A5037347309- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Acute Lymphoblastic Leukemia research
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Neonatal Respiratory Health Research
- Genomics, phytochemicals, and oxidative stress
- Folate and B Vitamins Research
- Urological Disorders and Treatments
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- Asthma and respiratory diseases
- Ion channel regulation and function
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Congenital Ear and Nasal Anomalies
- Synthesis of Tetrazole Derivatives
- Melanoma and MAPK Pathways
- Quinazolinone synthesis and applications
- Oral and gingival health research
- Connexins and lens biology
- Retinoids in leukemia and cellular processes
Baylor College of Medicine
2019-2025
Texas Children's Hospital
2019-2025
Texas A&M University
2013-2019
University of Iowa
2018
Background Folate and cobalamin are essential cofactors for homocysteine ( HCY ) metabolism. Hyperhomocysteinemia, a multifactorial condition, may reflect B vitamin deficiency is associated with increased risk of cardiovascular disease, thrombosis, neurodegenerative chronic gastrointestinal diseases in humans. Hyperhomocysteinemia has been reported Greyhounds suspected enteropathy. Objectives To evaluate the frequencies association between hypofolatemia hyperhomocysteinemia Greyhounds....
Fecal canine alpha 1 -proteinase inhibitor (cα -PI) concentration has been reported to be increased in dogs with protein-losing enteropathy due the loss of cα -PI into gastrointestinal tract. A chronic may theoretically deplete serum -PI, potentially altering proteinase-to-proteinase balance. Protein-losing occur frequently certain dog breeds such as Yorkshire Terriers and associated hypocobalaminemia. The objective was compare concentrations without cobalamin (COB) deficiency. Serum samples...
Abstract Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow with 5-year overall survival less than 10% in patients over age 65. Limited progress has been made patient outcome because inability to selectively eradicate leukemic stem cells (LSC) driving refractory and relapsed disease. Herein, we investigated role reprogramming factor KLF4 AML its critical self-renewal stemness embryonic cancer cells. Using a conditional Cre-lox Klf4 deletion system MLL-AF9 retroviral...
// Andrew Henry Lewis 1 , Cory Seth Bridges Viraaj Singh Punia Abraham Fausto Jornada Cooper 2 Monica Puppi and H. Daniel Lacorazza Department of Pathology & Immunology, Baylor College Medicine, Texas Children's Hospital, Houston, TX 77030, USA SMART Program at Medicine Correspondence to: Lacorazza, email: hdl@bcm.edu Keywords: acute myeloid leukemia; KLF4; cancer; gene editing; cell growth Received: November 20, 2020 Accepted: January 19, 2021 Published: February 16, Copyright: © et al....
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric with a worse prognosis than most frequent B-cell ALL due to high incidence of treatment failures and relapse. Our previous work showed that loss the pioneer factor KLF4 in NOTCH1-induced T-ALL mouse model accelerated development through expansion leukemia-initiating cells activation MAP2K7 pathway. Similarly, epigenetic silencing gene children was associated activation. Here, we small molecule 5Z-7-oxozeaenol (5Z7O)...
Novel drugs are needed to increase treatment response in children with high-risk T-cell acute lymphoblastic leukemia (T-ALL). Following up on our previous report the activation of MAP2K7-JNK pathway pediatric T-ALL, here we demonstrate that OTSSP167, recently shown inhibit MAP2K7, has antileukemic capacity T-ALL. OTSSP167 exhibited dose-dependent cytotoxicity against a panel T-ALL cell lines IC50 nanomolar range (10-50 nM). induces apoptosis and cycle arrest lines, associated at least...
Measurement of serum trypsin-like immunoreactivity (TLI) is used to assess exocrine pancreatic function in dogs and cats. Ferrets ( Mustela putorius furo) serve as valuable animal models for human diseases such cystic fibrosis other pulmonary diseases, may be a useful model including pancreatitis. We developed analytically validated competitive radioimmunoassay (RIA) measurement TLI ferret by determination analytical sensitivity, assay linearity, accuracy spiking recovery, precision,...
Abstract Background Measuring S100A12 concentrations in serum and feces is a sensitive specific marker of inflammation, such as seen with chronic gastrointestinal inflammation people dogs. Biomarkers cats are currently lacking. Objectives We aimed to analytically cross‐validate the canine S100A12‐ELISA for measurement feline specimens. Methods The ELISA was validated by assessing dilutional linearity, spiking/recovery, intra‐ inter‐assay variability. Reference intervals fecal were calculated...
The mitogen-activated protein kinase signaling cascade is conserved across eukaryotes, where it plays a critical role in the regulation of activities including proliferation, differentiation, and stress responses. This pathway propagates external stimuli through series phosphorylation events, which allows signals to influence metabolic transcriptional activities. Within cascade, MEK, or MAP2K, enzymes occupy molecular crossroads immediately upstream significant signal divergence cross-talk....
The mitogen-activated protein kinase signaling cascade is conserved across eukaryotes from yeast to humans, where it plays a central role regulating activities including proliferation, differentiation, and stress responses. This pathway propagates external stimuli through series of phosphorylation events, allowing signals influence metabolic transcriptional activities. Within the cascade, MEK, or MAP2K, enzymes occupy molecular crossroads situated immediately upstream significant signal...