Lu Zhai

ORCID: 0000-0002-5084-9382
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About
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Research Areas
  • Antimicrobial Resistance in Staphylococcus
  • Antimicrobial Peptides and Activities
  • Liver Disease Diagnosis and Treatment
  • Biochemical and Structural Characterization
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Liver Disease and Transplantation
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Monoclonal and Polyclonal Antibodies Research
  • Viral-associated cancers and disorders
  • Nutrition and Health in Aging
  • Hepatitis C virus research
  • vaccines and immunoinformatics approaches
  • Hepatitis B Virus Studies
  • Bacteriophages and microbial interactions
  • Lymphoma Diagnosis and Treatment
  • GDF15 and Related Biomarkers

Shenzhen Institute for Drug Control
2024

Tianjin People's Hospital
2016-2023

Heilongjiang Bayi Agricultural University
2018-2020

Cachexia is a complicated metabolic syndrome mainly associated with cancers, characterized by extreme weight loss and muscle wasting. It debilitating condition that negatively affects prognosis survival. However, there currently no effective pharmacological intervention can reverse body improve physical performance in patients cachexia. Growth differentiation factor 15 (GDF15) suppress appetite regulate energy balance through binding to glial cell-derived neurotrophic receptor alpha-like...

10.1080/19420862.2024.2416453 article EN cc-by-nc mAbs 2024-10-14

Abstract Background and aim The literature is sparse on the association between serum liver fibrosis markers development of hepatic decompensation in patients with compensated cirrhosis. We aimed to assessed whether are predictive occurrence decompensation. Methods ascertained 688 cirrhotic varying etiologies, December 2015 2019. Serum hyaluronic acid (HA), laminin (LN), collagen IV (CIV), N-terminal propeptide type III (PIIINP) levels were measured at enrollment. All subjects followed for...

10.1186/s12876-023-02877-2 article EN cc-by BMC Gastroenterology 2023-09-19

The impact of epidemic Staphylococcus aureus (S. aureus) on public health is increasing. Because the abuse antibiotics, antibiotic resistance S. Thus, there an urgent need to develop new immunotherapies and immunoprophylaxes. Previous studies showed that GapC protein aureus, which a surface with high glyceraldehyde 3-phosphate dehydrogenase activity, transferrin binding other biological activities, highly conserved. induces effective humoral immune response in vivo. However, B-cell epitopes...

10.1371/journal.pone.0190452 article EN cc-by PLoS ONE 2018-01-05

8556 Background: The level of circulating EBV DNA concentration is a prognostic marker in patients with some EBV-associated malignant diseases. To evaluate the impact serum and anti-EBV antibodies T-NHL, this prospective study was conducted by our cancer center. Methods: From Jan 2002 to Dec 2006, paired plasma samples from 125 previously untreated T-NHL were collected subjected real-time quantitative polymerase chain reaction (PCR) assay for measurement an immunoenzyme antibodies(VCA-IgA,...

10.1200/jco.2008.26.15_suppl.8556 article EN Journal of Clinical Oncology 2008-05-20

Objective To evaluate the value of endoscopic ultrasonography(EUS) alone for early liver cirrhosis and diagnostic efficacy EUS combined with histopathology (LH) stiffness measurement (LSM) cirrhosis. Methods Data 226 patients chronic lesions who underwent endoscopy at Tianjin Second People's Hospital were collected to assess esophageal gastric varices. Liver fibrosis was assessed by LH LSM determined Fibroscan. Models EUS-LSM, EUS-LH, LSM-LH, ELL (EUS, LH) constructed predict...

10.3760/cma.j.issn.1007-5232.2019.02.007 article EN 2019-02-20
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