A5102717216- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Tracheal and airway disorders
- Childhood Cancer Survivors' Quality of Life
- Microbial infections and disease research
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- Medical Research and Treatments
- Airway Management and Intubation Techniques
- Neurogenetic and Muscular Disorders Research
- Viral Infections and Immunology Research
- Mycobacterium research and diagnosis
- Congenital Heart Disease Studies
- Infant Development and Preterm Care
- Plant Disease Resistance and Genetics
- Congenital heart defects research
- Neonatal Health and Biochemistry
- Child and Adolescent Health
- Insects and Parasite Interactions
- ATP Synthase and ATPases Research
- Genetic and Kidney Cyst Diseases
- Head and Neck Surgical Oncology
- Parvovirus B19 Infection Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
Ljubljana University Medical Centre
2011-2023
Očesna Klinika UKC Ljubljana
2019-2021
Temple Street Children's University Hospital
2016
Uniwersytecki Szpital Dziecięcy
2016
Children's Clinical University Hospital
2015-2016
Abstract Human bocavirus (HBoV) infection is reported worldwide and may cause severe respiratory tract infections. The aim of the present study was to assess prevalence HBoV, other viral pathogens, in a 2‐year retrospective children admitted hospital, investigate whether loads HBoV DNA were associated with severity infection. Between April 2007 March 2009, 891 samples from 760 hospital acute tested for presence viruses by real‐time PCR or direct immunofluorescence testing. detected using...
Summary We report the isolation of emerging fungal pathogen Rasamsonia aegroticola , which belongs argillacea species complex, from a respiratory sample patient with cystic fibrosis. This filamentous fungus, resembling members Penicillium and Paecilomyces spp., was identified by morphology confirmed DNA sequence analysis. Susceptibility pattern showed high minimal inhibitory concentration voriconazole amphotericin B but low caspofungin, micafungin itraconazole.
Mycoplasma pneumoniae strains can be classified into two major genetic groups, P1 type 1 (P1-1) and 2 (P1-2). It remains unknown if clinical manifestations of lower respiratory tract infections (LRTI) in children differ between the genotypes. We aimed to determine M. genotype is associated with severity LRTI children. Medical charts 420 (≤15 years old) signs acute who were PCR positive for from pharyngeal swabs a recent epidemic analyzed. used culture pyrosequencing approach genotyping...
Cohort studies on physical fitness (PF) in former extremely preterm children are scarce and yield conflicting results. Therefore, this study aimed to assess the effect of birth PF school-age with a focus bronchopulmonary dysplasia (BPD).Eighty school-aged were enrolled longitudinal cohort study. Fifty born (<completed 28 weeks gestation): 19 had BPD, 31 did not; 30 term-born healthy included as controls. They monitored annually throughout primary school (ages 7-14 years) eight annual...
Cystic fibrosis (CF) is the most common autosomal recessive lethal hereditary disorder among whites. Survival of patients with CF has progressively improved over last four decades.As life expectancy been greatly extended, complications like osteopenia and CF-related diabetes mellitus (CFRDM) occur. In our article, a new management these two described.Gastrointestinal tract, exocrine pancreas liver are also affected in CF.Maintaining good nutrition while treating pancreatic insufficiency,...
Duchennova mišična distrofija (DMD) je najpogostejša in ena najresnejših mišičnih bolezni otroške dobe. Gre za na kromosom X vezano recesivno živčno-mišično bolezen, ki jo povzroča mutacija v genu distrofin. Primarno prizadene skeletne mišice srčno mišico.
 Pri večini dečkov se klinični znaki izrazijo z napredujočo mišično šibkostjo med 3. 5. letom starosti. Mišična šibkost bolj izražena proksimalnih kot distalnih mišicah začetni fazi vpliva poslabšanje funkcije spodnjih zgornjih udov....
<b>Background:</b> New therapeutics modalities in the last decades have increased survival rate of patients with severe forms congenital diaphragmatic hernia (CDH) resulting late morbidity. Surviving children remain at high risk developing long-term pulmonary consequences. There are limited data regarding lung function (LF) CDH survivors school age. <b>Aims and objectives:</b> to assess LF <b>Methods:</b> treated University Medical Centre Ljubljana from 2002 2010 were recruited study....
