A5000576072- Adaptive optics and wavefront sensing
- Systemic Lupus Erythematosus Research
- Advanced optical system design
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Astronomy and Astrophysical Research
- Renal Diseases and Glomerulopathies
- Digital Holography and Microscopy
- Astronomical Observations and Instrumentation
- Advanced Measurement and Metrology Techniques
- Diabetes Treatment and Management
- Gestational Diabetes Research and Management
- Calibration and Measurement Techniques
- Optical Wireless Communication Technologies
- Biomarkers in Disease Mechanisms
- Optical Coherence Tomography Applications
- Vasculitis and related conditions
- Optical measurement and interference techniques
- Congenital Heart Disease Studies
- Pancreatic function and diabetes
- Advanced Measurement and Detection Methods
- Birth, Development, and Health
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Padua
2018-2024
National Institute for Astrophysics
2024
Osservatorio Astronomico di Padova
2022-2024
Vita-Salute San Raffaele University
2009-2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2023
IRCCS Ospedale San Raffaele
2012-2022
San Raffaele University of Rome
1996-2013
University of Milan
1996-1997
Human Leukocyte Antigen (HLA)-G is involved in reprogramming immune responses at fetal-maternal interface during pregnancy. We evaluated the genetic diversity of 3' Un-Translated Region (UTR) HLA-G, previously associated with HLA-G mRNA post-transcriptional regulation, women unexplained Recurrent Pregnancy Loss (RPL), 2 pregnancy losses (RPL-2, n=28), or 3 more (RPL-3, n=24), and 30 a history successful Results showed RPL-2, but not RPL-3, compared to controls: i) higher frequency 14bp Ins...
Hypercoagulability and pregnancy morbidity are hallmarks of the antiphospholipid syndrome (APS). Catastrophic (CAPS) is a potentially life-threatening omplication APS, with widespread acute thrombotic microangiopathy (TMA) that can be precipitated by delivery result in multiorgan damage. Unrestrained activation complement cascade involved, favoring endothelial activation, tissue factor expression leukocytes, platelet aggregation. The block, which interrupts this amplification cycle, could...
Objective. Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association pregnancy complications antiphospholipid syndrome (APS). Methods. We enrolled 55 APS who were seeking 2 Italian hospitals. Antiphospholipid antibodies (aPL), including anticardiolipin antibodies, anti-β -glycoprotein I lupus-like...
The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the 221 pregnancies from 181 patients, consecutively followed in a single Italian reference centre 2001 to 2009. All patients were prospectively with monthly visits. Pregnancy was compared previous obstetrical history. patient population comprised five groups: primary antiphospholipid syndrome (PAPS, 39 pregnancies), associated rheumatic disease (APS/RD, 17 other RD (92 isolated...
OBJECTIVE To determine the proportion of patients with gestational diabetes mellitus (GDM) who have serological characteristics typical IDDM. RESEARCH DESIGN AND METHODS Islet cell antibodies (ICAs), insulin autoantibodies (IAAs), GAD65, and IA-2 were measured in 145 pregnant women GDM, 33 impaired glucose tolerance (IGT), 73 normal (NGT). ICAs by indirect immunofluorescence; GAD65 antibodies, a radio-ligand immunoassay incorporating 35S-labeled recombinant antigen; IAAs, liquid-phase...
Systemic lupus erythematosus (SLE) preferentially affects women of childbearing age. Miscarriages or fetal death, intrauterine growth restriction (IUGR), preterm delivery, preeclampsia and disease flares complicate pregnancy in SLE patients. Treatment is challenging due to the need prevent exacerbations limit obstetrical complications, while showing an acceptable safety profile for both mother fetus. We collected data from 74 pregnancies 53 patients prospectively followed a dedicated...
