A5016635364- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- RNA Research and Splicing
- Immunodeficiency and Autoimmune Disorders
- Mosquito-borne diseases and control
- Peripheral Neuropathies and Disorders
Centers for Disease Control and Prevention
2020-2021
The University of Texas Medical Branch at Galveston
2021
Oak Ridge Associated Universities
2021
Oak Ridge Institute for Science and Education
2021
Battelle
2021
Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses has been reported. We evaluated cell lines commonly used to isolate diagnose related diseases for their susceptibility SARS-CoV-2. Although multiple kidney from monkeys were susceptible SARS-CoV-2, we found many types derived humans, dogs, minks, cats, mice, chicken not. analyzed MDCK cells, which are most surveillance study of influenza viruses, that they not The low expression level the...
Enterovirus D68 (EV-D68) has been implicated in outbreaks of severe respiratory illness and is associated with acute flaccid myelitis (AFM). EV-D68 often detected patient samples but also stool wastewater, suggesting the potential for both enteric routes transmission. Here, we used a panel isolates, including historical pre-2014 isolate multiple contemporary isolates from AFM outbreak years, to define dynamics viral replication host response infection primary human airway cells stem...
Arboviruses, including dengue virus (DENV), Zika (ZIKV), and chikungunya (CHIKV), pose a significant global health economic burden, with Aedes aegypti serving as their primary vector. Arbovirus infection in Ae. progresses sequentially through the midgut (MG), carcass (CA), salivary glands (SG), each tissue exhibiting distinct antiviral responses. Here, we investigate tissue-specific mechanisms, focusing on small interfering RNA (siRNA) pathway SGs. Our results reveal that SGs possess weaker...
ABSTRACT Enterovirus D68 (EV-D68) is associated with respiratory disease in children. Between 2014 and 2018, biennial EV-D68 outbreaks coincided peaks of a polio-like neurologic condition called acute flaccid myelitis (AFM). We hypothesized that specific mutations within the currently circulating B3 clade impacted neurovirulence. However, recovery these strains from infectious clones by published methods proved unsuccessful. Therefore, we tested different cell lines, reagents, conditions to...
Abstract Enterovirus D68 (EV-D68) has been implicated in outbreaks of severe respiratory illness and acute flaccid myelitis (AFM) is detected patient samples from stool wastewater, suggesting both enteric routes transmission. Here, we used a panel EV-D68 isolates, including historical isolate multiple contemporary isolates AFM outbreak years, to define the dynamics viral replication host response infection primary human airway cells stem cell-derived enteroids. We show that some recent have...
Abstract Coinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses is inevitable as the COVID-19 pandemic continues. This study aimed to evaluate cell lines commonly used in virus diagnosis isolation for their susceptibility SARS-CoV-2. While multiple kidney from monkeys were susceptible permissive SARS-CoV-2, many types derived human, dog, mink, cat, mouse, or chicken not. Analysis of MDCK cells, which are most surveillance influenza viruses,...
Abstract Background Enterovirus D68 (EV-D68) has been implicated in outbreaks of severe respiratory illness and associated with acute flaccid myelitis (AFM), a disease which causes paralysis previously healthy patients, mostly children. AFM peaked even numbered years, at least 2014–2018. While 2020 was expected to be peak year, few cases were seen, likely due non-specific social distancing measures SARS-CoV-2. EV-D68 is primarily described as pathogen, contrast ‘classic’ enteroviruses that...