A5047246306- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- Advanced Sensor and Energy Harvesting Materials
- Nanomaterials and Printing Technologies
- Quantum Dots Synthesis And Properties
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Additive Manufacturing and 3D Printing Technologies
- Nanocluster Synthesis and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene research and applications
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Organic Electronics and Photovoltaics
- Bacteriophages and microbial interactions
- Advanced Biosensing Techniques and Applications
- Carbon Nanotubes in Composites
- HIV Research and Treatment
- Thermal properties of materials
- Organic Light-Emitting Diodes Research
- Characterization and Applications of Magnetic Nanoparticles
- Photochemistry and Electron Transfer Studies
- Lanthanide and Transition Metal Complexes
- Bacillus and Francisella bacterial research
- Nanoplatforms for cancer theranostics
National Research Council Canada
2015-2025
National Academies of Sciences, Engineering, and Medicine
2012-2014
Steacie Institute for Molecular Sciences
2007-2012
Institut National de la Recherche Scientifique
2009
University of Guelph
2009
University of Ottawa
2009
Institute for Biological Sciences
2009
Institute for Microstructural Sciences
2009
Western University
2000-2008
University of British Columbia
2004-2008
A series of vancomycin-modified nanoparticles were developed and employed in magnetic confinement assays to isolate a variety Gram-positive Gram-negative bacteria from aqueous solution. We determined that the orientation/architecture vancomycin on surface overall coverage is critical mediating fast effective interactions between nanoparticle pathogen cell wall only one modified leads efficient reproducible capture several important pathogenic bacteria. Interestingly, as increase diameter...
Clusters of iron oxide nanoparticles encapsulated in a pH-responsive hydrogel are synthesized and studied for their ability to alter the T(2)-relaxivity protons. Encapsulation clusters with hydrophilic coating is shown enhance transverse relaxation rate by up 85% compared no coating. With use pH-sensitive hydrogel, difficulties inherent comparing particle samples eliminated clear increase relaxivity as swells demonstrated. Agreement Monte Carlo simulations indicates that lower diffusivity...
A silver molecular ink platform formulated for screen, inkjet, and aerosol jet printing is presented. simple formulation comprising neodecanoate, ethyl cellulose, solvent provides improved performance versus that of established inks, yet with economics. Thin, screen-printed traces exceptional electrical (<10 mΩ/□/mil or 12 μΩ·cm) mechanical properties are achieved following thermal photonic sintering, the latter having never been demonstrated silver-salt-based inks. Low surface roughness,...
Conjugated polymer extraction (CPE) has been shown to be a highly effective method isolate high-purity semiconducting single-walled carbon nanotubes (sc-SWCNTs). In both literature reports and industrial manufacturing, this enabled enrichment of sc-SWCNTs with high purity (≥99.9%). High selectivity is typically obtained in nonpolar aromatic solvents, yet polar solvents may provide process improvements terms yield, efficiency. Using an amphiphilic fluorene-alt-pyridine conjugated copolymer...
The reductive desorption of a self-assembled monolayer (SAM) fluorescent thiol molecule (BodipyC10SH) from Au was characterized using electrochemistry and epi-fluorescence microscopy. Molecular luminescence is quenched near metal surface, so fluorescence only observed for molecules reductively desorbed then separated the electrode surface. Fluorescence imaging showed that selective, with occurring different regions depending on extent negative potential excursion. When desorbed, were...
The release profile of ligands from copper formate complexes during thermal decomposition influences the morphology and electrical properties their films.
High-purity semiconducting single-walled carbon nanotubes (sc-SWCNTs) are promising for portable and high-sensitivity gas sensors because of their excellent physical electrical properties. Here, we describe the synthesis a novel indigo-fluorene-based copolymer (PFIDBoc) that has been designed to selectively enrich sc-SWCNTs with purity (>99.9%) yet contain latent function in form tert-butoxy (t-BOC)-protected amine can be later revealed exploited dioxide (CO2) sensing. SWCNTs wrapped PFIDBoc...
Photophysical properties of three types dye-doped silica nanoparticles (NPs) with different dye−silica interactions have been investigated. In two cases the are noncovalent, where tris(2,2′-bipyridine)ruthenium(II) chloride (Rubpy) is attracted to network electrostatically and tetramethylrhodamine-dextran (TMR-Dex) trapped inside matrix through spatial/steric hindrance. third case, tetramethylrhodamine-5-isothiocyanate (TRITC) modified 3-aminopropyltriethoxysilane (APTES) form TMR-APTES...
Because antibodies are highly target-specific and nanoparticles possess diverse, material-dependent properties that can be exploited in order to label potentially identify biomolecules, the development of antibody−nanoparticle conjugates (nanoconjugates) has huge potential biodiagnostics. Here, we describe a novel superparamagnetic nanoconjugate, one whose recognition component is single-domain antibody. It active toward its target Staphylococcus aureus, displays long shelf life, lacks...