Pregnancy complications, such as preeclampsia (PEc), have an increased incidence among patients with type 1 diabetes (T1DM), possibly because of maternal vascular involvement. The prototypic long pentraxin, pentraxin 3 (PTX3) is acute phase reactant critically associated injury. PTX3 concentrations selectively increase in pregnant women PEc. Here, we measured levels 37 consecutive T1DM. Compared healthy at identical gestational ages, was significantly elevated diabetes. Patients pre-existing...
The MezzoCielo (or "half of the sky") is a telescope that aims to revolutionize way astronomical observations are carried out: once operational, it will be able continuously patrol whole sky due its extremely large field view estimated around 10 4 square degrees, showing, at same time, spatial resolution required for scientific purposes. It monocentric optical device designed on concept an sphere; latter requires filling inner volume with special fluid in order actually convergent reasonable...
The impact of hypertension in the pregnancies from autoimmune patients is not unequivocally defined. We have prospectively followed 168 135 four Italian centres to verify potential antiphospholipid syndrome (APS). rate preeclampsia, mean neonatal weight and gestational age at delivery were significantly lower with both APS than or alone. This information may be relevant for counselling care these patients.
Mezzocielo is a proposed innovative type of telescope, conceived for achieving simultaneous observations the available sky using single monocentric collecting optical unit and leaving to an array correctors purpose detecting final starlight. Thanks spherical field lenses, encompassing fluid illuminating correctors, telescope allows realize whole-sky surveying (the estimated Field View more than 10 thousand square degrees), with aim detect observe space debris, even if other possibilities are...
Mezzocielo (or "half of the sky") is a concept for single large monocentric optical system composed by tessellated spherical container filled with low refractive index liquid characterized an extremely high transparency. This allows continuous monitoring whole sky number mass produced correcting cameras. In comparison existing projects efficiency and relatively aperture. The current status development aim producing prototype one meter class size being reported.
The FlyEye design makes its debut in the ESA's NEOSTEL developed by OHB-Italia. This pioneering telescope integrates a monolithic 1-meter class primary mirror feeding 16 CCD cameras for discovering Near-Earth Object (NEO) and any of transient phenomena. OHB-Italia is prime contractor, receiving extended support from Italian National Institute Astrophysics (INAF) NEOSTED program's integration testing. distinctive splits Field View into channels, creating unique multi-telescope system with...
We developed a new opto-mechanical tool to quickly align an optical beam reference mechanics. In the alignment of SOXS Common Path, one sub-systems instrument, we used referenced (and characterized) detector master laser mechanical structure subsystem, and place individual components beam. Based on that experience, conceptualized prototype effective much more efficient easier handle for alignment. A sphere is 3D printed host small bare-board CMOS with sensor plane passing through center...
MezzoCielo telescope aims to be a revolutionary optical instrument, designed exhibit field of view around 104 square degrees. As such, it will able carry out whole-sky patrolling, which could exploited, for instance, track space debris or localize transient phenomena. From an stand-point, the is monocentric lens, composed by outer glass shell enclosing inner cavity filled with fluid (having proper refractive index light convergence). mechanical point view, instead, given limitations related...
OBJECTIVE To evaluate whether the presence of insulin antibodies (IAs) may preclude optimization metabolic control during pregnancy and affect outcome in women with IDDM. RESEARCH DESIGN AND METHODS IAs were measured by radiobinding assay 44 IDDM referred to Diabetes Pregnancy Outpatients' Clinic 46 pregnancies. Age, duration IDDM, (HbA1c, mean pre- postprandial capillary blood glucose, frequency hypo- or hyperglycemia), requirement at 1st 3rd trimester pregnancy, BM1, weight gain recorded....
Mezzocielo (or half of the sky) is a concept for new class telescopes where full spherical optical surface made by filling with liquid structure built up lenses and almost covering an entire sphere. Lenses same existing ones can be arranged, example like faces dodecahedron, in order to build sphere 1 4m diameter. Liquid low refractive index high transparency are available electronic cooling industry devices strong aberrations but consistently identical over basically any direction sky...