<b>Background:</b> Children with congenial heart defects (CHD) are prone to suffer from various respiratory conditions. Airway diseases can be associated developmental abnormalities or issue surgical complications. Flexible bronchoscopy (FB) offers effective diagnostic and treatment options in these patients. <b>Objective:</b> To evaluate the prevalence characteristics of airway CHD children. <b>Methods:</b> Medical records review study patients treated for at University children's hospital...
<b>Background:</b> Mycoplasma pneumoniae (MP) can be categorised into two genotypes, P1 type 1 (MP1) and 2 (MP2), based on the DNA sequence of adhesion protein. It remains unknown if clinical manifestations lower respiratory tract infections (LRTI) in children differ between genotypes. <b>Objectives:</b> To determine MP genotype is associated with severity LRTI children. <b>Methods:</b> Medical charts (≤ 15 years-old) signs who tested positive for by PCR from pharyngeal swabs 2014 were...
Akutni bronhiolitis je najpogostejša okužba spodnjih dihal pri otrocih, mlajših od dveh let. Zdravljenje akutnega bronhiolitisa podporno. Poleg skrbi za primerno hidracijo dodatek kisika otrokom s hipoksemijo praktično edini način zdravljenja teh otrok. Vrednost, ki jo dobimo pulznim oksimetrom, le posredna meritev dejanske vrednosti v krvi in ne odrazi resnosti bolezni. Z dodatkom sicer povišamo zasičenost hemoglobina kisikom tako zmanjšamo hipoksemijo, zdravimo pa osnovnega vzroka njen...
<b>Introduction:</b> Cystic fibrosis transmembrane conductance regulator modulator therapies have shown unprecedented health improvements in persons with cystic (pwCF). Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) therapy has been reported to improve several clinical outcomes these patients. Only limited data is currently available on treatment related lung ultrasound (LUS) asessment. We aimed compare LUS chest imaging at initiation and 6 months of treatment. <b>Methods.</b> Twenty (10...
<b>Background:</b> Structured and appropriately timed approach to end-of-life care decision-making has become an important part of in children with terminal illnesses. Despite its importance, many families medical teams face these issues fare late. <b>Objective:</b> Our aim was retrospectively evaluate decisions (EOLCD) made who died a university hospital9s respiratory high dependency unit. <b>Methods:</b> Medical files 14-year period were analyzed for the relevant history EOLCD process....
<b>Background:</b> Recent epidemiological data associated enterovirus D68 (EV-D68) to severe respiratory tract infections (RTI) in children. <b>Aim:</b> To determine whether children afflicted by EV-D68 infection suffer a more disease course than peers infected with other enteroviruses (EV). <b>Methods:</b> Medical charts of hospitalised for RTI and who were PCR EV positive nasopharyngeal swabs the period from June October 2014 analysed. Clinical patients compared those types EV....
<b>Background:</b> In 2014 several outbreaks of enterovirus D68 (EV-D68) infection were reported worldwide. <b>Aim:</b> To assess the characteristics hospitalized patients during EV-D68 outbreak, from June to October 2014, at University Children9s Hospital Ljubljana, Slovenia. <b>Methods:</b> Data children who tested positive for by PCR nasopharyngeal swabs, cerebrospinal fluid or stool in aforementioned period analyzed. <b>Results:</b> Out 282 samples, a total 18 (6.4%) (median age 4.1 yrs,...
<b>Background:</b> Specific anatomy and physiological responses exposes children to considerable risks during attempts for tracheal intubation (TI). Flexible bronchoscopy (FB) has been shown be an effective asset difficult airway management. <b>Objective:</b> To evaluate the characteristics performance of FB assisted TI in with <b>Methods:</b> Retrospective medical file analysis cases 2010-16 a tertiary paediatric hospital. <b>Results:</b> 14 13 (median age 0.8, range 0.0-17.1, IQR 4.9 yrs,...