Screen printing is the most common method used for production of printed electronics. Formulating copper (Cu) inks that yield conductive fine features with oxidation and mechanical robustness on low-temperature substrates will open up opportunities to fabricate cost-effective devices. We have formulated a screen-printable Cu metal-organic decomposition (MOD) ink comprising formate coordinated 3-(diethylamino)-1,2-propanediol, fractional amount nanoparticles (CuNPs), binder. This simple...
Monitoring the structural health of composites during manufacturing and in‐service is desirable to alert against damage or deterioration conditions beyond an acceptable level. Wireless sensors embedded into materials that can endure forming curing carbon fiber‐reinforced polymer laminates will open door automated near‐field detection key metrics such as temperature, strain, defects. Current sensing technologies are generally too intrusive fragile be reliably expensive applied commercially....
Functional superparamagnetic colloids possessing high saturation magnetization are prepared by emulsification of nanoparticles (SPM NPs) and heterogeneous polymerization. The consist a core densely packed NPs encapsulated within thin polymer shell. cores made emulsifying SPM toluene into an aqueous surfactant solution, subsequently condensing the emulsion droplets removal solvent generating clusters NPs. By tuning condition, this approach allows for control over size from approximately 40 to...
Unnatural D-amino acids bearing endocyclic nitrones were developed for live-cell labelling of the bacterial peptidoglycan layer. Metabolic incorporation D-Lys and D-Ala derivatives different was observed in E. coli, L. innocua, lactis. The incorporated these bacteria then rapidly underwent strain-promoted alkyne-nitrone cycloaddition (SPANC) reactions affording chemically modified bacteria.
Pyridine derivatives coordinated to copper(<sc>ii</sc>) formates are shown have lower decomposition temperatures than the alkylamine analogues.
Maleimide-modified monolayer-protected gold nanoparticles (MPGN) are prepared from the protected furan−maleimide via thermally reversible Diels−Adler reaction when required. These maleimide-MPGNs serve as a general platform allowing for Diels−Alder with furan-modified MPN to prepare larger 3D networks reversibly.
Abstract: Following infection, HIV establishes reservoirs within tissues that are inaccessible to optimal levels of antiviral drugs or cells where lies latent, thus escaping the action anti-HIV drugs. Macrophages a persistent reservoir for and may contribute rebound viremia observed after antiretroviral treatment is stopped. In this study, we further investigate potential poly(lactic- co -glycolic) acid (PLGA)-based nanocarriers as new strategy enhance penetration therapeutic molecules into...
Abstract A new broadband UV light‐based processing method for a screen printable silver oxalate molecular ink is developed that enables structural electronics to be produced on complex thermoformed 3D objects. The production of these devices driven by the light‐induced reduction form an interfacial nanoparticle layer allows transition viscous liquid intermediate and elongate up 50% without cracking during thermoforming. Ultimately, this development with significantly less limitations...
The reductive and oxidative desorption of a BODIPY labeled alkylthiol self-assembled monolayer (SAM) on Au was studied using electrochemical methods coupled with fluorescence microscopy image analysis procedures to monitor the removal adsorbed layer. Two SAMs were formed two lengths alkyl chain (C10 C16). fluorescent moiety used is known form dimers which through donor−acceptor energy transfer results in red-shifted fluorescence. Fluorescence from monomer dimer study nature desorbed...
A Norrish type II reaction of an aryl ketone monolayer-protected colloid was investigated for the first time. Photolysis mercaptoundecanophenone-modified gold colloid, MUP-MPC, generates free acetophenone in solution and nonene-modified MPC via triplet excited state 1,4-biradical intermediate. The is being developed as a probe conformational mobility these unique environments.
Monolayer-protected nanoparticles (MPNs) with average core sizes of 1.7- (small), 2.2- (medium) and 4.5-nm (large) diameter have been prepared functionalized a variety aryl ketone substrates, namely, 11-mercaptoundecaphenone (1), 1-(4-hexyl-phenyl)-11-mercaptoundecanone (2), 1-[4-(11-mercaptoundecyl)phenyl]hexanone (3), or 1-[4-(11-mercaptoundecyl)phenyl]undecanone (4). Upon irradiation in benzene solution, the ketone-modified MPNs undergo Norrish type II photoreaction yield alkene-...
Acyl and alkyl radicals generated photochemically in a solution containing monolayer-protected gold nanoparticles are shown to efficiently liberate the alkylthiolate ligands into as thioacetyl or sulfide, respectively. This radical-induced reaction initiates coalescence of cores facilitate an increase core size. The photoinitiated radical also liberates monolayers from two-dimensional surfaces.