A5079635913- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Blood groups and transfusion
- Nuclear Structure and Function
- Biochemical Analysis and Sensing Techniques
- Diabetes and associated disorders
- Malaria Research and Control
- Cardiac Valve Diseases and Treatments
- Pediatric health and respiratory diseases
- Protein Structure and Dynamics
- Cystic Fibrosis Research Advances
- Neurogenetic and Muscular Disorders Research
- Virus-based gene therapy research
- Chronic Lymphocytic Leukemia Research
- Infective Endocarditis Diagnosis and Management
- Dietary Effects on Health
- Enzyme Structure and Function
- Amino Acid Enzymes and Metabolism
- Nutrition and Health in Aging
- vaccines and immunoinformatics approaches
- Diet and metabolism studies
- Immune Response and Inflammation
University of Alabama at Birmingham
2024
University of South Florida
2019-2023
National Institutes of Health
2015-2022
National Institute of Allergy and Infectious Diseases
2022
National Institute of Diabetes and Digestive and Kidney Diseases
2015-2021
University of South Florida St. Petersburg
2018-2019
University of Richmond
2012
Lipodystrophy syndromes are rare disorders of deficient adipose tissue. Metreleptin, a human analog leptin, improved metabolic abnormalities in mixed cohorts children and adults with lipodystrophy low leptin. Determine effects metreleptin on diabetes, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), growth, puberty pediatric patients Prospective, single-arm, open-label studies continuous enrollment since 2000. National Institutes Health, Bethesda, Maryland. Fifty-three aged 6 months...
Background Primary immunodeficiency is common among patients with autoimmune cytopenia. Objective The purpose of this study to retrospectively identify key clinical features and biomarkers primary (PID) in pediatric cytopenias (AIC) so as facilitate early diagnosis targeted therapy. Methods Electronic medical records at a tertiary care center were reviewed. We selected 154 both AIC PID (n=17), or alone (n=137) for inclusion two cohorts. Immunoglobulin levels, vaccine titers, lymphocyte...
Abstract Context Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency decreases expenditure (EE), which corrected following replacement. humans, data are mixed regarding leptin-mediated effects on EE. Objective To determine the of metreleptin EE in patients with lipodystrophy. Design, setting, and Nonrandomized crossover study 25 lipodystrophy (National Institutes Health, 2013-2018). Intervention The initiation cohort consisted 17 without prior exposure to...
In the era of newborn screening (NBS) for severe combined immunodeficiency (SCID) and possibility gene therapy, it is important to link SCID phenotype underlying genetic disease. western countries, X-linked IL-2 receptor gamma chain (IL2RG) adenosine deaminase (ADA) deficient are most common types can be treated by therapy. As a challenge, both IL2RG ADA genes highly polymorphic gene–based diagnosis may difficult if variant unknown significance or located in non-coding areas that not...
Type 2 diabetes (T2D) affects ∼10% of the US population, a subset whom have severe insulin resistance (SIR) (>200 units/d). Treatment these patients with high-dose presents logistical and compliance challenges. We hypothesized that mild caloric restriction would reduce requirements in T2D SIR. This was retrospective study at National Institutes Health Clinical Center. Inclusion criteria were as follows: T2D, dose >200 units/d or >2 units/kg/d. The intervention consisted during 3 to 6-day...
Proteins can take on an array of conformations determined by regional flexibility the protein. This may play critical roles in catalysis and allosteric regulation. The relationship between structure function was studied to determine contributions particular amino acids 3phospho‐glycerate dehydrogenase. (3pGDH), protein's function. Based upon available crystal structures a number were identified analysis temperature factors that show altered response serine binding. In addition conjunction...
Welcome to Annals of Global Health,Annals Health is a peer-reviewed, fully open access, online journal dedicated publishing high quality articles all aspects global health. The journal's mission advance health, promote research, and foster the prevention treatment disease worldwide. Its goals are improve health well-being people, equity, wise stewardship earth's environment. latest impact factor 3.64.Annals supported by Program for Public Common Good at Boston College. It was founded in 1934...
Abstract Leptin is an adipokine that reflects energy storage levels. Patients with obesity have high leptin, hypertension, and increased cardiovascular disease (CVD) risk. In rodents, leptin increases blood pressure (BP), by increasing sympathetic nervous system (SNS) activity, suggesting may cause hypertension CVD. Studies of administration in 2 human models deficiency (weight reduced congenital deficiency) showed decreased SNS activity the leptin-deficient state, which after replacement....
Abstract Background An estimated 241 million malaria cases and 627,000 deaths occurred worldwide in 2020. Efforts to develop a higher efficacy vaccine are global priority, but parasites pose complex biological puzzle for development. Innovative strategies include transmission blocking vaccines (TBV) that target the mosquito stages of parasite development interrupt transmission. The current leading TBV called Pfs230D1-EPA targets Pfs230, Plasmodium falciparum gamete surface protein mediates...
Abstract Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency associated with decreased body temperature and expenditure (EE), which reversed replacement. Leptin’s role in EE humans unclear; however, one study of 10% weight-reduced healthy subjects suggested replacement to pre-weight loss levels restored the decline EE, thyroid hormone, catecholamines weight loss. Patients lipodystrophy (LD) are characterized by adipose tissue can serve as models effects...