A5008587567- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- Cell Adhesion Molecules Research
- Genital Health and Disease
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- Palliative Care and End-of-Life Issues
- Renal and related cancers
- HIV, Drug Use, Sexual Risk
- Cervical Cancer and HPV Research
- Dysphagia Assessment and Management
- Diagnosis and treatment of tuberculosis
- Urological Disorders and Treatments
- Tuberculosis Research and Epidemiology
- Urologic and reproductive health conditions
- Chronic Kidney Disease and Diabetes
- Ethics in Clinical Research
- HIV, TB, and STIs Epidemiology
- HIV-related health complications and treatments
- Female Genital Mutilation/Cutting Issues
- Cancer survivorship and care
- Pancreatic and Hepatic Oncology Research
- Caveolin-1 and cellular processes
Albany Medical Center Hospital
2009-2024
Our Lady's Hospital
2013-2024
Barts Health NHS Trust
2023
Royal London Hospital
2018-2023
Tallaght University Hospital
2013-2023
North Manchester General Hospital
2007-2022
Irish Hospice Foundation
2021
Pennine Acute Hospitals NHS Trust
2006-2018
Crozer-Keystone Health System
2016
British HIV Association
2015
These guidelines are an update for 2015 of the 2008 UK management syphilis. The writing group have piloted new BASHH guideline methodology, notably using GRADE system assessing evidence and making recommendations. We made significant changes to recommendations screening infants born mothers with positive syphilis serology facilitate accurate timely communication between teams caring mother baby we developed a birth plan. Procaine penicillin is now alternative, not preferred treatment, all...
*Manchester Centre for Sexual Health, The Hathersage Centre, 280, Upper Brook Street, Manchester M13 OFH; † Department of Genitourinary Medicine, Mortimer Market Off Capper London WC1E 6JB; ‡ Ambrose King Royal Hospital, Turner E1 1BB; §Department Whittall Street Clinic, B4 6DH; Outpatients Department, North General Pennine Acute Hospitals NHS Trust, Crumpsall, 9WL; †† Clinical Virology, Infirmary, Oxford Road, ‡‡ Infirmary Edinburgh, 51 Little France Cr, Old Dalkeith Edinburgh EH16 4SA, UK...
Cellular migration, over simple surfaces or through complex stromal barriers, requires coordination between detachment/re-adhesion cycles, involving structural components of the extracellular matrix and their surface-binding elements (integrins), precise regulation pericellular proteolytic microenvironment. It is now apparent that several proteases protease inhibitors, most notably urokinase plasminogen activator (uPA) inhibitor type-1 (PAI-1), also interact with cell surface receptors...
Plasminogen activator inhibitor-1 (PAI-1), a major regulator of the plasmin-based pericellular proteolytic cascade, is significantly increased in human arterial plaques contributing to vessel fibrosis, arteriosclerosis and thrombosis, particularly context elevated tissue TGF-β1. Identification molecular events underlying PAI-1 induction response TGF-β1 may yield novel targets for therapy cardiovascular disease.Reactive oxygen species are generated within 5 minutes after addition quiescent...
<h3>Objective</h3> To determine the prevalence of newly diagnosed hepatitis C virus (HCV) and associated risk behaviours among men who have sex with (MSM) in Manchester. <h3>Method</h3> A survey MSM attending four genitourinary medicine clinics Manchester was carried out over 9 months 2013. Participants were asked about recent sexual behaviour, recreational drug use HIV status. All offered an HCV test. <h3>Results</h3> Overall, 2030 completed a questionnaire accepted Of whom, 0.9% (18) HCV,...
Abstract Transforming growth factor‐β1 (TGF‐β1) stimulates expression of plasminogen activator inhibitor type‐1 (PAI‐1), a serine protease ( SERPIN ) important in the control stromal barrier proteolysis and cell‐to‐matrix adhesion. Pharmacologic agents that target MEK (PD98059, U0126) or src family (PP1) kinases attenuated TGF‐β1‐dependent PAI‐1 transcription R22 aortic smooth muscle cells. Pretreatment with PP1 at concentrations inhibited also blocked ERK1/2 activation/nuclear accumulation...
This study was designed to investigate the association of oral ulceration and health factors, together with psycho-social well-being in Behçet's disease (BD), clarify importance support patients overall management BD. The comprised a cohort 146 BD (mean age ± SD = 39.65 13.20) 20 recurrent aphthous stomatitis (RAS) 42.32 11.32). Oral ulcer severity score (OUSS), current activities form (BDCAF), hospital anxiety depression scale (HADS), work social adjustment (WSAS) were investigated. risk...
We describe a series of 11 high-risk neonates with infective endocarditis (IE) in this retrospective review. Previously IE has rarely been diagnosed newborns and is usually fatal. The frequency was 4.3 cases per 100 patients. Five patients survived. Microorganisms included gram positives such as S. aureus coagulase-negative Staphylococcus, negatives Klebsiella pneumoniae, Enterobacter cloacae, Enterococcus faecalis, Serratia marcescens, Acinetobacter calcoaceticus. Echocardiographic location...
The AromaScan system was used to analyse vaginal swabs from 68 women attending a genitourinary clinic. Using clinical criteria, subjects were assessed for bacterial vaginosis. After training the recognise patterns generated four patients with and without vaginosis, 16 of 17 (94%) remaining correctly identified as having condition. positive predictive value test 61.5%. These results indicate that technology may be screening
Malignant transformation of mammalian cells with ras family oncogenes results in dramatic changes cellular architecture and growth traits. The generation flat revertants v-K- -transformed renal by exposure to the histone deacetylase inhibitor sodium butyrate (NaB) was previously found be dependent on transcriptional activation PAI-1 (SERPINE1) gene (encoding type-1 urokinase tissue-type plasminogen activators). NaB-initiated expression preceded induced cell spreading entry into G 1 arrest....
The burden of disease relating to undiagnosed HIV infection is significant in the UK. BHIVA (British Association) recommends population screening high prevalence areas, expanding outside traditional antenatal/GUM settings.RUClear 2011-12 piloted testing settings using home-sampling kits (dry-blood-spot testing) ordered online. Greater Manchester residents (≥age 16) could request via an established, online chlamydia service (www.ruclear.co.uk). Participant attitudes towards this new were...