A5038261387- Genetic Neurodegenerative Diseases
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Wheat and Barley Genetics and Pathology
- Agriculture and Biological Studies
- Protein Tyrosine Phosphatases
- Genetic Associations and Epidemiology
- Molecular Biology Techniques and Applications
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Cardiomyopathy and Myosin Studies
- Eosinophilic Disorders and Syndromes
- Forensic and Genetic Research
- Agricultural Productivity and Crop Improvement
- Advanced biosensing and bioanalysis techniques
University at Albany, State University of New York
2021-2024
Albany State University
2021-2024
Azerbaijan National Academy of Sciences
2021
Spinocerebellar ataxias (SCAs) are a genetically heterogenous group of devastating neurodegenerative conditions for which clinical care currently focuses on managing symptoms. Across these diseases there is an unmet need therapies that address underlying disease mechanisms. We utilised the shared CAG repeat expansion mutation causative large subgroup SCAs, to develop novel disease-gene independent and mechanism agnostic small molecule screening approach identify compounds with therapeutic...
Abstract The spinocerebellar ataxias (SCAs) are a group of dominantly inherited neurodegenerative diseases, several which caused by CAG expansion mutations (SCAs 1, 2, 3, 6, 7 and 12) more broadly belong to the large family over 40 microsatellite diseases. While dysregulation alternative splicing is well defined driver disease pathogenesis across contribution in SCAs poorly understood. Furthermore, despite extensive studies on differential gene expression, there remains gap our understanding...
Abstract The spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of rare dominantly inherited neurodegenerative diseases characterized by progressive ataxia. most common mutation seen across the SCAs is CAG repeat expansion, causative for SCA1, 2, 3, 6, 7, 12 and 17. We recently identified dysregulation alternative splicing as novel, presymptomatic transcriptomic hallmark in mouse models 1, 3 7. In order to understand if feature patient-derived cell SCAs, we performed RNA...
Abstract The emergence of a highly contagious novel coronavirus in 2019 led to an unprecedented need for large scale diagnostic testing. associated challenges including reagent shortages, cost, deployment delays, and turnaround time have all highlighted the alternative suite low-cost tests. Here, we demonstrate test SARS-CoV-2 RNA that provides direct detection viral eliminates costly enzymes. We employ DNA nanoswitches respond segments by change shape is readable gel electrophoresis. A new...
This paper gives an overview of the collection history for species from Triticeae Dum.tribe in Karabakh region Azerbaijan up to date its occupation.By covering most Lesser Caucasus with semi-desert and dry steppe climate, has favorable conditions grass diversity.There are 14 genera tribe Azerbaijan, which historically 10 also were found region.The data this article have been presented as a summary information recorded different literature sources, that would be useful planned monitoring...