantum dot (QD)‐based interfaces stimulated by near‐infrared light. Methods: Primary neuron isolation culture on AgBiS2 QD photovoltaic device indium tin oxide (ITO) control was performed. Cell viability assessed CTG, MTT,...

Purpose: The corneal niche is composed of various cell types, including limbal stem cells (LSCs), epithelial (CECs), and neuronal cells. LSCs are pivotal for regeneration, CECs maintain the transparency, contribute to sensory trophic functions. Despite advances in research, interplay among these types within remains insufficiently understood. This study aims engineer organoids combining LSCs, CECs, create a robust model studying explore their transplantation potential. Methods: SHSY‐5Y were...

Aims/Purpose: Nanomaterial based bioelectronics have been effectively developed as optoelectronic bio‐interfaces for neural stimulation and can be fabricated from diverse substances to adapt cellular environments. In this study, we employed silver bismuth sulfide (AgBiS2) quantum dot (QD)‐based interfaces stimulated by near‐infrared light. Methods: Primary neuron isolation culture on AgBiS2 QD photovoltaic device indium tin oxide (ITO) control was performed. Cell viability assessed CTG, MTT,...

To establish the intraobserver and interobserver reliability of rebound tonometer (RBT) in healthy schoolchildren to test patient tolerance an unanesthetized eye.To examine reproducibility RBT, 2 experienced ophthalmologists undertook 3 consecutive intraocular pressure (IOP) measurements with RBT without anesthetic 304 eyes 152 schoolchildren. Any pain or discomfort by children was recorded. Intraobserver reliabilities were established calculating correlation coefficients (r).Of patients, 78...

To compare the central corneal thickness (CCT), axial length (AL), anterior chamber depth (ACD), and lens (LT) measured with Lenstar those obtained ultrasound pachymetry A-scan contact (ASU) in children.ODs of 565 school children were included. All measurements 30 min after instilling 1% tropicamide. For each instrument, three consecutive per child performed. Initially, examiner 1 performed to obtain CCT, AL, ACD, LT. Later, 2 CCT. Finally, ASU was used by Four parameters compared using...